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Articles by H.R. Rahimi
Total Records ( 5 ) for H.R. Rahimi
  H.R. Rahimi , M. Gholami , H.R. Khorram-Khorshid , F. Gharibdoost and M. Abdollahi
  Hepatoprotective effect and mechanisms of a novel selenium/electromagnetically treated multiherbal mixture named Setarud (IMODTM) in combination with silymarin (SM) a known hepatoprotective compound was investigated in acetaminophen-induced acute hepatic failure rat model. Animals were divided into five groups and pre-induced with phenobarbital (0.1 mg kg-1, i.p.) before administration of a single dose of acetaminophen (1 g kg-1, i.p.) except group 1 which was considered as normal. Group 2 was remained without treatment and considered as control while groups 3 to 5 were treated with SM (50 mg kg-1, p.o.), IMOD (30 mg kg-1, i.p.) and IMOD+SM, respectively 24 h post administration of acetaminophen. Blood was collected at 0, 24 and 72 h post acetaminophen treatment. Elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) confirmed hepatic failure induced by acetaminophen. After 48 h of treatment, the rats were anesthetized and the liver was removed and the right lobule was homogenized and then measured for catalase (CAT), malondialdehyde (MDA) and glutathione (GSH) value. Part of liver was left in paraffin for histopathology examination. CAT and GSH were significantly decreased in the acetaminophen-treated group while ALT, AST, ALP and MDA increased when compared to normals. Histopathological examination of acetaminophen-treated animals showed necrosis, inflammation, hyperplasia of kupffer and infiltration of mononuclear cells, dilation of sinusoids and disruption of hepatocytes, while treatment with IMOD+SM normalized protected hepatic architecture in accordance to biochemical results. Treatment of animals with IMOD and SM alone or in combinations considerably protected the hepatic failure by diminishing ALT, AST, ALP and MDA. Both IMOD and SM and their combination improved acetaminophen-induced histopathological hepatic damage. Conclusion is that combination of IMOD and SM considerably protect from acute hepatic failure via enzymatic and non-enzymatic mechanisms.
  H.R. Rahimi , M. Arastoo and M. Shiri
  Helicobacter pylori (H. pylori) is the bacterium responsible for many gastric disorders such as gastritis, gastric ulcer and gastric cancer. Half of the world's population is infected with H. pylori. Interestingly, the use of medical plants such as Punica granatum (P. granatum), commonly known as pomegranate, are being increasingly used throughout the world because of their efficacy and low toxicity. Studies have reported the antibacterial, anti-inflammatory and anticancer activities of P. granatum by various mechanisms including anti-adhesive, regulation of proliferation, cell survival, motility, invasion, apoptosis and cell-cycle pathways, increase in JNK phosphorylation and caspase-3 enzyme activity, decrease Akt and mTOR activation as well as inhibitory effects on IL-1β and NF-kB. Therefore, it can be suggested that P. granatum may reduce gastric diseases by eradication of H. pylori and also, it may reduce gastric disease symptoms and inhibit the progression of these diseases by its valuable properties. Our hypothesis will be confirmed in the future by experimental investigations such as using P. granatums alone or in combination with other drugs to create an herbal medicine for the prevention of gastric disease development which is induced by H. pylori.
  S. Fouladdel , E. Azizi , H.R. Rahimi and S.N. Ostad
  Genetic differences among tumor cells of breast cancer patients are the main reasons for therapeutic failure. COX-2 and aromatase proteins have been determined to be important in breast cancers as potential targets for prevention and can also be a part of the therapeutic regimen of these cancers. Consequently, we decided to determine the expression of these proteins in human breast cancer T47D cells and its established tamoxifen resistant subline, namely T47D/TAMR-6 cells. Immunocytochemical technique was employed using primary antibodies for each protein followed by visualization of results with LSAB2 detection kit under the microscope. Our data showed that expression of COX-2 was relatively the same in parent and resistant T47D cells in the presence and absence of Tamoxifen (1 uM). Unlike tamoxifen, celecoxib could dramatically decrease the expression level of COX-2 in both cell types. Aromatase protein expression seems to be absent or is expressed at very low levels in both cell types and under all experimental conditions. Our data indicates no significant difference between studied cell types with respect to expression of aromatase and COX-2 enzymes. Therefore, these data suggest different possible outcomes for specific inhibitors of these enzymes alone or in combination with tamoxifen in the therapeutic regimen of breast cancer patients.
  A.H. Abdolghaffari , S. Nikfar , H.R. Rahimi and M. Abdollahi
  Although, positive role of special bacteria in induction of Inflammatory Bowel Disease (IBD) including Ulcerative Colitis (UC) and Crohn’s Disease (CD) have been demonstrated in several studies but the consensus on etiology of IBD and beneficial effect of antibiotics has not been reached yet. And, also, no well-designed clinical trials in this regard have been done yet. This review focuses on various clinical trials which have been done in according to beneficial use of antibiotics in UC and CD from 1978 to date. For this purpose, all electronic databases such as PubMed, Scopus, Google Scholar and Cochrane library were searched. The results of clinical trials suggested that metronidazole, ciprofloxacin or the combinations of these antibiotics are effective in CD. However, ciprofloxacin is the first choice, because it has good coverage on gram negative and anaerobic bacterium which plays an important role in CD. However, there is a controversy on the use of antibiotics in UC and the efficacy of them in long-term treatment of UC is still in doubt. Various antibiotics such as anti-tuberculosis, macrolides (clarithromycin), fluoroquinolones, 5-nitroimidazoles, rifaximin, rifamycin derivatives (rifampin), aminoglycosides (tobramycin), rifabutin, clofazimine, tetracyclines (tetracycline and doxycycline) and vancomycin have been under attention of researchers in the recent years. Furthermore, other antibiotics with lower cost and adverse effects, effectiveness and availability are the third generation of cephalosporins and gentamicin and also penicillin or clindamycin that should be evaluated in future studies.
  A. Balouchzadeh , H.R. Rahimi , A.R. Ebadollahi-Natanzi , B. Minaei-Zangi and O. Sabzevari
  The aim of this study was to examine the protective effects of Iranian green tea aqueous extract (GTE) (Camellia sinensis) in chronic ethanol toxicity using rat model. Animals were divided into four groups and fed for 30 days by gavage technique: A (Control), B (Ethanol-15% (v/v)), C (Ethanol + GTE) and D (GTE-2.5% (w/v)). Aspartate aminotransferase (AST, 158%), alanine aminotransferase (ALT, 131%), alkaline phosphatase (ALP, 159%), γ-glutamyltranspeptidase (GGT, 89%) and malondialdehyde (MDA, 53%) values were significantly (p<0.01) increased in the ethanol group (B) as compared to the control (A). Treatment of animals with GTE, however, considerably (p<0.05) protected the liver damage by decreasing AST (32%), ALT (33%), ALP (26%), GGT (47%) and MDA (59%) values. GSH concentration was significantly decreased in the ethanol group as compared to the control (40%) but considerably recovered (58%) following GTE treatment. Furthermore, histopathological observations, consistent with biochemical findings, showed that GTE treatment significantly reduced portal inflammation and infiltration of mononuclear cells pronounced by ethanol.
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