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Articles by I.H. Kilic
Total Records ( 5 ) for I.H. Kilic
  M. Bitiren , D. Musa , A. Ozgonul , M. Ozaslan , A. Kocyigit , O. Sogut , Muhammet E. Guldur , I.H. Kilic , Ali Z. Karakilcik and M. Zerin
  The present study was planned to investigate the protective effects of herbal methanol extracts of Hypericum perforatum (HP) and Urtica dioica (UD) and herbal agueous extract of Camelia sinensis (CS)-containing antioxidants on carbon tetrachloride (CCl4)-induced hepatic injury and lymphocyte DNA damage. Adult male albino rats (n 50) were separated into five groups of ten each, as follows: control group; CCl4 group; CCl4+HP extract group; CCl4+UD extract group; CCl4+CS extract group. All extract groups were fed with 200 mg kg-1 extracts of HP, CS and UD, respectively once every alternate day for 7 weeks. CCl4 injections were applied to the CCl4 and extract groups at the dose of 0.4 mL kg-1. Malondialdehyde, total oxidant status and total antioxidative capacity levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl4 group and indicated increased oxidative stress. The DNA damages detected via commet assay were significantly higher than in the CCl4 group. Treatment by extracts of HP, CS or UD were significantly decreased this oxidative stress and ameliorated lymphocyte DNA damage. These results indicate that the herbal extracts of HP, UC and CS have beneficial effects on liver and lymphocyte DNA damage induced by CCl4 probably due to their antioxidant properties.
  M. Ozaslan , I.D. Karagoz , R.A. Lawal , I.H. Kilic , A. Cakir , O.S. Odesanmi , I. Guler and O.A.T. Ebuehi
  Background: Tetrapleura tetraptera fruit is widely used in Southern Nigeria for a range of pharmacological actions. Methodology/Principal Findings: In this study, the cytotoxic and antiproliferative effects of the ethanolic extract of fruit were studied in vitro and in vivo by using ehrlich ascites carcinoma cells and tumor modelling, respectively. Cytotoxic activity was determined by incubating the ehrlich ascites carcinoma cells with 0.1, 1, 10 and 100 μg mL–1 of the extract. In vivo study, 20, 40 and 80 mg kg–1 b.wt., doses of the extract was inoculated by intraperitoneal administration to mice following to carcinoma cells inoculation by same way. The extract was cytotoxic to carcinoma cells as assessed by both in vitro and in vivo experiments. Conclusion/Significance: The IC50 of the extract was found to be 250 μg mL–1. Results showed that the Tetrapleura tetraptera increased the life span of mice via reducing the number of the viable EAC cells, decreasing in ascites fluid volume and tumor burden. The DNA fragmentation assay also showed that it has a possible pro-apoptotic effect.
  M.E Guldur , M. Ozaslan , T. Aytekin , I.H. Kilic and I.D. Afacan
  The ability of zinc to retard oxidants and to be antioxidant has been recognized for many years. In the present study, it is aimed to determine histological toxic effects of zinc supplementation on hepatic tissue. It was also planned to determine effect of zinc on TAL. In this study, 24 male Wistar albino rats were used. All animals were divided 4 groups; 1 control, 3 experimental group. Three milliliter (227 mg L-1 day-1) zinc-sulphate was treated in experimental groups during 15, 30 and 45 days, respectively. TAL, AST and ALT levels from collected cardiac blood samples (3 mL) were measured. For histological investigation, liver tissue was removed and stained with Haematoxilen-eosin. It was determined that, TAL reduced in group I which was given zinc during 15 days and TAL increased in group II and Group III which was given zinc 30 and 45 days, respectively compared to that of group control. Results of the histological investigation showed that no toxicity in even experimental groups.
  I.H. Kilic , M. Ozaslan , T. Karsligil , I.D. Karagoz and Y. Zer
  Pathogens causing summer diarrhea examined to detect among children less than 5 years of age in Gaziantep. We conducted among 100 children with diarrhea during summer at the pediatric hospital of Gaziantep. In stool samples from children, Rotavirus with Rotatect kit (Dade Behring, Germany), Entamoeba spp. with direct microscopy and bacterial pathogens with cultural techniques investigated. Cystic form of Entamoeba spp. was determined in 61 (61%) and Rotavirus antigen in 25 positive samples (25%). A predominant bacterium was determined in total 87 stool samples (87%). Despite of only cystic form of Entamoeba spp. was determined in seven, only bacteria in 22 and only Rotavirus in one; two of them were determined in 67 out of stool samples. According to comparison with stool samples belong to various months we have found that, Rotavirus and E. coli are the most pathogenic agents in August more than June and July.
  I.H. Kilic , M. Ozaslan , I.D. Karagoz , Y. Zer and V. Davutoglu
  Mobile phones are dispensable accessories in social life and normally they are not cleaned properly. Therefore, they serve as a reservoir of bacteria and may cause nosocomial infections in hospitals. The purpose of this study was to investigate microbiological colonization of mobile phones used by healthcare staffs. The study was carried out collecting swab samples with Cary-Blair transport medium from mobile phones of attending healthcare staffs from different departments of three hospitals in March, 2008. All collected samples were inoculated in 5% sheep blood agar, eosin-methylene blue agar and Sabouraud Dextrose agar. Isolated bacteria were identified using by classic technique and Vitec2 (Biomerieux, France) full automated bacteria identification system. Growth was observed in 65 of collected 106 samples, corresponding to 61.3%. The most frequent bacteria were Staphylococcus epidermidis followed by Staphylococcus aureus, Bacillus sp., Corynebacterium sp. and Escherichia coli, respectively. In conclusion, bacteria were colonized on mobile phones frequently and mobile phones may become reservoir of microorganism for nosocomial infections.
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