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Articles by J. F Angle
Total Records ( 1 ) for J. F Angle
  W Shi , Z Zhang , M. H Chen , J. F Angle and A. H. Matsumoto

C3H/HeJ (C3H) mice develop much smaller atherosclerotic lesions than C57BL/6 (B6) mice when deficient in apolipoprotein E (apoE–/–) or fed an atherogenic diet. The 2 strains differ in H2 haplotypes, with B6 having H2b and C3H having H2k. C3.SW-H2b/SnJ (C3.SW) is a congenic strain of C3H/HeJ in which H2k is replaced with H2b.

Methods and Results—

We performed bone marrow transplantation and found that atherosclerosis-resistant C3.SW.apoE–/– mice reconstituted with bone marrow from either C3.SW.apoE–/– or B6.apoE–/– mice after lethal irradiation had significantly larger atherosclerotic lesions than B6.apoE–/– mice receiving identical treatments and much larger lesions than C3H.apoE–/– mice reconstituted with syngeneic bone marrow. For syngeneic transplantation, C3.SW.apoE–/– mice exhibited a 21-fold increase in lesion size over C3H.apoE–/– mice (152 800±21 937 versus 7060±2290 µm2/section) and a near 4-fold increase over B6.apoE–/– mice (40 529±4675 µm2/section). C3.SW.apoE–/– mice reconstituted with syngeneic marrow exhibited enhanced lesion formation relative to those reconstituted with B6 marrow (152 800±21 937 versus 107 000±9374 µm2/section; P=0.067). Sublethal irradiation led to a 6-fold increase of lesion size in C3.SW.apoE–/– mice (9795±2804 versus 1550±607 µm2/section; P=0.008). Wild-type C3.SW mice reconstituted with apoE+/+ or apoE–/– bone marrow had significantly larger atherosclerotic lesions than C3H mice receiving identical treatments on an atherogenic diet.


These results indicate that gene(s) within the H2 region have a dramatic impact on radiation-enhanced atherosclerosis, and their effect is conveyed partially through bone marrow–derived cells.

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