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Articles by H. Jiang
Total Records ( 5 ) for H. Jiang
  H. Jiang , J. Wang , L. Che , Y. Lin , Z. Fang and De Wu
  The objective of this study was to investigate the effects of different calcium sources and levels on performance and bioavailability of calcium and phosphorus in weaning piglets. A total of 90 LY (LandracexYorkshire) weaning piglets were randomly assigned to 2x8 factorial completely randomized arrangement. The two calcium sources were calcium carbonate or calcium citrate; Eight dietary calcium levels were 0.37, 0.50, 0.60, 0.70, 0.80, 0.90, 1.00 and 1.10%. Each treatment consisted of 3 replicate pens of 2 piglets. Digestibility trial was conducted from 29 to 32 day of experiment using the total collection method. No significant difference was observed on average daily gain, average daily feed intake and feed conversion rate in piglets (p>0.05) from calcium sources or interactions between calcium sources and calcium levels. There was a quadratic response of average daily gain to increasing calcium levels (p<0.05), with the optimum dietary calcium level of 0.6%. Piglets receiving dietary ranging from 0.37 to 0.80 had a higher calcium, phosphorus apparent digestibility than piglets receiving dietary ranging from 0.90 to 1.10%. Calcium citrate had significantly higher calcium apparent digestibility than calcium carbonate in piglets (p<0.05). It is concluded that calcium citrate is a good calcium source with comparable in bioavailability as calcium carbonate for weaning piglets. The piglets fed 0.6% calcium grew better, regardless of dietary calcium source.
  B. H. R. Wolffenbuttel , L. J. Klaff , R. Bhushan , J. L. Fahrbach , H. Jiang and S. Martin
  Aims  To compare starter insulins in the elderly subgroup of the DURABLE trial 24-week initiation phase.

Methods  In a post-hoc analysis of the ≥ 65 years subgroup enrolled in the DURABLE trial, we compared the safety and efficacy of lispro mix 25 (LM25: lispro 25%/insulin lispro protamine suspension 75%), n = 258, vs. glargine, n = 222, added to oral glucose-lowering agents.

Results  Baseline glycated hemoglobin (HbA1c) was similar (LM25 8.7 ± 1.2, glargine 8.8 ± 1.1%, P = 0.612). At 24-weeks, LM25 patients had lower HbA1c (7.0 ± 0.9 vs. 7.3 ± 0.9%, P < 0.001), greater HbA1c reduction (−1.7 ± 1.2 vs. −1.5 ± 1.1%, P < 0.001), and more patients reaching HbA1c < 7.0% (55.6 vs. 41.0%, P = 0.005). LM25 patients were on more insulin (0.40 ± 0.19 vs. 0.33 ± 0.19 u/kg/day, P < 0.001) and experienced more weight gain (3.6 ± 3.6 vs. 1.8 ± 3.2 kg, P < 0.001). Additionally, LM25-treated patients reported a higher mean overall hypoglycaemia rate than glargine patients (40.8 ± 47.6 vs. 31.1 ± 48.5 episodes/patient/year, P = 0.037), while nocturnal hypoglycaemia rates were similar. Over 24 weeks, incidence of severe hypoglycaemia was higher for LM25 (4.3% vs. 0.9%, P = 0.018); however, by 24-week endpoint incidence was similar (0.8% vs. 0.0%P = 0.125).

Conclusions  In this elderly subgroup post-hoc analysis, LM25 demonstrated a lower endpoint HbA1c and a higher % of patients reaching HbA1c target of < 7.0%, but with more weight gain and higher rates of hypoglycaemia compared to glargine.

  C.D. Gilbert , Y. Bai and H. Jiang
  Studies were conducted to evaluate the FDA and USDA-approved Cecure® antimicrobial in a post-immersion chill drench application in four broiler processing facilities. Control and Cecure®-treated carcasses were collected and stored on-site under typical commercial refrigerated storage conditions. On the day of treatment and on subsequent storage days, log10 APC (CFU/mL) were enumerated on control and Cecure®-treated carcasses. In three of the four plants, treatment with Cecure® resulted in a significant reduction in log10 APC of 1.1 to 3.4 CFU/mL on Day 0. In all plants the Cecure® treatment resulted in a slight extension (1 to 2 days) in carcass shelf life at 1 to 7°C. Additionally, in one plant the effect of the Cecure® treatment was evaluated on cut-up poultry parts from Cecure®-treated carcasses. Initial reductions in log10 APC were statistically significant for thighs and boneless, skinless breast meat on Day 0 and slight extensions in product shelf life (1 to 2 days) were noted for wings, thighs, leg quarters, split breasts and boneless, skinless breast meat from Cecure®-treated carcasses. Multiple regression analysis of the slopes of the exponential growth portion (log phase) of the bacterial growth curves for the control and Cecure®-treated carcasses and parts showed no significant difference in the slopes of the growth curves. Thus, any extension in shelf life of Cecure®-treated carcasses or parts was due to initial microbial reductions at the time of treatment, demonstrating no continued technical effect during refrigerated storage.
  S Eleswarapu , X Ge , Y Wang , J Yu and H. Jiang

IGF-I is abundantly expressed in the liver under the stimulation of GH. We showed previously that expression of hepatocyte nuclear factor (HNF)-3, a liver-enriched transcription factor, was strongly stimulated by GH in bovine liver. In this study, we determined whether GH-increased HNF-3 might contribute to GH stimulation of IGF-I gene expression in bovine liver and the underlying mechanism. A sequence analysis of the bovine IGF-I promoter revealed three putative HNF-3 binding sites, which all appear to be conserved in mammals. Chromatin immunoprecipitation assays showed that GH injection increased binding of HNF-3 to the IGF-I promoter in bovine liver. Gel-shift assays indicated that one of the three putative HNF-3 binding sites, HNF-3 binding site 1, bound to the HNF-3 protein from bovine liver with high affinity. Cotransfection analyses demonstrated that this HNF-3 binding site was essential for the transcriptional response of the IGF-I promoter to HNF-3 in CHO cells and to GH in primary mouse hepatocytes. Using similar approaches, we found that GH increased binding of the signal transducer and activator of transcription 5 (STAT5) to the HNF-3 promoter in bovine liver, that this binding occurred at a conserved STAT5 binding site, and that this STAT5 binding site was necessary for the HNF-3 promoter to respond to GH. Taken together, these results suggest that in addition to direct action, GH-activated STAT5 may also indirectly stimulate IGF-I gene transcription in the liver by directly enhancing the expression of the HNF-3 gene.

  H. Jiang , W. Q. Zhan , X. Liu and S. X. Jiang
  The antioxidant properties of the various extracts and flavonoids prepared from Oxytropis falcate Bunge were investigated by 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. In the chloroform, ethyl acetate and n-butanol extracts, the ethyl acetate extract exhibited the highest antioxidant activity (IC50 = 2.05 mg mL-1). Furthermore, rhamnocitrin, kaempferol, rhamnetin, 2′,4′-dihydroxychalcone and 2′,4′, β-trihydroxy-dihydrochalcone were purified from chloroform and ethyl acetate extracts. The radical-scavenging activities of the five compounds were also measured and the results showed that kaempferol (IC50 = 0.11 mg mL-1), rhamnetin (IC50 = 0.14 mg mL-1) and rhamnocitrin (IC50 = 0.15 mg mL-1) exhibited considerable antioxidant activities, but the antioxidant activities of the two dihydrochalcones were very weak. Although these flavonoids are known, this is the first report of antioxidant activity in this plant.
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