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Articles by Chiu-Lan Hsieh
Total Records ( 3 ) for Chiu-Lan Hsieh
  Kuan-Chou Chen , Chao-Ming Chuang , Li-Yun Lin , Wen-Ta Chiu , Hui-Er Wang , Chiu-Lan Hsieh , Tsuimin Tsai and Robert Y. Peng
  Guava [Psidium guajava L. (Myrtaceae)] budding leaf extract (PE) has shown tremendous bioactivities. Previously, we found seven major compounds in PE, i.e., gallic acid, catechin, epicatechin, rutin, quercetin, naringenin, and kaempferol. PE showed a potentially active antiglycative effect in an LDL (low density lipoprotein) mimic biomodel, which can be attributed to its large content of polyphenolics. The glycation and antiglycative reactions showed characteristic distinct four-phase kinetic patterns. In the presence of PE, the kinetic coefficients were 0.000438, 0.000060, 0.000, and −0.0001354 ABS-mL/mg-min, respectively, for phases 1 to 4. Computer simulation evidenced the dose-dependent inhibition model. Conclusively, PE contains a large amount of polyphenolics, whose antiglycative bioactivity fits the inhibition model.
  Ming-Hua Yang , Chao-Ming Chuang , Chiu-Lan Hsieh , Hui-Er Wang , Kuan-Chou Chen , Wen-Ta Chiu , Chun-Ming Shih and Robert Y. Peng
  To find in vivo behaviors of an antioxidant when used as an adjuvant cancer therapy, a more detailed integrated pharmacokinetic scheme is needed. Major reaction parameters associated with the sequential routes from ingestion to decay of an antioxidant were used in mathematical analysis, which included absorption rate coefficient ka, quenching rate coefficient of the antioxidant kq1 and tissue quenching rate coefficient kr. The model was then treated with computer simulation using cited decay rate coefficients and some assumed parameters. When intestinal absorption rate coefficient ka becomes larger, retention time of antioxidant in plasma would be prolonged. moreover, ka had no effect on either quenching ability of antioxidants or tissue recovering capability. in quenching plasma ROS, the larger the quenching coefficient kq1, the shorter peak- and the life-times would be for the secondary free radicals that are formed in primary quenching. Conclusively, it is suggestive to prescribe an antioxidant therapy with an appropriate values of ka and larger values of kq1.
  Chia-Hung Liu , Chiung-Chi Peng , Chiung-Huei Peng , Chiu-Lan Hsieh , Kuan-Chou Chen and Robert Y. Peng
  Diabetes Mellitus (DM) related Advanced Glycation End products (AGEs) are considered to induce functional impairment of cavernosal smooth muscle relaxation and cause Erectile Dysfunction (ED). We used rats to examine the in vitro effects of Psidium guajava L. (Myrtaceae) budding leaf extract (PE) on pharmacological relaxation of corpus cavernosum smooth muscle strips obtained from diabetic rats. After 8 weeks, the mean glycosylated haemoglobin (HbA1c), serum cholesterol and triglyceride concentrations were significantly higher in the non-PE diabetic than in the age-matched control animals. Interestingly, in diabetic animals fed PE, serum cholesterol and triglyceride levels were significantly lower than in their peers given a standard diet. The administration of PE to diabetic animals for 8 weeks reversed the expected impaired relaxation response and nitric oxide production in cavernosal smooth muscle exposed to acetylcholine or electrical field stimulation. The administration of PE to rats with 8 weeks of uncontrolled diabetes reverses DM-induced harmful effects on vascular smooth muscle.
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