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| Articles
by
E.S. Orhue |
Total Records (
2 ) for
E.S. Orhue |
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E.S. Orhue
,
M. Idu
,
J.E. Ataman
and
L.E. Ebite
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This study investigated the possible toxicity of consumption
of the leaf by determining a variety of serum biochemical parameters in
liver and renal function tests, haematological and physical parameters.
A 5 week repeated dose toxicity of Jatropha tanjorensis leave powder
was carried out in rabbits. Forty animals, male and female, were administered
feed mash plus ground J. tanjorensis leaf powder in graded concentrations
of 0, 5, 10 and 25%. All rabbits survived at the end of the study and
results showed no significant alteration in average body weight in the
treatment groups when compared with the control group. The haemoglobin,
hematocrit, platelets and platelet cell distribution width in the female
group, showed significant increase between the control and the treated
groups. This is an indication of an improved bone marrow function. No
severe histopathologic indicator was recorded. |
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A.O. Akhigbe
,
M. Idu
,
E.S. Orhue
,
J.E. Ataman
and
S.O. Ehimwenman
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Toxicological study of Jatropha tanjorensis leaves
was conducted by evaluating changes in weight, biochemical and ultrasonographic
parameters of rabbits that have been administered varying concentrations
(0, 5, 10 and 25%) of the ground leaves mixed with feed-mash for a period
of 30 days. There was no significant difference (p<0.05) in weight
of rabbits. Renal function tests revealed that there was a significant
reduction of serum urea concentration in the male rabbits (p<0.05)
from 38.33 in group C to 18.33 in group D. This suggests that the amount
of J. tanjorensis plant powder used in this study could interfere
positively with the filtration function of the kidney in rabbits. The
ultrasound picture of kidney, heart and spleen showed no significant change
from the control, where as there was reduction in the size of the liver
with increased echogenicity when compared with the control. This may be
an indication of hepatic toxicity. |
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