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Articles by Hanung Puspita Adityas
Total Records ( 1 ) for Hanung Puspita Adityas
  Elin Yulinah Sukandar , Neng Fisheri Kurniati , Khairunnisa Puspatriani and Hanung Puspita Adityas
  Background and Objective: Curcumin has long been known to have an antibacterial activity. The main objective of this study was to evaluate the antibacterial activity of curcumin in combination with tetracycline or ciprofloxacin against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and its underlying mechanism. Methodology: The antibacterial activity of the combination of curcumin with tetracycline or ciprofloxacin was determined using the checkerboard method. Furthermore, the antibacterial activity of the chosen combination was determined in situ by the recovery rate and wound score of S. aureus-infected rabbit’s skin following the curcumin-antibiotic combination treatment. Lastly, imaging using scanning (SEM) and transmission (TEM) electron microscopy was done to determine the morphological changes of the curcumin combination-treated S. aureus. Data were analyzed by using one-way ANOVA followed by LSD and Tukey post hoc analysis using SPSS. Results: The results of this study show that combinations of curcumin with tetracycline had a synergistic interaction against S. aureus and E. coli, while a combination of curcumin with only ciprofloxacin showed a synergistic interaction on S. aureus. The combination of curcumin and tetracycline was then chosen for further studies. According to dermal and ocular irritation tests on rabbits, an ointment based on a combination of curcumin with tetracycline did not cause dermal or ocular irritation. Furthermore, the application of a combination of 2% curcumin with 1% tetracycline on S. aureus-infected rabbit’s skin healed the infected skin faster than the 3% tetracycline ointment alone. This combination was found to cause a distortion and rupture of the bacterial cell wall after being treated with the combination for 18 h. Conclusion: Curcumin in combination with tetracycline can be an alternative topical application in the treatment of S. aureus-caused skin infections.
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