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Articles by J. Jones
Total Records ( 6 ) for J. Jones
  P. E Johnson , S. M Rickert and J. Jones

Objective  To determine whether a 3-day course of postoperative antibiotics is as effective as a 7-day course in reducing pain and reducing time to resumption of a normal diet and level of activity following pediatric tonsillectomy.

Design  A prospective, randomized, placebo-controlled trial.

Setting  Academic medical center.

Patients  Forty-nine patients were enrolled in the study. Preoperative demographic information was obtained.

Interventions  Tonsillectomy with or without adenoidectomy was performed by the senior author (J.J.) using electrocautery. Patients were randomized to receive either a 3- or 7-day course of amoxicillin.

Main Outcome Measures  Parents were asked to record the following information: analgesic use for the first 7 postoperative days, postoperative days the child initiated his or her usual diet and level of activity, and medical treatment for oral hemorrhage or dehydration.

Results  Of the 49 patients, 26 were randomized to receive 7 days of postoperative antibiotics (group A) and 23 to receive 3 days of antibiotics, followed by 4 days of placebo (group B). Results were obtained for 47 of the enrolled patients (96%). No statistically significant difference was noted between the 2 groups with regard to postoperative pain or time to resumption of a normal diet and level of activity.

Conclusion  A 3-day course of antibiotics following pediatric tonsillectomy is as effective as a 7-day course with regard to postoperative analgesic use and resumption of normal diet and level of activity.

Trial Registration Identifier: NCT00662987

  D.S. Williams , M. Verghese , L.T. Walker , J. Boateng , L.A. Shackelford , M. Guyton , J. Jones , J. Khatiwada and C.B. Chawan
  This study was designed to evaluate the anticarcinogenic effect of Flax Seed Meal (FSM) (10 and 20%) and Flax Seed Oil (FSO) (7 and 14%) on Azoxymethane (AOM)-induced colon tumors in Fisher 344 male rats during initiation (I), promotion (P) and Initiation + Promotion (I+P) stages of carcinogenesis. After an acclimatization period of 1 week, 14 groups of Fisher 344 male weanling rats, 3-4 week old (15 per group) were assigned to 2 control groups fed AIN 93G diet and AIN 93G + 14% soybean oil (SBO) (high fat control). The remaining 12 groups were assigned to 10 and 20% FSM (I, P and I+P) and 7 and 14% FSO (I, P and I+P). All rats received 16 mg kg-1 body weight of AOM at 7 and 8 week of age. At 20 weeks of age all animals were switched to AIN-93 M diets and at 45 week of age all rats were killed by CO2 asphyxiation. Tumor incidence (%) in colon of rats fed C (7 and 14%) was both 100. Tumor incidences for rats fed FSO (7 and 14%) at I, P and I+P were: 100, 100, 61, 60, 58 and 61, respectively and 80, 80, 66.6, 66.6, 66.6 and 31, respectively for rats fed FSM (10 and 20%) at I, P and I+P. Tumors per tumor-bearing ratios for groups fed C; 10 and 20% FSM (I, P and I + P) were 3.86, 1.28, 1.70, 1.75 and 1.0, 0.94, 0.64, respectively. In rats fed C (7 and 14%) and 7 and 14% FSO (I, P and I + P) T/TBR ratios were 3.86, 5.96; 1.4, 0.6, 0.6; 1.90, 0.8, 0.8, respectively. Glutathione-S-Transferase activity (a phase II detoxification enzyme) was significantly (p<0.05) higher in rats fed 10 and 20% FSM and 7 and 14% FSO compared to controls. The results of this study indicate that bioactive phytochemicals such as dietary fiber and lignans such as secoisolariciresinol diglycoside (SDG) found in flax seed meal and essential fatty acids such as α-linolenic acid (ALA) found in flax seed oil suppress colon tumors, particularly at the promotion stage and flax seed products may therefore be effective chemopreventive agents.
  M. Guyton , M. Verghese , L. T. Walker , C. B. Chawan , L. Shackelford , J. Jones and J. Khatiwada
  The aim of this study was to explicate the effect of feeding peanuts at 3 levels (10, 15 and 20 g 100-1 g of feed) on azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF) in Fisher 344 male rats. Four groups of rats were fed AIN93-G control diet (n = 8) and 3 experimental diets containing 10, 15 and 20% peanuts (n = 8) for 13 weeks. All rats received 16 mg kg-1 body weight of AOM at 7 and 8 week of age. The rats continued to receive the assigned diets until euthanized by CO2 at 17 weeks of age. The percent reductions in ACF in the groups consuming diets containing 10, 15 and 20% peanuts were 31.9, 48.7 and 61%, respectively. GST activity (μmol mg-1) in the rats fed control diet was significantly (p<0.05) lower compared to the rats fed peanuts. Present results indicate that feeding peanuts significantly reduced AOM-induced ACF in Fisher 344 male rats. The phytochemicals present in peanuts may have antitumor properties and could possibly reduce colon cancer.
  J. Jones , M. Verghese , L.T. Walker , L. Shackelford and C.B. Chawan
  Inhibitory potential of grape products on Azoxymethane (AOM) induced Aberrant Crypt Foci (ACF) were investigated in Fisher 344 male rats. Bioactive components present in the grapes have shown anticarcinogenic properties in in vitro and epidemiological studies. Following an acclimatization period of one week, 24 male weanling rats were fed control and experimental diets consisted of either grape Juice (50%) or Raisins (10%). All rats received 16 mg kg-1 b.wt. of AOM at 7 and 8 week of age. Rats were euthanized by CO2 at 17 week of age. Number of ACF was enumerated in colon and Glutathione S-transferase (GST) activity was analyzed in liver of rats. No significant differences were observed in the weight gain of rats among the groups. Highest (73%) reduction in ACF was found in rats fed with Grape juice followed by rats fed with raisins (66%). The total number of crypts were significantly lower in treatment group rats (Juice-93.62±4.3; raisins-116.66±5.3) compared to the control group (358±13.3). Glutathione S-transferase enzyme activity was increased by 2-3 fold in the treatment groups. This study indicates that administering grape juice at 50% and raisins at 10% in diet of rats significantly reduced the ACF in Fisher 344 male rats and may offer protection against colon cancer development.
  G Sandhu , P Casares , A Farias , A Ranade and J. Jones

