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Articles by I. Sarathchandiran
Total Records ( 2 ) for I. Sarathchandiran
  I. Sarathchandiran , R. Manavalan , M.A. Akbarsha , B. Kadalmani and P.K. Karar
  Ethanol extract of Capparis aphylla was evaluated for possible spermatotoxic effect in 90 days old male rat. The ethanol extract at the doses of 50, 100 and 200 mg kgG1 of body weight was administered intra peritonially for 55 days. The analysis consists of counts, motility and abnormalities of the cauda epididymal sperm adapting light microscopy. The fertility of the treated rats was reduced drastically. The sperm concentration in the epididymis and sperm motility decreased, whereas sperm abnormalities increased in particular sperm abnormalities like flexed head, detached head and coiling of end tail. In extract treated rat the duration of sperm motility reduced with respect to the increased dose level. The results indicate disruption of the spermatogenic as well as androgenic compartment of the testis by the ethanolic extract of C. aphylla. The results also reflect an alteration of epididymal function towards the post-testicular sperm maturation processes by C. aphylla.
  I. Sarathchandiran , R. Manavalan , M.A. Akbarsha , B. Kadalmani and P.K. Karar
  Ethanol extract of Capparis aphylla (Roth.) whole plant (EECA) was evaluated for possible testicular antisteroidogenic activity in mature male rat. The ethanol extract at the doses of 50, 100 and 200 mg kgG1 body weight (i.p) arrested the testicular steroidogenisis. The cholesterol and ascorbic acid content in testis were significantly elevated in treated rat. The extract also significantly inhibited the activity of Δ5-3β-hydroxy steroid dehydrogenase (Δ5-3β-HSD) and glucose-6-phosphate dehydrogenase (G-6-PD), the two key enzymes involved in testicular steroidogenesis. Results of this study suggested that the ethanol extract of whole plant of Capparis aphylla (Roth.) acts as an testicular antisteroidogenic agent.
 
 
 
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