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Articles by G.I. Olasehinde
Total Records ( 3 ) for G.I. Olasehinde
  G.I. Olasehinde , D.K. Akinlabu , F.T. Owoeye , E.F. Owolabi , O.Y. Audu and R.C. Mordi
  Objective: The aim of this project is to extract the chemical components of various parts of this tree and to characterize the constituents of these extracts and to test for their biological activity. Methodology: Agar-well diffusion assay was used to determine the antimicrobial activity of the oil extract on the test isolates: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus cereus and the yeast Candida albicans. The Minimum Inhibitory Concentration (MIC) for each test organism was determined by the broth dilution method using 0.5 McFarland’s standard. Results: Preliminary proximate and phytochemical analysis of the oil extracts from the seed showed the presence of the following minerals, Na, K, Ca, Mg, Mn, Fe, Cu and Zn as well as the following family of compounds: Steroids, saponin and terpenoids. Antimicrobial and antibacterial studies also revealed that the oil extract was active against Gram’s negative and positive bacteria and fungi. The test organisms were Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus cereus and the yeast Candida albicans. Pseudomonas aeruginosa was resistant to the oil extract at all the concentrations used. Conclusion: Amongst the bacteria used, highest MIC of 150 mg mL–1 was recorded for Staphylococcus aureus, while lowest MIC of 50 mg mL–1 was observed in E. coli. Highest activity was observed against the fungus, Candida albicans with MIC of 25 mg mL–1.
  G.I. Olasehinde , J.A. Akinyanju and A.A. Ajayi
  Studies were carried out to determine the disinfectant property of naphthol and its derivatives. The sensitivity of some clinical organisms as compared with the activity of some selected commercial disinfectants was tested. The methods employed for assessing the efficacy of disinfectants in this study are Minimal Inhibitory Concentration (MIC) Test and Capacity Use Dilution Test. The clinical organisms used for the tests are Pseudomonas aeruginosa, Salmonella typhi and Proteus mirabilis while the commercial disinfectants used are Dettol (Chloroxylenol), Savlon (Cetrimide/chlorhexidine mixture) and TCP (Trichlorophenol) and the Naphtholics are alpha naphthol and 2-amino-1,4-naphthoquinonimine hydrochloride. Dettol showed highest antibacterial activity against all the test organisms. Savlon`s antibacterial activity was high against the test organisms except Pseudomonas aeruginosa. TCP showed low activity against all the test organisms while Purified ∞-naphthol and its derivative, 2-amino-1, 4-naphthoquinonimine hydrochloride were found to exhibit disinfecting properties, with the derivative showing more antimicrobial activity than ∞-naphthol. The compounds have bactericidal effect against the test organisms used in this study.
  G.I. Olasehinde , D.O. Ojurongbe , O.J. Akinjogunla , L.O. Egwari and A.O. Adeyeba
  High transmission rate and drug resistance have been implicated in the spread and re-emergence of malaria in areas where the disease had been eradicated. The objective of this study was to determine the prevalence of falciparum malaria and pre-disposing factors to malaria among patients presenting with fever in selected State Hospitals in Ogun State, Southwestern Nigeria. Four thousand and sixty six patients were recruited into this study. Scientific and Ethical clearance was obtained for this study. Blood samples were collected for malaria screening from the subjects. Structured questionnaires were administered to patients and parents of infants to determine the factors that could lead to the development of drug resistance by the parasite in the study population. Out of 4066 subjects screened during the study period, 61.1% were positive for falciparum malaria. Highest prevalence of 70.8% was recorded in children 1-5 years, also the group with highest parasitemia (1080). The study showed that 24.6% of the patient visited hospitals for treatment, 12% use local healers while 25.0% bought antimalarial drugs without prescription. Moreover, some subjects use more than one method in their management of malaria. Those who combined antimalarial drugs with traditional medicine from local healers were 17.4%. Only 18% of the sample population used insecticide treated mosquito nets, 42.3% used window and door nets, while 13% did not employ any mosquito preventive method. Uncontrolled use of drugs and exposure of parasites to the drugs should be monitored in areas where the parasite is still sensitive to the drug.
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