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| Articles
by
Hasan KAFALI |
Total Records (
1 ) for
Hasan KAFALI |
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Ozlem KIRMEMIS
,
Mustafa Mansur TATLI
,
Cuneyt TAYMAN
,
Cemile KOCA
,
Ahmet KARADAG
,
Nurdan URAS
,
Ugur DILMEN
and
Hasan KAFALI
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Aim: To test the hypothesis that serum S100B levels could be useful in detecting neurological
damage in infants with intrauterine growth retardation (IUGR). Materials and methods:
The study group consisted of infants with IUGR and the control group consisted
of age-matched healthy infants. S100B protein levels were measured after birth
and compared between groups. Results: For this study, 43 infants with IUGR and
25 infants as a control group were recruited. Gender, gestational age, type of
delivery, and maternal age of the groups were statistically insignificant, with
the exception of the mean birth weights (2120 ± 450 g in the IUGR group
and 3096 ± 570 g in the control group (P < 0.001), respectively). S100B
protein levels of the IUGR infants (1.13 ± 0.54) were significantly higher
than those of the control group (0.45 ± 0.13) (P < 0.001). IUGR infants
treated with antenatal steroids showed lower S100B levels than IUGR infants that
did not receive antenatal steroid treatments (P < 0.05). The study group infants
were divided into 2 groups, for growth retardation (GR) that was asymmetric (n
= 15) and symmetric (n = 28). The asymmetric and symmetric GR infants’
S100B levels were 1.14 ± 0.47 pg/mL and 1.21 ± 0.34 pg/mL, respectively,
and no significant differences were found between the 2 groups in terms of S100B
levels (P = 0.32). Conclusion: The results of this study favor the opinion that
there is an existing intrauterine hypoxia causing hypoxic brain tissue damage
in IUGR infants, even when followed up with modern obstetrical screening protocols.
Measurements of S100B may be useful in the prediction of outcome in these infants. |
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