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Articles by Heng Wu
Total Records ( 2 ) for Heng Wu
  Ruo-Xi Zhang , Yong Peng and Heng Wu
  With pipe racking device of offshore drilling platform as object of the research, this study builds its kinematic model on the basis of its actual motion in the pipe racking process and solves this model by the method of homogeneous coordinate transformation, then the position and posture of the PRS end effector (clamp) during the racking procedure can be achieved which is relative to the inertial reference system. The motion track and the displacement, velocity and acceleration curves of clamp are acquired by MATLAB software. The kinematic parameters of this mechanism are analyzed comparatively when the joints are in the three different motion modes: Uniform velocity, uniform acceleration-uniform deceleration and uniform acceleration-uniform velocity-uniform deceleration.
  Jose A. Adams , Heng Wu , Jorge A. Bassuk , Jaqueline Arias , Arkady Uryash and Paul Kurlansky
 

Introduction: Periodic acceleration (pGz) is a non-invasive method of increasing pulsatile shear stress to the endothelium. pGz is achieved by the sinusoidal head to foot motion to the supine body. pGz increases endogenous production of nitric oxide in whole animal models and isolated perfused vessel preparations, and is cardioprotective when applied prior to, during and after ischemia reperfusion. In part, the protective effects of pGz are attributable to nitric oxide (NO). The purpose of this investigation was to determine whether pGz up-regulates NOS isoforms in the endomyocardium. Methods and results: Fifteen swine weight 15–20kg, were anesthetized, instrumented to measure hemodynamics and randomized. Ten animals received 1h of pGz at 180cycles/min and Gz±3.9m/s2 [pGz] in addition to conventional ventilatory support and five served as time controls. Results: pGz produced a 2.3±0.4 and a 6.6±0.1 fold significant increase in eNOS and phosphorylated eNOS, 3.6±1.1 fold increase in nNOS, and no significant change in iNOS. pGz also produced a 2.4±0.3 and 3.9±0.2 folds significant increase in both total(t-Akt) and phosphorylated (p-Akt) Akt. Conclusions: pGz is associated with an increase in both total and phosphorylated eNOS and nNOS protein expression in endomyocardium, and induced significant increase in total and phosphorylated-Akt. The data indicates that pGz is a novel method to induce eNOS and nNOS production in the endomyocardium. Therefore, pGz may serve as a powerful non-invasive intervention to activate the beneficial cardiac effects of endothelial and neuronal NOS.

 
 
 
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