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Articles by G. Elaiyaraja
Total Records ( 2 ) for G. Elaiyaraja
  M. Gopi , R. Dhinesh Kumar , G. Elaiyaraja , K. Karthik , H.V. Manjunatha Char , K. Gautham , R. Jaydip and M.R. Purushothaman
  The essentiality of nutrients keeps on changing with the advancement in nutritional research and genetic gain. The genetic gain especially in poultry sector is very high which results in increase in nutrient requirement of both the essential and non-essential nutrients. For the rapid growth the requirement of essential nutrients reaches many folds which are in direct relation with the performance, but the requirement for non-essential nutrients is an indirect one. Most of the dispensable amino acids, vitamin C, carnitine, etc. which are being synthesized endogenously are now a days unable to meet the birds requirements that warrants the dietary supply. Another important nutrient is coenzyme Q10 (CoQ10) which endogenously synthesized is now gaining much attention as a supplement for fast growing broilers. The CoQ10 can be termed as multi-functionary as each and every cell in the body needs this but quantity is being high for very active organs like heart, lungs, liver, kidney, etc. They are essential for cellular oxidative phosphorylation and regenerative antioxidant. The supplementation of CoQ10 improved the feed efficiency with reducing the electron leaks from mitochondria and increases total antioxidant capacity. For this property, CoQ10 is widely used in human medicine especially persons suffering from cardiac, neurological disorder, hypercholesterolemic condition and also even in cancer. The CoQ10 in poultry draws first attention when it is found to reducing the ascites mortality in marketable broilers. Thereafter, the advantages of CoQ10 is started to exploit with much attention to ascites, feed efficiency, cholesterol lowering effect nutraceutical and nutrigenomic property both in poultry and swine industry.
  I. Mohanty , K. Arunvikram , D. Behera , A. Arun Prince Milton , G. Elaiyaraja , G. Rajesh and K. Dhama
  The evolution of poison and venom had made the animal body system to deal effectively with defense mechanism primarily by molecular means. These chemical defences target the cell membrane receptors, block the physiological systems in body and cause paralysis. Evolution around years, led to the development of these peptides with effective functional properties that made them more selective and potent, but immunogenically poor, provide prolonged action and potent effect on preys. When a venom or toxin is enriched with these functionally effective peptides form 3D structure that are linked by disulphide brides. This structure is highly stable and they specifically target GPCRs, ion channels and other membrane receptors and it was proved to have indispensable pharmacological properties. The first drug Captopril discovered against hypertension was isolated from Brazilian viper, Bothrops juraraca. It is one of the most popular and accepted antihypertensive drug used world wide now-a-days. Since then peptides isolated from snake, scorpion, spider, bee and sea anemone toxin have proved to display potential immunomodulatory effects and were useful in treating rheumatoid arthritis, multiple sclerosis, lupus and psoriasis including autoimmune diseases in human. The present article in not intended to be a definitive review of entire field of zootoxins, but rather an overview, which emphasize on recent developments made in the field of zootoxins (venoms and toxins), their role in the treatment of diseases with a special focus towards exploring their potent immunodulatory and therapeutic potential in the field of drug development. Advances in the fields of analytic chemistry, molecular biotechnology and biochemistry are now making it possible to isolate and purify individual components, using a minute amount of a toxin.
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