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Articles by F. Zhang
Total Records ( 8 ) for F. Zhang
  H Tang , F Chen , Q Tan , S Tan , L Liu and F. Zhang

Polycomb repressive complex 2 (PRC2), which mediates trimethylation of lysine 27 on histone H3 (K27me3), plays an important role in many types of stem cell differentiation. Here, we try to reveal how PRC2, PRC2-mediated repressive histone marker H3K27me3, and active histone marker histone H4 acetylation (acH4) regulate the CD11b transcription during all-trans retinoic acid (ATRA)-induced HL-60 leukemia cell differentiation. By using quantitative real-time polymerase chain reaction (qPCR) and western blot analysis, we found that the mRNA and protein expression levels of two members of PRC2 were decreased during ATRA-induced HL-60 differentiation, respectively. When treated with ATRA for 72 h, the EZH2 and SUZ12 mRNA levels were decreased to 35% and 38% of the control group, respectively. At the same time, the granulocytic mature surface marker CD11b expression was increased significantly at mRNA level detected by qPCR and protein level detected by flow cytometry. By using chromatin immunoprecipitation assay, we compared the local changes in SUZ12 binding and PRC2-mediated H3K27me3 at the promoter of CD11b during ATRA-induced HL-60 differentiation. Both the levels of SUZ12 binding and PRC2-mediated H3K27me3 at the promoter of CD11b were decreased for 4.1 and 3.8 folds, respectively. And we also found the increase in the acH4 level up to 4 folds after 72 h of ATRA treatment. These results suggested that the histone modification including PRC2-mediated repressive histone marker H3K27me3 and active histone marker acH4 may involve in CD11b transcription during HL-60 leukemia cells reprogramming to terminal differentiation.

  Y.-H. Zhao , D.-P. Wang , L.-L. Zhang , F. Zhang , D.-M. Wang and W.-Y. Zhang
  Aims We used microarray as well as quantitative real-time PCR (Q-RT-PCR) validation to define the genes and/or pathways that are involved in gestational diabetes mellitus (GDM) in patients of Chinese ethnicity. Methods We used the Illumina microarray platform to obtain comprehensive gene expression profiles of blood and placenta taken from GDM-positive and GDM-negative women. Results We found 5197 genes in blood and 243 genes in placenta, which had significantly altered expression profiles attributable to GDM. Genes previously known to have altered expressions as a result of GDM (such as TNF, IL1B, LEP, IFNG and HLA-G) were also validated. In addition, we identified a number of previously unreported genes: VAV3, PTPN6, CD48 and IL15, which had expression patterns that were significantly different from our GDM and control samples, as determined by both microarray and Q-RT-PCR assays. Two significant pathways were identified as GDM-associated pathways through integrated functional annotation. These pathways were: ‘Natural killer cell mediated cytotoxicity’ in blood and ‘Cytokine-cytokine receptor interaction’ in placenta. Furthermore, despite differences between blood and placenta in terms of the quantity of gene expression, we nonetheless observed similar functional distributions in both tissues in terms of immune-related genes. Conclusions These newly identified key genes and pathways may provide valuable information about the pathogenesis of GDM and can be used to improve early diagnosis, prevention, medication design and clinical treatment.
  F. Zhang , L. Dong , C. P. Zhang , B. Li , J. Wen , W. Gao , S. Sun , F. Lv , H. Tian , J. Tuomilehto , L. Qi , C. L. Zhang , Z. Yu , X. Yang and G. Hu
  Aims  To investigate the trend in the prevalence of gestational diabetes mellitus during 1999-2008 in women living in urban Tianjin, China.

Methods  A universal screening for gestational diabetes mellitus has become an integral part of the antenatal care in Tianjin, China from 1998. A total of 105 473 pregnant women living in the six urban districts of Tianjin, China, participated in the gestational diabetes mellitus screening programme between December 1998 and December 2008. The screening test consisted of a 50-g 1-h glucose test. Women who had a glucose reading ≥ 7.8 mmol/l at the initial screening were invited to undergo the standard 2-h oral glucose tolerance test with a 75-g glucose load. Gestational diabetes mellitus was confirmed using the World Health Organization's diagnostic criteria.

Results  The adjusted prevalence of gestational diabetes mellitus increased by 2.8 times during 1999-2008, from 2.4 to 6.8% (P < 0.0001 for linear trend). In 2008, the age-specific prevalence of gestational diabetes mellitus was the highest among women aged 30-34 years (11.3%) and lowest among women aged 25 and under (1.2%). In women aged 35 years and more, the prevalence was 5.3%.

Conclusions  The prevalence of gestational diabetes mellitus has markedly been increasing in a universally screened urban Chinese female population and has become an important public health problem in China.

  W. Yu , F. Zhang , W. Hu , R. Zhang , C. Wang , J. Lu , F. Jiang , S. Tang , D. Peng , M. Chen , Y. Bao , K. Xiang , C. Hu and W. Jia


There is a close link between electrocardiographic ventricular repolarization QT parameters and Type 2 diabetes. The aim of the present study was to assess the effects of QT-related and diabetes-related variants in KCNQ1 on QT interval in a Chinese population.


