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Articles by Idris Abdullahi Nasir
Total Records ( 4 ) for Idris Abdullahi Nasir
  Idris Abdullahi Nasir , Adekola Hafeez Aderinsayo , Hadiza Umar Mele and Maryam Muhammad Aliyu
  Toxoplasma gondii (T. gondii) is one of the few known zoonotic parasites that have the ability to induce miscarriage and congenital transmission. This study sought to determine and update the prevalence of anti-toxoplasma IgM and IgG antibodies in pregnant women and their associated risks at the University of Maiduguri Teaching Hospital, Maiduguri, Nigeria. Blood samples from 360 pregnant women aged 19-42 years were analyzed for anti-toxoplasma IgM, IgG antibodies and IgG avidity using Euroimmun® ELISA kits. Structured questionnaires were used to obtain participants’ sociodemographic data. Out of the 360 pregnant women studied, 32 (8.9%) and 144 (40.0%) were seropositive for T. gondii specific IgM and IgG antibodies, respectively. Of those with IgM seropositivity, 26 (7.2%) had primary infection (i.e., IgM+IgG-low IgG avidity) while 6 (1.7%) had reactivated infection (IgG+IgM+high IgG avidity). The IgM seropositivity was statistically significant among women who kept cat pets than those that don’t (75 vs. 25%, p = 0.025). The IgG seropositivity rate was significantly higher among pregnant women from urban than those from rural residential areas (48.4 vs. 19.2%, p = 0.001). Likewise employed women were more likely to contract primary toxoplasmosis than the unemployed (82.2 vs. 31.6%, p = 0.0025). Serological evidence of primary toxoplasmosis was significantly high among pregnant women studied while a significant proportion of other women were at risk of contracting primary toxoplasmosis. Screening for toxoplasmosis during antenatal care should be encouraged in order to detect infected women so that appropriate clinical modalities can be instituted.
  Idris Abdullahi Nasir , Yahaya Usman and Adamu Babayo
  Cytomegalovirus (CMV) screening in pregnancy has not been recommended during antenatal clinic days in Nigeria and most countries of the world. However, CMV has been widely accepted as, the viral etiology with the greatest propensity for congenital transmission. Due to CMV ubiquity, seronegative women are highly susceptible to CMV infection and thus, has increased risk of maternal infections and possibly congenital transmission. In view of this, this study aimed to determine the seroprevalence of women, who are anti-CMV IgG seronegative, thus susceptible to CMV infections. We made use of NovalisaTM anti-CMV IgG ELISA kit to screen 182 blood samples of pregnant women attending antenatal clinics of University of Maiduguri Teaching Hospital (UMTH), Maiduguri, Nigeria. Structured questionnaire was used to collect participants’ sociodemographic data. A total of 38 out of 182 subjects were anti-CMV IgG seronegative making a seroprevalence of 20.9%. There was significant statistical association between seronegativity and subjects’ education level and history of previous blood transfusion (p<0.05) but not with age, parity, gravida and gestation age (p>0.05). Findings from our evaluation indicated that many pregnant women were anti-CMV IgG seronegative and thus susceptible to maternal CMV infections. These women have high risk of contacting primary CMV infections and might eventually pose danger to their unborn fetuses in the absence of appropriate preventive measures.
  Idris Abdullahi Nasir , Adamu Babyo , Anthony Uchenna Emeribe and Noel Ochada Sani
  There is no doubt that antibiotics have saved the human race from a lot of suffering due to bacterial disease burden. Without these drugs, millions of people would have succumbed to infectious diseases. Regrettably, antibiotic resistance (ABR) threatens the effective treatment of these pathogens. The incidence of ABR and the emergence of multidrug-resistance bacteria are on the increase and has been considered a major public health issue. In view of this, we conducted this review of relevant published articles using extensive literature search made through PubMed, Google scholar, Scopus and HINARI on the emergence and spread of ABR, challenges and possible solutions to ABR surveillance especially in Nigeria. Findings from our review revealed that surveillance for ABR in pulmonary tuberculosis was the only system in good function in Nigeria. Regrettably, most hospitals have poor ABR systems for other bacteria. This setback was found to be linked to multifactorial reasons. Urgent and coordinated action is required at all levels to ensure preservation of these life-saving drugs for future utility. Detection of resistance and monitoring its spread requires appropriate laboratory-based surveillance. In addition, there is need to sustain the efficiency of diagnostic laboratories, improved surveillance, better regulation and education of the public, clinicians/prescribers in the appropriate use of antibiotics.
  Amos Dangana , Idris Abdullahi Nasir , Joy Adaramala , Andrew Nuhu and Bivan Murna
  The ultimate goal of blood transfusion service is to provide qualitative, safe and adequate blood and blood products to recipients. Transfusion of hyperbilirubinated blood may be detrimental in clinical practice during exchange blood transfusion. This is particularly implicative when blood with poor morphological and biochemical constitutes are transfused to neonates and critically ill patients. To determine the incidence and possible implications of hyperbilirubinaemia among blood donors in Benin City, Nigeria, blood samples were collected from 100 Transfusion-Transmissible Infections (TTI) seronegative commercial donors and 20 TTI voluntary donors. These blood samples were analyzed for serum bilirubin (unconjugated and total) concentrations, Packed Cell Volume (PCV) and hemoglobin concentration using the Evelyn’s, Mally’s, microhaematocrit and cyanometheamoglobin methods, respectively. Out of the 120 blood donors, 8 (6.67%) of the commercial donors had a total bilirubin greater than 1 mg dL–1 (hyperbilirubinaemic) while none of the voluntary donors had total bilirubin values >1 mg dL–1. The Mean SEM serum unconjugated bilirubin, total bilirubin, PCV and hemoglobin of the commercial donors were 0.35±0.02 and 0.50±0.03 mg dL–1, 36.4±0.45% and 11.5±2.38 g L–1, respectively while the levels in control subjects were 0.05±0.01 and 0.09±0.02 mg dL–1, 44±0.64% and 13.2±2.54. Serum bilirubin was significantly higher (p = 0.00062) while the PCV and hemoglobin concentration were lower (p = 0.00145 and p = 0.00125, respectively) in commercial blood donors when compared with voluntary blood donors. Based on our findings, screening of blood for bilirubin level before transfusion is not needful, however serum bilirubin screening of blood to be transfused to neonates and critically ill patients should be considered.
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