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Articles by E.M. Al-Olayan
Total Records ( 2 ) for E.M. Al-Olayan
  Sawsan A. Omer , M.A. Elobeid , M.H. Elamin , Z.K. Hassan , P. Virk , M.H. Daghestani , E.M. Al-Olayan , Nadia A. Al-Eisa and Z.M. Almarhoon
  The aim of this study was to evaluate the effect of Olive Leaf Extracts (OLE) on the haematology and biochemistry as well as on the liver and kidney of rats fed on the extracts for 6 weeks. Thirty Wistar albino rats were divided into five groups, Group 1 fed regular diet without OLE (control group), group 2 (fed 0.2% ole), group 3 (fed 0.4% ole), group 4 (fed 0.7% OLE) and group 5 (fed 0.9% OLE) for 6 weeks. Serum concentrations of Alkaline Phosphatase (ALP), Lactate Dehydrogenase (LDH), Total Bilirubin (TBil) and cholesterol, glucose, triglycerides as well as hematological profiles were determined in the present study for each group of rats. There was a significant increase in the serum levels of ALP and total bilirubin in groups 3 and 4 and 5 compared to the control group. There was also significant decrease in the serum triglyceride, glucose and cholesterol in test groups as compared to the control group. The haematological profile showed significant decrease in the values of red blood cell counts, haemoglobin and packed cell volume of the animals in group 5. Microscopically both liver and kidneys showed histological alterations in the form of fatty cytoplasmic vacuolation, necrosis of the hepatocytes and a slight hemorrhage was recorded in the kidneys of the experimental animals especially those fed 0.9% olive leaf extract. The olive leaves extract should be handled with care in arts and other animals and special attention should be paid when using OLE for longer periods of time and at higher doses as it may result in an undesirable effect on liver and kidneys as it has been shown in the present study.
  A.M. Ahmed , E.M. Al-Olayan and M.A. Amoudy
  Great efforts are currently being done to utilize the immune system of mosquito vectors in the battle against the different mosquito-borne parasitic and viral diseases. Based on this control strategy, the current study has been conducted to induce and enhance the most effective immune responses, the humoral and melanization responses, in the dengue fever vector, Aedes aegypti against live bacteria and non-biological agents at 24 h post-treatments. The humoral activity against Bacillus subtilis and Escherichia coli was investigated after thoracic injection of the same bacteria or the lipopolysaccharide (LPS) into mosquitoes using the inhibition zone assay. Melanization response was tested against the thoracic inoculated Sephadex® beads, positively charged CM A-25, negatively charged CM G-25 and neutral CM C-25 and inert glass beads. These immune responses were then enhanced via the oral administration of 0.3% thymoquenone (Thq), the main active ingredient of the black seeds, Nigella sativa, to mosquitoes. Data demonstrated that, on one hand mosquitoes exhibited strong humoral activity against the injected bacteria as well as against the well-known immune sensitive bacteria, Micrococcus luteus. Moreover, melanization response was strong against differently charged Sephadex® beads, but not against the inert glass beads. On the other hand, significant increases in the humoral anti-bacterial lyses activity and anti-beads melanization response (up to 6 folds in some cases) was clearly shown when mosquitoes were maintained on 0.3% Thq-glucose mixture (in 10% glucose). Therefore, these data may indicate that both humoral antimicrobial activity and melanization response could be enhanced to be more effective against disease-organisms transmitted by mosquitoes. Thus, this study suggests a possible immuno-control strategy in the battle against mosquito-born diseases which, in fact, will be tested against dengue viruses in the future studies.
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