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Articles by E. Muleya
Total Records ( 2 ) for E. Muleya
  F. Mtunzi , E. Muleya , J. Modise , A. Sipamla and E. Dikio
  Trace metals in eight different plants commonly available in South Africa, Kwazulu-Natal Province namely Gunnera perpensa, Pentanisia prunelloides, Carissa bispinosa, Ledebouria revoluta, Pomaria sandersonii, Eucomis autumnalis, Alepidea amatymbica, Artemisia afra and Berkheya setifera have been quantitatively analyzed using Atomic Absorption spectrophotometer. Medicinal plants were disinfected with 0.1% HgCl2 and digested with 95% H2SO4 and 35% H2O2. Six heavy metals (Fe, Cu, Mn, Pb, Ni, Zn) were chosen on the basis of their effects on human health. From the results of the study, all six heavy metals were present in all the plants, except that Pb was not detected in six of the plants. The highest level of Fe was observed in Gunnera perpensa at 1.12±0.003 ppm whilst the lowest level was found in Alepidea amatymbica at 0.0001±0.00 ppm±0.0005. The concentrations of Mn, Pb, Ni and Zn were all less than 1.5 ppm and the lead concentration in the water extract of Berkheya setifera was found to be high at 5.74±0.110 ppm but still falls below permissible limit of 10 ppm. The concentration of Cu was found to be 1.36±0.0021 ppm in Pomaria sandersonii and lowest in Gunnera perpensa at 1.24±0.002 ppm. The findings generally suggest that the use of these plant species for controlling diseases will not cause heavy metal toxicity and can be of good use to the users in cases of micronutrient deficiency.
  E. Muleya , A.S. Ahmed , A.M. Sipamla and F.M. Mtunzi
  Ledebouria revoluta, Berkheya setifera and Carissa bispinosa are some of the medicinal plants used in South African traditional medicine. An investigation to evaluate antimicrobial, anti-inflammatory and free radical scavenging activities of the root crude extracts and fractions from the three plants was carried out. Reduction by 2, 2-azinobis (3-ethylbenzothiazoline)-6-sulfonic acid (ABTS.+) and 2, 2-di (4-tert-octylphenyl)-1-picrylhydrazyl (DPPH.) radicals were used to assess antioxidant capacities by change in absorbance in a UV-VIS spectrophotometer. Anti-inflammatory activity of the plant extracts against 15-soybean derived lipoxygenase (15-LOX) enzyme was evaluated as increase in absorbance at 234 nm after addition of soya bean derived 15-LOX, using linoleic acid (134 µM) as substrate. Anti-microbial activities were determined by assessing the plant samples’Minimum Inhibitory Concentrations (MICs) by a micro dilution method. Carissa bispinosa and Berkheya setifera have shown good to moderate antimicrobial activity. Ledebouria revoluta displayed good activities (20 µg/mL) for both acetone and methanol fractions against E. coli and good-moderate activity (160-320 µg/mL) against the rest of the bacterial strains used. Anti-fungal activity for Ledebouria revoluta methanol fraction (20 µg/mL) is high against Candida albicans. Percentage inhibition of 15-soybean lipoxygenase enzyme by the crude extracts at concentration of 25 µg/mL was for Berkheya setifera, 80%, Carissa bispinosa, 65% and Ledebouria revoluta, 40%.
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