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Articles by H.A.B. Coker
Total Records ( 3 ) for H.A.B. Coker
  S.A. Adesegun , N.A. Elechi and H.A.B. Coker
  Methanolic extract of Macaranga barteri Mull-Arg (Euphorbiaceae) was investigated for antioxidant properties using different in vitro tests, including DPPH free radical scavenging, reducing, inhibition of linoleic acid lipid peroxidation, iron chelating power. The total phenolic content was also determined and expressed in gallic acid equivalent. The antioxidant activities increased with increasing concentration of the extract to certain extent then level off with further increase. The radical scavenging activity of the extract was comparable to that of BHT and ascorbic acid and no significant difference between them (p>0.05). The extract of M. barteri showed strong inhibition of lipid peroxidation in linoleic acid system and moderate reducing properties. It demonstrated poor iron chelating capacity compared to EDTA used as positive control, suggesting metal chelation plays very little role in antioxidant properties of the extract. This study showed that the leaf extract of M. barteri is a potential source of antioxidants.
  A. Akintonwa , O. Awodele , A.T. Olofinnade , C. Anyakora , G.O. Afolayan and H.A.B. Coker
  Problem statement: The pharmaceutical industry is a major contributor to industrial wastes globally. Effluents from this industry are usually discharged into the environment and when not properly handled and disposed, they affect both human health and the environment. Approach: This study evaluated the mutagenic potentials of effluents from six pharmaceutical companies in the Lagos province of Nigeria using modified Ames test and Allium cepa (Linn) assay. Allium cepa model was used to determine the mean root length, mitotic index and chromosomal aberrations effects of these plants on Onion bulbs using 5, 10 and 15% concentration of the pharmaceutical effluents. The modified Ames test which is a modification of the standard Ames test was done using E. coli (0157:H7) that has the phenotypic characteristics of glucose and lactose fermentation, motile, urease negative, indole positive and citrate negative. Result: From the results, two of the effluents showed mutagenicity with modified Ames test and all the six effluents showed mitodepressive and toxic effects to the Allium cepa root. Conclusion/Recommendations: It may then be recommended that pharmaceutical companies should devise means of containing, treating and managing their effluents.
  S.A. Adesegun , N.A. Elechi and H.A.B. Coker

The stem bark extract of S. ellipticum (Hochst) Pax was investigated for its antioxidant properties in this study. The extract was evaluated for antioxidant activity in vitro in terms of its ability to inhibit lipid peroxidation and its free radical scavenging, reducing and metal chelation powers. The total amount of phenolic compounds in the extract was also determined in terms of gallic acid equivalent. The extract produced effective free radical scavenging and reducing activities in a dose dependent fashion. The extract exhibited noticeable inhibition of lipid peroxidation of linoleic acid emulsion. These activities were less than that of ascorbic acid and 2,6–Di–tert–butyl–47–methylphenol used as positive controls. The extract however demonstrated poor iron chelating ability compared to ethylene diamine tetraacetic acid. The total phenolic content of the extract was 50.61±0.08 mg g-1 in terms of gallic acid. This study showed that the stem bark extract of S. ellipticum exhibits significant antioxidant activity and is a good source of natural antioxidants.

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