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Methanol extract of the root of Cochlospermum tinctorium
was evaluated for antibacterial activities using hole-in-plate bioassay
technique against Escherichia coli, Staphylococcus aureus,
Klebsiella pneumoniae, Corynbacterium ulcerans, Proteus
mirabilis and Shigella dysentriae using ciprofloxacin (10 μg
mL-1) and gentamicin (10 μg mL-1) as reference
standards. The extract was active on all the test organisms at concentration
of 2000 μg mL-1. The activity of the extract against S.
dysentriae was found to be more potent with MIC 100 and MBC 500 μg
mL-1. Time kill studies showed that the antibacterial activities
were time dependent. Phytochemical screening revealed the presence of
alkaloids, flavonoids, tannins and cardiac glycosides. These phytochemicals
could be responsible for the antimicrobial activities exhibited by the
extract and hence justify the ethnomedicinal uses of C. tinctorium.
