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Articles by Ebrahimzadeh Hassan
Total Records ( 2 ) for Ebrahimzadeh Hassan
  Ebrahimzadeh Hassan , Radjabian Tayebeh , Ekhteraei Tousi Samaneh , Bashiri Sadr Zeinalabedin , Niknam Vahid and Zarrei Mehdi
  The present study aims to characterize some Iranian wild species of Valerianaceae with respect to their contents of valerenic acid and its derivatives. Identification of these compounds which are known as reliable markers in Valerianaceae family was achieved using TLC and UV-spectrophotometry methods. Valerenic acid makes substantial contribution to the sedative effect of valerian. Separation of valerenic acid and its derivatives was performed by TLC using a ternary mobile phase of hexane-ethyl acetate-glacial acetic acid (65:35:0.5 v/v) on silica gel HF254+366 plates. Spots were detected at 254 and 366 nm and then revelation of them was carried out with HCl-acetic acid reagent followed by anisaldehyde-sulphuric acid reagent spraying at visible light. Quantitative analysis of valerenic acid and its derivatives was performed using UV-spectrophotometry. The calibration curve of authentic valerenic acid was linear in the range of 2-51 mg L-1. Additionally, for a more accurate determination of total valerenic acid derivatives (including valerenic acid, hydroxyvalerenic acid and acetoxyvalerenic acid) extinction coefficient of each compound in ethanol was used. This is the first report for the identification and quantification of valerenic acid derivatives in all organs of Valeriana sisymbriifolia, Valeriana alliariifolia and Centranthus longiflorus in comparison with those of commercial Valeriana officinalis. Total valerenic acid derivatives content in different organs of these Iranian wild species ranged from 0.06-1.11% (D.W.). Present results showed that Iranian wild species of Valeriana and Centranthus DC. may be used as worthy sources of valerenic acid derivatives.
  Ebrahimzadeh Hassan , Radjabian Tayebeh , Ekhteraei Tousi Samaneh , Niknam Vahid and Mozaffarian Vali-O-Allah
  The aim of the present study was to characterize some Iranian wild species of Valerianaceae with respect to their contents of valepotriates. Identification of these compounds which are known as reliable markers in Valerianaceae family was achieved using TLC and UV-spectrophotometry methods. Valepotriates makes substantial contribution to the sedative effect of valerian. Separation of these compounds was performed by TLC using a ternary mobile phase of toluene-ethyl acetate - methyl ethyl ketone (80:15:5 v/v) on silica gel HF254+366 plates. Separated bands were observed in ultraviolet light at 254 nm. For bands revelation, 2, 4- dinitrophenylhydrazine (DNPH) solution spray was used at visible light. For the quantitative determination of valepotriates a standardized product (Valmane ®) was used to plot two calibration curves. One calibration curve was drawn in the concentration range of 5-156 mg L-1 for determination of valtrate + acevaltrate amounts. The second one was linear in the range of 5-52 mg L-1 for didrovaltrate quantification. The qualitative and quantitative determinations were carried out in all organs of Valeriana sisymbriifolia Vahl, Valeriana alliariifolia Adams and Centranthus longiflorus Stev. (Iranian wild plant species) and commercial Valeriana officinalis L. sample. Results showed that didrovaltrate amounts (dry weight basis) ranged from 0.13% in inflorescence of V. alliariifolia to 3.51% in leaf of C. longiflorus. Also acevaltrate + valtrate contents varied from minimum 0.06% in stem of V. sisymbriifolia to maximum 10.85% in root of V. alliariifolia. Valepotriates contents in these species were compared to those of commercial Valeriana officinalis L. root and rhizome samples (didrovaltrate 1.99-3.23%, valtrate + acevaltrate 5.1-9.26%).
 
 
 
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