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Articles by D.P. Oparinde
Total Records ( 2 ) for D.P. Oparinde
  A.S. Atiba , A.O. Olawuyi , J.O. Akande , T.A. Niran-Atiba , NO Bello and D.P. Oparinde
  Background and Objectives: Dyslipidemia and free radical injury are important risk factors in the pathogenesis of stroke. The observations of various researchers on the association between the parameters of lipid profile and malondialdehyde (product of free radical injury) level in patients with stroke are still inconclusive. This study estimated the plasma concentration of Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein-Cholesterol (LDL-Chol), High Density Lipoprotein-Cholesterol (HDL-Chol) and serum level of malondialdehyde (MDA) in patients with stroke. Materials and Methods: A total of 60 patients with stroke, 40 age and sex-matched volunteers were recruited after obtaining their informed consent. Plasma and serum were extracted from whole blood collected from each subject and control. The serum MDA as well as plasma TC, TG, LDL-Chol and HDL-Chol were determined by various methods in the laboratory. Results: The mean values of MDA (11.02 vs. 7.82 nmol mL1), TG (1.61 vs. 0.84 mmol L1) and LDL-Chol (2.74 vs. 2.06 mmol L1) were significantly higher in patients with stroke than the controls (p<0.001). The mean value of HDL-Chol was significantly lower in stroke patients (1.10 mmol L1) than the controls (1.60 mmol L1) (p<0.001). However, no significant difference was observed between the mean TC in stroke patients and controls (4.37 vs. 4.16 mmol L1, p = 0.215). Total cholesterol has a significant positive correlation with LDL-Chol (r = 0.757, p<0.01) and MDA (r = 0.258, p = 0.047) whereas, it has significant negative correlation with HDL-Chol (r = -0.316, p = 0.014). Conclusion: Stroke is shown to be associated with free radical injury as a result of increased serum MDA. Significant positive correlation between MDA and Total Cholesterol (TC) further explains the link between free radical injury and dyslipidaemia in stroke patients.
  E.O. Akanni , V.O. Mabayoje , T.O. Zakariyahu and D.P. Oparinde
  Alcohol abuse is fast becoming a public health concern among the Nigerian youths and adults strata of the society. A study on the effects of heavy alcohol consumption on haematological parameters was conducted on 130 subjects, comprising of 46 non-alcohol consumers who served as controls and 84 heavy alcohol consumers to determine the possible haematological attendant risks of the social behavior. Their ages ranged between 18-60 years. Sysmex KX-2IN instrument was used to determine the haematological parameters such as PCV, Haemoglobin, Red blood cell, Platelets, White blood cells total and differential counts of neutrophil and lymphocytes automatically. The result shows a significant difference (p<0.05) in the values obtained for alcohol drinkers which are high compared to that of the control group which could be dehydration based haemoconcentration. This study showed that abstinence from alcohol consumption had no effects on haematological parameters while its heavy consumption has deleterious effects such as severe infections to consequences of bone marrow malfunctioning. Hence clinical history of alcoholism during haematological investigations could be helpful and recommended.
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