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Articles by Hend A. Essa
Total Records ( 2 ) for Hend A. Essa
  Doha A. Mohamed , Sherein S. Abdelgayed , Rasha S. Mohamed and Hend A. Essa
  Background and Objective: Hyperthyroidism and hypothyroidism are the most common disorders of thyroid function. The current study aimed to evaluate the prophylactic effect of safflower petals and moringa leaves crude ethanol extracts against thyroid dysfunctions (hyper and hypothyroidism). Materials and Methods: Forty-two rats were divided into 7 groups, control normal, hyperthyroidism control, hyper-safflower, hyper-moringa, hypothyroidism control, hypo-safflower and hypo-moringa. L-Thyroxine (0.3 mg kg1 b.wt.) and carbimazole (10 mg kg1 b.wt.) were orally administrated for 3 weeks as hyperthyroid and hypothyroid inducer, respectively. Blood hemoglobin, plasma thyroid-stimulating hormone (TSH), glucose, catalase activity, lipid profile as well as liver and kidney functions were assessed. Histological examination of thyroid gland was carried out. Results: The results revealed that hyper and hypothyroidism mediated decrease and increase in TSH values, respectively. Oral administrations of either safflower petals extract or moringa leaves extract improve plasma levels of TSH. Oxidative stress and disturbance in plasma glucose, lipid profile as well as liver and kidney functions were occurred in conjunction with thyroid dysfunctions especially hypothyroidism. Administration of safflower petals extract or moringa leaves extract alleviates the reduction in catalase activity, hyperglycemia and disturbance in lipid profile as well as liver and kidney functions accompanied with thyroid dysfunctions especially hypothyroidism. Conclusion: The studied extracts have prophylactic potential against thyroid dysfunctions and the subsequent oxidative stress, hyperglycemia and changes in lipid profile. Crude ethanol extract of safflower petals was promising as prophylactic agents in hyper and hypothyroidism as observed by improving plasma levels of TSH, lipid profile and histopathological changes.
  Doha A. Mohamed , Sherein S. Abdelgayed , Hend A. Essa and Rasha S. Mohamed
  Background and Objective: Non-alcoholic fatty liver disease (NAFLD) is a public health problem presenting one of the most important common forms of liver diseases worldwide. This study was carried out to investigate the protective effect of two functional foods in form of bread containing purslane seeds meal and garden cress seeds against NAFLD. Materials and Methods: High fat and high cholesterol diet were used for induction of NAFLD in rats for 6 weeks. Plasma lipid profile (total cholesterol, triglycerides, high density lipoprotein-cholesterol and low-density lipoprotein-cholesterol, hepatic lipid profile (total fat, cholesterol, triglycerides), malondialdehyde (MDA), as well as liver (AST, ALT, total and direct bilirubin) and kidney (creatinine and urea) functions were assessed. Histological examination of liver tissue was carried out. Results: Results revealed that significant elevation in plasma and liver lipid profiles, MDA, liver enzymes (AST and ALT), bilirubin (total and direct) and kidney function (creatinine and urea) were observed in NAFLD control compared to normal control. Feeding rats on diet containing functional food I and II (purslane and garden cress bread, respectively) showed significant improvement in all the studied parameters with remarkable effect regards to functional food I (purslane bread). Conclusion: Purslane bread and garden cress bread as functional foods prepared in the present study prevent weight gain, improve plasma lipid profile and prevent hepatic lipid accumulation effectively in NAFLD model in rats. Also decreased lipid peroxidation, improve liver and kidney functions and possess hypoglycemic effect. Purslane bread was superior in the prevention of hepatic lipid accumulation.
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