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Articles by D. Liang
Total Records ( 4 ) for D. Liang
  J Yang , X Liu , J Yu , L Sheng , Y Shi , Z Li , Y Hu , J Xue , L Wu , Y Liang , J Xia and D. Liang

Gene therapy has emerged as a promising approach for the lethal disorder of Duchenne muscular dystrophy (DMD). Using a novel non-viral delivery system, the human ribosomal DNA (hrDNA) targeting vector, we targeted a minidystrophin-GFP fusion gene into the hrDNA locus of HT1080 cells with a high site-specific integrated efficiency of 10–5, in which the transgene could express efficiently and continuously. The minidystrophin-GFP fusion protein was easily found to localize on the plasma membrane of HT1080 cells, indicating its possible physiologic performance. Our findings showed that the hrDNA-targeting vector might be highly useful for DMD gene therapy study.

  D. Liang , W.Q. Xue and M.G. Peng
  The process of changing the channel associated with the current connection while a call is in progress is under consideration. The estimation of call dropping probability in handover process of a one dimensional traffic system in 3GPP LTE is discussed. The analytical probability of call dropping is deduced and then estimated by Monte Carlo simulation. As the call dropping probability is always very small, it can be considered as rare event. To reduce the sample size of simulation, importance sampling is used by increasing the probability of average coming rate for handover traffic and decreasing the probability of available channels. The simulation results suggest the sample size can be tremendously reduced by using importance sampling.
  X.H. Chen , L. Niu , Y.J. Zhou , Z. Bi , G. Ding and D. Liang
  Affinity propagation is an algorithm which is proposed in recent years. It is an algorithm of broad application and high accuracy. From the perspective of statistic, the clustering error falls into two major categories. One results from environmental distraction, which belongs to a random error. Another part is system error resulting from the shortcoming of the fingerprint-based location technique. We refine this shortcoming as aliasing. Aliasing means that there are several distinct locations but having the same RSS vector. When there are clusters having the same vector as a certain input RSS vector, fingerprint-based technique is not able to indicate which cluster is the correct one. So, how to avoid aliasing error has become a crucial problem to solve. In this study, we proposed an innovative approach inspired by Affinity Propagation and based upon the log-normal shadowing model. The experimental results demonstrate that this approach not only achieves lower location error and quicker coverage speed, but also avoid great error to some extent.
  F. Crucenau , D. Liang , R. L. Leheny and G. S. Iannacchione
  A high-resolution calorimetric study of the specific heat (Cp ) has been carried out for the isotropic to nematic phase transition in an aligned liquid crystal (octylcyanobiphenyl - 8CB) and aerosil nano-colloid gel. A stable alignment was achieved by repeated thermal cycling of the samples in the presence of a strong uniform magnetic field, which introduces anisotropy to the quenched random disorder of the silica gel. In general, the specific heat features of the I-N transition in aligned (anisotropic) gel samples are consistent with those seen in random (isotropic) gel samples, namely the observance of two Cp peaks and non-monotonic transition temperature shifts with increasing silica concentration. However, larger transition temperature shifts with silica density, modification of the phase conversion process in the two-phase coexistence region, and a larger effective transition enthalpy are observed for the aligned samples. The lower-temperature aligned Cp peak is larger and broader while exhibiting less dispersion than the equivalent peak for the random gel. This may be a consequence of the alignment altering the evolution from random-dilution-dominated to random-field-dominated effects. The exact origin of the larger transition temperature shifts is uncertain but the larger enthalpy suggests that the nematic state is different in the aligned system than in random gels. The general non-monotonic behaviour of the transition temperature is interpreted using dimensional analysis as a combination of an effective elastic stiffening of the liquid crystal combined with a liquid crystal and aerosil surface interaction energy.
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