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Articles by C. Jothimanivannan
Total Records ( 5 ) for C. Jothimanivannan
  C. Jothimanivannan , R.S. Kumar and N. Subramanian
  The aim of the present study was to evaluate the anti-inflammatory and analgesic activities of the ethanol extract of aerial parts of Justicia gendarussa (EJG) in animal models. The anti-inflammatory activity of the extract was evaluated by using carrageenan-induced rat paw edema and cotton pellet granuloma method. The analgesic activity of the extract was evaluated for its central and peripheral pharmacological actions by using Eddy’s hot plate method and acetic acid-induced writhing, respectively. The study was carried out in two different dose levels of 250 and 500 mg kg-1 orally. The EJG did not produce any mortality up to 2000 mg kg-1. EJG at the dose of 500 mg kg-1 showed maximum inhibition of 52% in carrageenan-induced paw edema and 45% inhibition in dry weight cotton pellet granuloma formation. Dose dependent increase in latency of response in the hot plate method and 33% inhibition in acetic acid induced writhings in mice were observed with EJG at the dose of 500 mg kg-1. The pharmacological screening of the extract showed significant (p<0.001-0.01) dose-dependent anti-inflammatory activity with good analgesic profile when compared with reference standard. The presence of flavonoids might be responsible for these activities and which are probably mediated via inhibition of various autocoids formation and release.
  S. Kameshwaran , C. Jothimanivannan , R. Senthilkumar and A.R. Kothai
  Objective: Tecoma stans (Bignoniaceae) is conventionally used for a variety of treatments and also in the cases of arteriosclerosis and circulatory irregularities. Hence, the present exploration was intended to assess the potential effect of Methanol Extract of flowers of Tecoma stans (METS) on obesity and hyperlipidiemia on Atherogenic diet induced obese rats. Methods: METS at the doses of 100 and 200 mg kg-1 were administered along with atherogenic diet for a period of 42 days. Parameters such as body weight, body temperature, serum lipid profiles, SGOT and SGPT were evaluated. Results: METS at the dose of 200 mg kg-1 significantly (p<0.001) corrected the altered parameters, similar to that of standard drug sibutramine (2 mg kg-1). Conclusion: From the observations of the study performed, it could be predicted that Tecoma stans flower extract exerted significant anti-obese and anti- hyperlipidemic effects in rats fed on Atherogenic diet.
  S. Kameshwaran , A.R. Kothai , C. Jothimanivannan and R. Senthilkumar
  Objective: Tecoma stans is a plant with a diversity of ethnic medicinal uses along with antioxidant activity. Hence, we have intended to screen hepatoprotective activity with ethanolic (EETS) extract of flowers of Tecoma stans. Methods: Powder of flower petals extracted with ethanol and it was subjected for phytochemical screening to categorize the different phytoconstituents. Hepatoprotective activity of the extract was studied against the liver injury induced by paracetamol, carbon tetrachloride, thioacetamide and chronic liver damage induced by carbon tetrachloride in rats. Results: The extract significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. EETS at the dose of 500 mg kg-1, p.o. prevented the increase in liver weight when compared to hepatoxin treated control while the extract at the dose 250 mg kg-1 was ineffective except in the paracetamol induced liver damage. In the chronic liver injury induced by carbon tetrachloride, EEPG at the dose of 500 mg kg-1, p.o. was found to be more effective than the extract at the dose of 250 mg kg-1, p.o.. Histological examination of the liver tissues supported the hepatoprotection. Conclusion: It is concluded that both extracts of flowers of Tecoma stans possesses good hepatoprotective activity.
  S. Kameshwaran , C. Jothimanivannan , R. Senthilkumar , S. Thenmozhi , R. Sundaraganapathy and M. Dhanalakshmi
  Objective: Diarrhea is one of the widespread wellbeing situation upsetting people in less developed countries. This study was done to appraise anti-diarrheal influence of the ethanolic flower extract of Tecoma stans (EETS) using Wistar albino rats to determine the acute toxicity in mice. Material and Methods: The flowers were collected and extracted with 70% ethanol. The dry extract was reconstituted using normal saline for the oral administration to diverse groups of rats at doses of 200, 400 and 600 mg kg-1. Anti-diarrheal activity was resulted using the percentage fall in the incidence of defecation in rats with castor oil-induced diarrhea. Loperamide (1 mg kg-1) was worn as positive control. Acute toxicity was evaluated by fortitude of LD50 and observations of toxic signs. Results: EETS showed momentous (p<0.05) antidiarrheal activity evidenced by the lessening in rate of defecation by up to 78.33% at 600 mg kg-1 b.wt. analogous to loperamide (100%). This activity could be accredited to the phytochemicals such as flavonoids and tannins in Tecoma stans that were present in high levels and have been reported to demonstrate antidiarrheal activity through denaturing protein hence forming protein tannates which curtail the intestinal mucosa permeability. The LD50 of the crude EETS was 10,715 mg kg-1. Conclusion: The findings of this study illustrate that the flower of Tecoma stans have a very significant antidiarrheal commotion and are not dangerous to use as indicated by the high LD50 value. This ropes the conventional use of the EETS as herbal therapy for treatment of diarrhea.
  N. Subramanian , C. Jothimanivannan , R. Senthil Kumar and S. Kameshwaran
  Background: Anxiety is associated with diverse range of psychiatric conditions. Justicia gendarussa Burm. (Acanthaceae) has been traditionally used for the treatment of various ailments such as rheumatism, inflammation, nerve diseases, lumbago and chorea. Despite a long tradition of use, no systematic phytochemical and pharmacological work has been carried out on this potential plant. Objective: Thus, Justicia gendarussa Burm was subjected to preliminary anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic. Materials and method: In the present investigation the aerial parts of plant parts were extracted with ethanol. The plant extract (EJG) at the dose of 250 and 500 mg kg-1 were evaluated for anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic. EJG administered orally in two different doses of 250 and 500 mg kg-1, was able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze, also increases the time spent by mice in the illuminated side of the light-dark test, as well as caused significant reduction in freezing time in comparison with control animals. This effect was comparable to that of the benzodiazepine diazepam at the dose of 2.0 mg kg-1. Conclusion: These results indicate that ethanolic extract of Justicia gendarussa Burm has an effective anti-anxiety effect.
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