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Articles by E.K.I. Omogbai
Total Records ( 4 ) for E.K.I. Omogbai
  E.E. Bafor , M. Nwiko , E.K.I. Omogbai , R.I. Ozolua and Z.A.M. Nworgu
  The effect of the aqueous stem-bark extract of Ficus exasperata (ASE) was studied on oxytocin- and acetylcholine-induced uterine contractions in uterine preparations isolated from non-pregnant Sprague-Dawley rats in oestrus. Preliminary phytochemical analysis was also performed. There were no statistically significant increases in the concentrations of oxytocin and acetylcholine required to elicit 30 and 50% of maximum response (EC30 and EC50, respectively) in the presence of the extract. Salbutamol and atropine, however, significantly inhibited the effects of oxytocin and acetylcholine, respectively. Phytochemical analysis revealed the presence of alkaloids, tannins and saponin glycosides. These results indicate that ASE possesses no inhibitory effect on the non-pregnant rat uterus as claimed by traditional healers.
  M. Idu , O. Timothy , E.K.I. Omogbai and F. Amaechina
  The hypotensive and acute toxicity activities of methanol extract of B. axillaris leaves, obtained by soxhlet extraction, were analyzed using animal models. The extract exhibited a dose-dependent reduction in rabbit blood pressure. Basal mean arterial pressure of 115.67 ± 3.60 mm Hg was progressively reduced to 106.22 ± 3.13 and 69.3 ± 2.59 mm Hg by 2.5 and 20 mg kg-1 doses of extract, respectively. Hematological parameters in Wister rats treated with 1, 2 and 4 g kg-1 of extract showed no significant difference, p>0.05. However, lethal dosage was obtained at 8 g kg-1. The need for further evaluation and prospect of the plant in health care was also discussed.
  G.B.S. Iyalomhe , E.K.I. Omogbai and R.I. Ozolua
  The objective of this prospective, randomised, open, single-centre study was, therefore, to determine the antihypertensive and biochemical effects of 25 mg oral hydrochlorothiazide and 40 mg oral furosemide given once daily for 21 days to 40 patients with mild to moderate uncomplicated essential hypertension aged between 32 and 80 years and 40 age and sex-matched normotensive controls while on their usual diet. Urine volume, systolic and diastolic BP evaluated as Mean Arterial Pressure (MAP) as well as urine and serum sodium (Na+), potassium (K+) and chloride (Cl) were assessed before and during treatment. Both drugs significantly increased diuresis (p< 0.0001); lowered MAP (p< 0.0001) and increased urine K+ (p< 0.001) in the hypertensive subjects compared to controls. It is concluded that once daily 25 mg of hydrochlorothiazide and 40 mg of furosemide are effective in lowering BP as monotheraphy in Nigerians with mild to moderate hypertension and they are associated with some adverse biochemical effects including K+ depletion.
  M. Idu , E.K.I. Omogbai , G.E. Aghimien , F. Amaechina , O. Timothy and S.E. Omonigho
  The phytochemical analysis on stems of Stachytarpheta jamaicensis proved the presence of secondary metabolites, including; tannins, saponins and flavonoids Crude concentrations of aqueous extract of stem showed antimicrobial activity on Bacillus subtilis, Escherichia coli, Candida albicans, Staphylococcus aureus, Pseudomonas aureginosa and slight activity on Proteus vulgaris while the alcoholic extract had almost similar activity, but lesser activity was observed on Escherichia coli.
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