Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by Dimo Theophile
Total Records ( 3 ) for Dimo Theophile
  Bella Ndzana Martin Thierry , Tsala David Emery , Ngo Lemba Tom Esther , Aboubakar Oumarou Bibi Farouck , Bilanda Danielle Claude and Dimo Theophile
  The stem bark of Tetrapleura tetraptera (Taub) [Mimosaceae] is used in cameroonian ethnomedicine for the treatment of hypertension and diabetes. This experiment was conducted to evaluate the possible effects of Tetrapleura tetraptera Aqueous Extract (TAQE) against hypertension and investigate its antioxidant effect in salt-induced hypertensive rats. High-salt hypertensive rats (9%) received vehicle (distilled water, 10 mL/kg/day), TAQE (100 or 200 mg/kg/day) or captopril 20 mg/kg/day. After a period of 4 weeks, Systolic Blood Pressure (SBP) was measured by invasive method. The lipid profile, oxidative status and liver function were evaluated by colorimetric method. There were significant rise in SBP and heart rate in salt treated rats. The malondialdehyde and antioxidative enzymes (catalase and superoxyde dismutase) levels were significantly elevated and decreased respectively in high salt as compared to control. The oral co-administration of TAQE with high salt reduced the SBP and improved the antioxidant status, lipid profile and liver function. Captopril associated with high salt prevented the some alterations induced by salt consumption in rats. This study supports the traditional used of Tetrapleura tetraptera against hypertension. Tetrapleura tetraptera could prevent the rise in blood pressure and improved the oxidative status in salt model of hypertension.
  Bella Ndzana Martin Thierry , Ngo Lemba Tom Esther , Aboubakar Oumarou Bibi Farouck , Tsala David Emery and Dimo Theophile
  Background: Tetrapleura tetraptera (Schumach and Thonn) Taub stem bark is used in African folk medicine to treat hypertension. In the present study, the antihyperlipidemic and antioxidant effects of Tetrapleura tetraptera aqueous extract was investigated in high salt-sucrose-induced hypertensive rats. Methods: Hypertensive rats were obtained from normotensive Wistar rats by giving daily, 2 mL/100 g salt solution (9%) p.o., with free access to sucrose solution (10%) as drinking water. Another set of rats were divided into three groups of five rats each and treated respectively with salt-sucrose and the aqueous extract of Tetrapleura tetraptera (100 and 200 mg kg-1) or captopril (20 mg kg-1). The effects of plant extract were evaluated after 3 weeks on blood pressure, lipid profile, oxidative status and liver function of animals and compared to those of normotensive control rats. Blood pressure was evaluated by invasive method and biochemical parameters were evaluated by colorimetric and kinetic methods. Results: Chronic salt-sucrose consumption increased systolic arterial blood pressure (30.05%) and heart rate (15.36%) as compared to control. Tetrapleura tetraptera aqueous extract (100 and 200 mg kg-1) or captopril significantly prevented the increase in blood pressure and heart rate and inhibited salt-sucrose-induced lipid peroxidation in the liver. Tetrapleura tetraptera countered salt-sucrose induced oxidative stress by enhancing the activity of antioxidant enzymes (catalase, superoxide dismutase) and glutathione content. The plant extract significantly reduced the high concentration of serum Total Cholesterol (TC), glucose, triglyceride (TG) and low density lipoprotein (LDL-C) and increased high density lipoprotein (HDL-C) observed in salt-sucrose hypertensive rats. Tetrapleura tetraptera also prevented the increase in atherogenic index. Conclusions: these finding supports the traditional use of Tetrapleura tetraptera extract and suggested that the bark of this plant could protect from salt-sucrose damage by enhancing activities of enzymes and holding up the increase of lipid markers and membrane peroxidation.
  Ngoungoure Madeleine Chantal , Bilanda Danielle Claude , Dzeufiet Djomeni Paul Desire , Mballa Marguerite Francine , Mengue Ngadena Yolande Sandrine , Kameni Poumeni Mireille , Mbolang Nguegang Lohik , Dimo Theophile and Kamtchouing Pierre
  Background and Objective: Anthocleista schweinfurthii is used traditionally to manage female infertility and menopausal complaints. This study aimed to evaluate oral acute toxicity and potential estrogenicity of aqueous extract of Anthocleista schweinfurthii in ovariectomized rats. Materials and Methods: The acute toxicity was evaluated by administration of the extract at unique dose of 2000 mg kg–1. For estrogenic-like activity, thirty animals were sham-operated or ovariectomized. After 84 days of surgery, six groups of five rats each were daily treated orally during 28 days with: Distilled water for group 1 (sham-operated) and group 2 (ovariectomized), estradiol valerate (group 3) and the 3 doses of extracts [groups 4, 5 and 6 (ovariectomized)]. Evaluation of weight focused on uterus and aorta, biochemical evaluation focused on serum and aorta supernatant and histological evaluation focused on vagina and uterus. Data were assessed using one-way analysis of variance (ANOVA) and post hoc Tukey’s test. Results: No behavioral abnormality was observed in rats treated with extract in comparison with normal animal. In relation to sham-operated control, ovariectomy induced dystrophy of vagina and uterine, a significant increase of aorta wet weight, total cholesterol, triglycerides, LDL-cholesterol and malondialdehyde levels (in aorta) as well as an important decrease of HDL-cholesterol and nitrites levels (in aorta). Treatment with plant extract as well with estradiol induced differentiation of vaginal cornification in ovariectomized rats and increased vaginal epithelial cell, height of vagina and uterine epithelia. Furthermore, Anthocleista schweinfurthii improved lipid profile and oxidative stress status in aorta. Conclusion: Anthocleista schweinfurthii had low toxicity and shown estrogenic activity in ovariectomized rats by reducing certain post-menopausal symptoms.
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility