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Articles by I. Onyesom
Total Records ( 2 ) for I. Onyesom
  I. Onyesom and E.O. Anosike
  This research was conducted to monitor the changes in the serum levels of some traditional markers of liver function during ethanol experimental toxicity in rabbits. The test rabbits were orally given 1.5 g (40%) ethanol/kg body weight as single daily dose for a continuous period of fifteen weeks. Results show that the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) significantly increased by 42.6 and 28.8% (p<0.05) at the 10th week of ethanol administration. However, the AST and ALT activity values, reduced to 30.9 and 15.9% (p>0.05) at the 15th week when the fatty hepatitis became recognized, as evidenced by the elevated degree of unconjugated bilirubin (p<0.05) and the microscopic examination, which indicates fibrotic changes in hepatic sections of the ethanol-treated rabbits. The conjugated:unconjugated (C:U) bilirubin ratio vs the AST:ALT ratio at the 5th, 10th and 15th week of ethanol treatment were 0.97 vs 0.66, 0.73 vs 0.65 and 0.56 vs 0.66. Those of the control rabbits were 1.87 vs 0.59, 1.68 vs 0.59 and 1.43 vs 0.61. The basal (0 week) C:U and AST: ALT ratios were 1.95 and 0.59, respectively. These characteristic ratios and the peculiar changes in AST and ALT activity values could be beneficial in predicting the stage and degree of hepatic damage.
  I. Onyesom , U.E. Uzuegbu , E.K. Nwangwa , G.E. Umukoro and I.R. Aninyei
  Alcohol metabolism has been reported to generate Reactive Oxygen Species (ROS) which initiate series of oxidative reactions that culminate in hyperuricemia and accompanying cardiovascular dysfunction. Present study investigates the effect of a free radical scavenger-vitamin E, on alcohol-induced increase in serum uric acid, triacylglycerol and blood pressure. One hundred consenting undergraduates (60 males and 40 females) in apparent good health and who were matched in age, weight and body build were selected and tested on four different occasions separated by 14 days. On the first day of testing, the subjects were randomly separated into Groups A (0.75 mL fruit juice/kg + 100 mg tapioka dried cassava product: n = 25), Group B (0.75 ml ethanol/kg+ 100 mg tapioka: n = 25), Group C (0.75 mL ethanol/kg + 100 mg vitamin E:n = 25) and Group D (0.75 mL fruit juice/kg + 100 mg vitamin E: n = 25) and were treated as indicated. The ethanol administered was diluted to 30% with fruit juice. Each participant was rotated every forthnight until he/she completes the four rounds of testing. The data obtained show that the co-administration of ethanol and vitamin E significantly reduced (p<0.05) the level of serum uric acid and the proportion of subjects in the prehypertension and stage 1 hypertension classes induced by ethanol consumption alone. Apart from confirming the recent proposal that links ROS to hyperuricemia and secondary cardiovascular disorders, this study suggests that boosting the level of antioxidant vitamins in the body could alleviate the ethanol-induced hyperuricemia and perhaps, associated disease conditions.
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