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Articles by C.O. Esimone
Total Records ( 4 ) for C.O. Esimone
  C.O. Esimone , P.U. Onuh , N.C. Obitte , M.K. Egege and K.C. Ugoeze
  The aim of this research was to formulate Zapoteca portoricensis root extract as Lozenges and to evaluate some of their antimicrobial and tablet properties. The root extracts were formulated into Lozenges using either Sodium Carboxy Methyl Cellulose (SCMC) or Carboxy Methyl Cellulose (CMC) as binders. Uniformity of weight, crushing strength, microbial sensitivity and pre-extinction time studies (using E. coli, S. aureus and Candida albicans) were conducted on three Lozenges formulated with either SCMC (Batch A), CMC (Batch B) and a reference standard, DequadinR, containing dequalinium hydrochloride (Batch C). Results showed that Batches B and C passed the weight uniformity test. The three batches had mean crushing strengths of 4.86±0.043, 3.9±0.03 and 13.1±0.43 KgF, respectively for A, B and C. S. aureus and Candida albicans were sensitive to the test lozenges whereas Escherichia coli was not. Candida albicans was minimally sensitive to the standard lozenge, while S. aureus was not. Both the test and the standard samples showed extinction times greater than 30 min.
  I.R. Iroha , M.U. Adikwu , E.S. Amadi , I. Aibinu and C.O. Esimone
  Clinical isolates of Escherichia coli (No. = 109) were collected from Microbiology Laboratory unit of a tertiary hospital (Ebonyi State University teaching hospital, Abakaliki, EBSUTH) and a secondary hospital (Federal Medical Center, Abakaliki, FMC) from four different clinical specimens (urine, stool, blood and sputum) between February to November 2006. Sixty-three clinical isolates of E. coli were isolated from EBSUTH while forty-six were from FMC Abakaliki. These organisms were characterized and identified to species level using standard identification technique. Sensitivity studies were carried out on the test organisms using disc diffusion method and later the organisms were characterized phenotypically for ESBL production using the Double Disc Synergy Test (DDST). A preliminary molecular characterization of the ESBL producing isolates were further carried out based on the evaluation of their plasmid profile via agarose gel electrophoresis. The over-all result of the study revealed that the prevalence of ESBL producing organisms was high 18 (16.5%) in our environment. The rate of occurrence varied within the two hospitals with 11 (23.9%) from FMC (urine 2 (18.2%), blood 5 (35.7%), wound 3 (30%) semen 1 (33.3%) and non was isolated from sputum while 7(11.1%) were from EBSUTH (urine 2(9.5%), blood 3 (21.4%), wound 2 (18.2%) respectively and non was isolated from sputum and semen. The plasmid profile studies revealed the presence of low molecular weight plasmid DNA within the ranges of 21.3-29.4 kb.
  I.B. Moses , C.O. Esimone , I.R. Iroha , E.N. Ugbo , A.C. Nwuzo , J.O. Orji , E.A. Nwakaeze , N.B. Agumah , A.A. Emioye , E.G. Ukpai and L.N. Ogene
  Background and Objective: The increase in antibiotic-resistant Staphylococcus pseudintermedius among pets and the transfer of S. pseudintermedius from pets to humans threaten veterinary medicine and public health. The objective of this study was to determine the antibiotic resistance patterns and prevalence of virulence genes among Staphylococcus pseudintermedius isolates obtained from dogs and dog owners in Abakaliki, Nigeria. Materials and Methods: Swab samples from 112 shelter dogs and 97 dog owners were processed using standard microbiological procedures. Antibiotic susceptibility test was done by Kirby Bauer disc diffusion technique. Screening for virulence genes was done by Polymerase Chain Reaction (PCR). Results: Exactly 99 S. pseudintermedius isolates including 52 Methicillin Resistant Staphylococcus pseudintermedius (MRSP) strains were recovered from dogs and humans. Sec, exi, siet and lukD virulence genes were confirmed by PCR. Isolates were highly resistant (69.2-100%) to amoxicillin, cefepime and ceftazidime, but very susceptible (66.3-80.2%) to ofloxacin, doripenem, ertapenem and chloramphenicol. A total of 73 (73.7%), 2 (2%), 62 (62.6%) and 55 (55.6%) isolates harboured sec, exi, siet and lukD virulence genes, respectively. Conclusion: Isolates in this study harboured sec, siet, exi and lukD virulence genes and were also notably more resistant than those reported in literature. There was phenotypic homogeneity in the antibiotic resistance profiles of isolates from both humans and dogs in households that were sampled, thus depicting a possible zoonotic transmission event from dogs to their owners. Hence, monitoring of antimicrobial resistance, appropriate hygienic measures such as; hand washing after attending to dogs should be adopted so as to minimize the spread of resistance and virulence.
  I.R. Iroha , E.S Amadi , J.O. Orji , A.C. Ogabus , A.E. Oji and C.O. Esimone
  The present study evaluated the antimicrobial effect of different combinations of gentamicin and floroquinolones (ciprofloxacin, ofloxacin, perfloxacin and gatifloxacin) against extended spectrum beta lactamase (ESBL) positive E. coli isolates using checkerboard method. One hundred and four clinical isolates of E. coli obtained from urine (26), blood (24), stool (20), sputum (19) and semen (14) were investigated for ESBL production. Fifteen (14.4%) were positive for ESBL production in the following order: 4(3.8%) from urine, 3(2.8%) from blood, 3(2.8%) from stool, 3(2.8%) from sputum and 2(1.9%) from semen. Five representative ESBL positive isolates, one from each specimen, were investigated for their susceptibility patterns to different gentamicin and floroquinolone combinations. The combinations of gentamicin and ciprofloxacin, perfloxacin and gatifloxacin, respectively at different ratios were predominantly synergistic in activity while gentamicin and ofloxacin combinations were primarily indifference in activity. These results may have some therapeutic significance in the management of ESBL infections especially in areas of the world where ESBL organisms are either emerging or re-emerging.
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