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Articles by Hanefi Ozbek
Total Records ( 4 ) for Hanefi Ozbek
  Hanefi Ozbek , Irfan Bayram , Mustafa Ozturk , Ender Erdogan , Suleyman Alici and Ismail Uygan
  This study aimed to investigate the cancerogenic effect of salted-fish samples (Chalcalburnus tarichi) on male and female mice. Eighty mice were fed with either salted fish and standart rat pellets separately (n=40) or only standart rat pellets (n=40) for 383 days. It was observed that the whole salted fish was eaten hungrily by mice. One mouse from each group and each sex were sacrificed in every month and liver, heart, esophagus, stomach, intestines, kidneys, testes and breasts were examined histopathologically. Serum BRMA (CA 15-3) (for breast cancer), GI-MA (CA 19-9) (for pancreatic and colo-rectal cancer), OMMA (CA 125) (for ovarian cancer) and CEA (for colo-rectal cancer) levels were measured as tumor markers. There was no histopathological or biochemical evidence of GI cancer in mice fed with salted fish. Only one animal developed lung cancer as a malignancy. Salted fish appears to have no association with GI cancer in mice.
  lker Durak , Hanefi Ozbek , Erdinc Devrim and Asl han Avc
  Investigation of possible effects of NADH supplementation on hematological and blood biochemical parameters and on oxidant/antioxidant status in some tissues including liver, kidney and heart was aimed in this study. Fourteen Sprague-Dawley type rats of 2 months old were used throughout the study. Seven rats were fed on NADH containing foods for a month and the others were fed on the same food diet except NADH. After a month, blood samples were obtained before animals were sacrificed. Their liver, heart and kidney tissues were removed to be used in the analyses of oxidant/antioxidant parameters. In the NADH group, lowered erythrocyte, leukocyte, platelet, hemoglobin and hematocrit values were observed as compared with control group. Furthermore, increased malondialdehyde and oxidation sensitivity values were measured in the heart tissues from NADH supplemented group. Serum LDH activity was also found to increase in the study group. In conclusion, NADH supplementation causes anemia and leukopenia and leads to increased peroxidation reactions in the heart tissue.
  Hanefi Ozbek
  The aim of this study was to gas chromatographic analysis of extract of Foeniculum vulgare L. essential oil and to investigate its median lethal dose (LD50) and possible anti-inflammatory effects. The composition of the essential oil was as follows: 74.8% (E)-anethole, 11.1% limonene, 4.7% methyl chavicol, 2.5% fenchone and 1.3% α-pinene. The LD50 dose was found to be 1.038 mL kg-1. The essential oil of Foeniculum vulgare L. was investigated the model of carrageenan induced rat paw edema and it had an anti-inflammatory effect matching to that of etodolac at 0.050 and 0.200 mL kg-1 doses.
  Hanefi Ozbek , Beyhan Eryonucu and Niyazi Guler
  This study was designed to compare vasorelaxant effects of the sildenafil and verapamil on isolated rat aorta. Endothelium intact and denuded aortic rings were suspended in organ chambers. Sildenafil (10-10 to 10-4 M) induced a dose-dependent vasodilation of phenylephrine precontracted aortic rings. Relaxation of endothelium intact and denuded aortic rings caused by 10-4 M sildenafil was about 96 and 79%, respectively. Verapamil (10-10 to 10-4 M) induced a dose-dependent vasodilation of phenylephrine precontracted aortic rings. Relaxation of endothelium intact and denuded aortic rings caused by 10-4 M verapamil was about 99 and 98%, respectively. In the phenylephrine precontracted aortic rings, pD2 values for sildenafil were 4.93±0.59 and 4.11±0.62 in the presence and absence of endothelium, respectively. The pD2 values for verapamil were not different in the presence and absence of endothelium (5.15±1.05 vs 4.96±1.14). Verapamil and sildenafil showed a similar degree of vasorelaxant effect in the intact aortic rings, although there was a significant difference in the degree of relaxation in the absence of endothelium (98 vs 79%). Sildenafil induced both endothelium-dependent and independent vasorelaxation on the aortic rings. Although, there was no significant difference in the degree of relaxation induced by verapamil and sildenafil in aortic rings with intact endothelium, verapamil has more relaxing effect in the denuded aortic rings.
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