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Articles by E.N. Obikili
Total Records ( 2 ) for E.N. Obikili
  G.G. Akunna , E.N. Obikili , G.E. Anyanwu and E.A. Esom
  Background and Objective: One of the several side effects of cancer treatment remains cytotoxicity. The curative effect of aqueous zest extract of Citrus paradisi on cisplatin-induced testicular degeneration was studied. Materials and Methods: Sixteen male Wistar rats (10-12 weeks old) weighing 237-276 g were divided into four groups. The first group of rats served as control and were treated orally with 2.5 mL kg–1 b.wt day–1, group B rats treated with single dose of 10 mg kg–1 b.wt., group C and D rats were treated with a single dose of 10 mg kg–1 b.wt. of cisplatin and then treated orally with 10 and 40 mg kg–1 b.wt. of aqueous zest extract of Citrus paradisi for 8 weeks. Results: Results showed a significant (p<0.05) decrease in testis weight, testis volume, sperm count, sperm motility and normal sperm morphology (p<0.01). Also, observed was marked degeneration and atrophied tubules with absence of late stage germ cells evidenced by significant reduction in tubular diameter (p>0.01), perimeter (p>0.01), length (p>0.001) and width (p>0.05) in germinal epithelia height (p>0.05), cross-sectional area, number of profiles per unit area and numerical density, PAS-positive materials and Ki67 cells of seminiferous tubules of the rats treated with cisplatin alone. Interestingly, all these parameters were attenuated in the groups that were post-treated with the extract. Conclusion: Based on these evidenced it was concluded that aqueous zest extract of Citrus paradisi have curative roles in the abatement of cisplatin-induced testicular toxicity in Wistar rats.
  G.G. Akunna , E.N. Obikili , G.E. Anyawu and E.A. Esom
  Background: Spermatogenesis is a complex series of differentiation process that can be interfered by toxic chemicals, heavy metals, heat, radiation, deficiencies of hormones and immunodeficiency. Materials and Methods: Fifteen male Wistar rats (10-12 weeks old) weighing 164-279 g were divided into three groups of four rats each. The rats in group A served as the control group and were treated with 2.5 mL kg–1 b.wt., daily, group B and C rats were given a single dose of 5 and 7 mg kg–1 b.wt., of cadmium chloride solution intraperitoneally. The protocol lasted for 8 weeks. Results: There was a significant (p>0.01) reduction in spermatozoa count, spermatozoa motility, percentage number of morphologically normal spermatozoa and a significant (p>0.01) increase in the percentage number of morphologically abnormal spermatozoa (headless sperm, rudimentary tail, curved tail, curved mid-piece) in animal models exposed to cadmium. There was a significant (p<0.05) difference in SOD, GSH, CAT and MDA activity in the groups of rats when compared to the negative control group. Conclusion: This study has shown that cadmium induces morphological and functional abnormalities on rat spermatozoa by reducing antioxidant status.
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