We recruited 2415 patients with Type 2 diabetes and 1163 subjects with normal glucose regulation in the present study. QT interval was obtained and the heart rate-corrected QT interval (QTc) was calculated using Bazett's formula. Four single nucleotide polymorphisms in KCNQ1 were selected (rs12296050, rs12576239, rs2237892 and rs2237895) and genotyped.


 In participants with normal glucose regulation, the minor allele T of rs12296050 was associated with a 3.46-ms QTc prolongation under an additive model (P = 0.0109, empirical P = 0.0498). In patients with Type 2 diabetes, we did not find any association for the single nucleotide polymorphisms.


Our findings indicate that KCNQ1 is associated with QT interval in a Chinese population with normal glucose regulation.

  Qing-hua Zheng , S. Jiang , F. Zhang , T. Peng and C. Chen
  In this study, we propose a low-delay ALM protocol named TapMulti on Tapestry to achieve scalability and low-delay, . In TapMulti protocol, a delivery tree is designed to reduce end-to-end delay and improve stability of multicast system. This low-delay delivery tree is constructed on Tapestry and it can guarantee a tradeoff between delay and network-traffic load of multicast system by constraining width (maximal out-degree of node in the delivery tree) and depth of the delivery tree. Moreover, the efficient and proportional route mechanism of Tapestry is exploited to decrease the control cost to maintain multicast delivery tree. Simulated results indicate that, compared with other existing ALM approaches on Tapestry, TapMulti is of distinct advantages in aspects of end-to-end delay and control cost.
  J. Han , F. Zhang , L.B. Du , X.H. Han , W.F. Chen and J. Meng
  Increasing pressure to sustain and improve environment has accelerated searching for feed additives with environmental and economic benefits in animal production. This experiment investigated the effect of dietary Biochar Including Vinegar Liquid (BIOV) supplements on weaned pigs growth performance, nutrient digestibility, blood characteristics and fecal noxious gas emission in a 28 days feeding trial. A total of 60 crossbred piglets with an initial BW of 8.07±0.29 kg (28 days of age) were randomly assigned to five dietary treatments with 4 replications per treatment and 3 pigs per pen in a completely randomized design. Dietary treatments included NC (Negative Control; basal diet), PC (Positive Control; basal diet+0.05% oxytetracycline), BV1 (basal diet+1% BIOV), BV2 (basal diet+2% BIOV) and BV3 (basal diet+3% BIOV). Although, PC treatment showed highest Average Daily Gain (ADG) and gain: feed these indices were not found differ with BV1 and BV2 treatments through the 28 days trial (p<0.05). The pigs in BV treatments presented better nitrogen digestibility than PC and NC group (p<0.05) while Dry Matter (DM) and Digestibility Energy (DE) were not affected by BV treatment (p>0.05). Also, the concentration of leucocytes, lymphocyte and IgG were optimal in PC treatment whereas there were no significant differ between antibiotic and BIOV additive (p>0.05). Meanwhile, all the BIOV added treatments decreased BUN and cortisol compared to NC treatment (p<0.05). Moreover, the fecal ammonia, hydrogen sulfide, amine, R.SH and acetic acid gas emissions were decreased, fecal pH was boosted in BV2 and BV3 treatments compared to PC and NC group (p<0.05). Therefore, the results of the present study suggest that BIOV is an animal feed additive with environmental and economic benefits which can be a potential alternative to antibiotics.
  F. Zhang , Y. Zhang , Jun Liu and Hanbin Luo
  Safety culture plays an important role in enterprise safety production. The paper analyzed the factors of real estate enterprise safety culture construction and then designed the questionnaire and did research on real estate enterprise safety culture. The questionnaire consists of workers’ information and seven safety culture dimensions, including safety management system level, publicity and education training level, security issues and management participation level, employee safety consciousness level, staff safety knowledge and skill level, co-workers behavior influence level, as well as responsibility, rewards and pulishment level. Through analyzing the data of the questionnaire and combining it with the safety culture maturity model, the paper concludes that real estate enterprises safety culture is in the second gradient, with the safety culture in a primary stage. Enterprises need to encourage employees to participate in construcing and improving the level of enterprise safety culture. The article puts forward some measures for the improvement of the safety culture construction and some suggestions from the perspective of material, system, spirit and culture.
  C. C . Ginocchio , D. Barth and F. Zhang
  This study compared the clinical performance of the Digene Hybrid Capture 2 (HC2) assay to that of a prototype Third Wave Invader human papillomavirus (HPV) (IHPV) analyte-specific reagent-based assay for the detection of oncogenic or "high-risk" (HR) HPV DNA using liquid-based cytology specimens. In total, 821 ThinPrep vials were tested using both assays. In accordance with the type-specific probes contained within each test, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for the IHPV assay were 95.9%, 97.6%, 97.5%, and 96.1%, respectively, and those for the HC2 assay were 98.1%, 86.2%, 87.1%, and 97.9%. Overall, the sensitivity and NPV were comparable between the assays, but the IHPV assay demonstrated a better specificity and PPV, since the IHPV assay had fewer false-positive HR HPV results. The incorporation of an internal control to evaluate the cellularity of the test material is an important feature of the IHPV assay and should reduce the risk of false-negative results due to insufficient sample collection rather than the lack of HR HPV DNA. An additional benefit of the IHPV assay was the smaller sample volume required (1 ml versus 4 ml for the HC2 assay).
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