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Articles by Daryoush Mohajeri
Total Records ( 2 ) for Daryoush Mohajeri
  Ali Rezaie , Ghafour Mousavi , Daryoush Mohajeri and Gholamreza Asadnasab
  Percutaneous needle biopsy of the kidney may be helpful in formulating prognoses and treatment plans for some disease of kidney. Ultrasound guidance for renal biopsy improves the efficacy of the procedure. Complications of renal biopsy include hematuria, hemorrhage, infection, local peritonitis and severe circulatory dysfunction. The purpose of this study was to evaluate the accuracy of the technique and the possible complications of biochemical, hematological, radiological, ultrasonographical and pathological changes after ultrasound-guided needle biopsy of the kidney. Ten adult dogs were used, an 18 gauge Vim Tru Cut biopsy needle was introduced into the cranial pole of the right kidney using sonographic guidance. Clinical, ultrasonography and radiology, hemathological, biochemical and pathological changes were evaluated after biopsy procedure. All the biopsy samples contained renal tissue. Clinical evaluations showed that changes were all within normal reference ranges. Ultrasonographically and radiologicallly evaluations showed that no changes in kidney sizes. The results of hematological and biochemical evaluations showed that no statistically significant difference (p>0.05) between blood samples performed pre-biopsy and post-biopsy was found during the study. The results of this study indicate that the ultrasound-guided renal biopsy can be safely obtained from healthy dogs using 18-gauge Vim Tru Cut biopsy needle. Our study suggests that ultrasound-guided renal needle biopsy procedure has a minimal complication in dogs.
  Daryoush Mohajeri , Bahram Amouoghli Tabrizi , Ghafour Mousavi and Mehran Mesgari
  This research was performed to characterize the hypoglycemic and pancreas-protective effect of ethanolic extract of Crocus sativus L. stigma in alloxanized diabetic rats. The ethanolic extract of Crocus sativus L. stigma was administered orally and intraperitoneally at different doses (20, 40 and 80 mg kg 1) to normal rats. The dose of 40 mg kg 1 was found to be more effective dose in IP route and it decreases Blood Glucose Level (BGL) by 33.9% in normal healthy rats after 6 h of administration. Although, oral route of C. sativus L. also caused significant reductions of blood glucose levels in healthy rats, the effect was minor. The extract administered by IP route at this dose showed an acute hypoglycemic effect in mild and severely alloxan-diabetic rats. Treatment of mild (FBG 120-250 mg dL 1) and severely (FBG 250-300 mg dL 1) diabetic rats for 14 days with the more effective dose (40 mg kg 1) reduces the fasting blood glucose by 41.4% in Mild Diabetic (MD) and 30.7% in Severely Diabetic (SD) rats. After daily treatment with the same dose (40 mg kg 1) of ethanolic saffron extract for 14 days to normal as well as MD and SD rats, the plasma insulin levels were assayed. Serum insulin level showed significant increase in diabetic rats (33.3% MD, 27.3% SD). The histopathological studies of pancreas in ethanolic extract treated diabetic groups showed a reversed damage caused by alloxan to the pancreatic islets as almost normal appearance. The findings of our study indicate the hypoglycemic and potential antihyperglycemic nature of the extract, helping in regeneration of damaged pancreas in experimental dibetes.
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