Pulmonary renal syndrome (PRS) is a combination of diffuse pulmonary haemorrhage and glomerulonephritis (GN). Though an established form of presentation in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated GN and vasculitis, diffuse pulmonary haemorrhage is extremely unusual in those with ANCA-negative GN. We present here a case of a 76-year-old Hispanic female with stage IV chronic kidney disease (serum creatinine of 2 mg/dL), who presented with diffuse alveolar haemorrhage and nephritic syndrome. Less than 1 week prior to the full-blown PRS, she was treated for an apparent pneumonia as was evidenced by a right lower lobe infiltrate on her chest X-ray. Retrospectively, this was likely a focal pulmonary haemorrhage. ANCA were persistently negative, and the remainder of her immunologic workup was normal. Renal biopsy was diagnostic of crescentic pauci-immune GN. The patient required a ventilator and haemodialysis support (serum creatinine 6 mg/dL), and was successfully treated with methylprednisolone, cyclophosphamide and a total of six cycles of plasmapheresis. Once her oliguria resolved, the creatinine plateaued at 2.7 mg/dL. Our case illustrates that diffuse alveolar haemorrhage can be a distinct clinical feature even in patients with ANCA-negative pauci-immune crescentic glomerulonephritis.

  R. Khakvar , K. Sijam , M.Y. Wong , S. Radu , J. Jones and K.L. Thong
  Pulse-Field Gel Electrophoresis (PFGE) and BOX-PCR patterns were used to determine the phylogenetic relationships among 32 strains of Ralstonia solanacearum collected from banana farms in West Malaysia. Eighty two percent (25 stains) were biovar 3 and the remainders were biovar 4. Cluster analysis based on PFGE and BOX-PCR fingerprinting showed that there was significant genetic variation among all strains within this species in West Malaysia. Patterns of DNA fingerprinting in both methods were significantly correlated with sampling sites and revealed the regional similarity among the strains. The PFGE patterns varied from 78 to 99% while BOX-PCR patterns showed a high degree of variation among R. solanacearum strains. Genomic fingerprinting by PFGE also revealed one that was significantly correlated to biovar type while BOX-PCR pattern analysis was unable to differentiate various biovars. This study clearly showed that R. solanacearum strains were phylogenetically similar within a region but diverse between regions despite biovar designation.
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