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Articles by E.O. Ajani
Total Records ( 3 ) for E.O. Ajani
  B.A Salau , A.O. Ketiku , O.L. Adebayo , W.E. Olooto , E.O. Ajani and O. Osilesi
  The involvement of sucrose and its amount in the causation of cardiovascular disease is still controversial and inconclusive. The two latest reports of WHO/FAO and Institute of Medicine of Food and Nutritional Board (IOM of FNB) on optimal level of sucrose consumption are at least contradictory; therefore the need to clarify the effect of different concentrations of sucrose consumption on cardiovascular disease risk factor is expedient. Effect of sucrose consumption was assessed on twenty four male albino rats, four to six weeks old, 48-65 g, divided into five groups: G1 (control), G2 (10% energy supply from sucrose), G3 (20% energy supply from sucrose), G4 (30% energy supply from sucrose). The following parameters were determined: red blood cell count, white blood cell count, packed cell volume, blood and plasma viscosities; fibrinogen level and erythrocyte sedimentation rate. Analyses revealed that inclusion of sucrose at concentration of 20% energy supply significantly increased (p<0.05) blood viscosity by 97.59%, plasma viscosity 16.48%, erythrocyte sedimentation rate 40.00%, plasma fibrinogen13.63% and white blood cell count 6.59%, while no significant effect (p>0.05) was observed on red blood cell count and packed cell volume. The study revealed that consumption of sucrose at twenty percent energy supply increased some selected haematological and haemorrheological parameters associated with cardiovascular disease.
  B.A. Salau and E.O. Ajani
  Alterations in plasma lipid profiles are common occurrences in diabetes. There is also a positive correlation between the risk of developing ischaemic heart disease and raised plasma cholesterol and LDL-cholesterol. Musa sapientum sucker extract has proven to be an effective antidiabetic agent by lowering blood sugar level and improve the islets of Langerhans. In this study, effect of different concentrations of methanolic extracts of Musa sapientum sucker on plasma lipid profile were assessed in alloxan induced diabetic rats. Total plasma cholesterol, HDL cholesterol and triglyceride were determined using enzymatic kits, while plasma LDL cholesterol, VLDL cholesterol, atherogenic and coronary risk indices were calculated. The extract at 5 mg and 10 mg/kg/body weight/day reduced significantly (p<0.05) the total plasma cholesterol, very low density lipoprotein cholesterol and plasma triglyceride. Administration of the extract also reduced significantly (p<0.05) the atherogenic and coronary risk indices. However, a significant increase (p<0.05) was observed in plasma HDL cholesterol. The result of the study indicates that Musa sapientum sucker extract was effective in improving plasma lipid profile associated with cardiovascular risk factors in alloxan induced diabetic rats.
  B.A. Salau , W.E. Olooto , O.L. Adebayo , E.O. Ajani , K.T. Odufuwa and J.O. Olowookere
  Effects of various concentrations of sucrose diet were assessed on thirty weaning male albino rats divided randomly into five equal groups as follows: G1 (baseline group); G2 (control group given rat chow only); G3, G4 and G5 (groups with energy supply from sucrose at 10, 20 and 30%, respectively). The four groups were fed for twelve weeks and then fasted overnight. They were then anaesthetized with diethyl ether and venous blood was collected using cardio puncture method. Plasma was collected by centrifugation and total plasma cholesterol, HDL cholesterol and serum Triglycerides were assayed using Randox enzymatic kit while VLDL cholesterol, LDL cholesterol, Atherogenic index and coronary risk indices were calculated. Sucrose diet increased energy density. It also increased significantly (p<0.05). Plasma total cholesterol, LDL cholesterol, VLDL cholesterol, Triglycerides, Atherogenic and Coronary risk indices while it decreased HDL cholesterol. Present results indicated that sucrose diet at present level of consumption (about 25% energy supply) elevated cardiovascular risk factors in male albino rats and may predispose one to cardiovascular diseases.
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