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Articles by C. Chow
Total Records ( 1 ) for C. Chow
  G. Ko , W. So , P. Tong , R. Ma , A. Kong , R. Ozaki , C. Chow , C. Cockram and J. Chan
  Aims To develop a simple scoring system for identifying Southern Chinese at risk of diabetes.
Methods The score was derived from a risk factor matching cohort for Type 2 diabetes in Hong Kong Chinese (cohort 1, 2448 subjects without a history of diabetes; age, mean ±  sd 37.2 ± 8.9 years, median 36.0 years; 1649 had risk factors for diabetes and 799 were age-matched control subjects from the community). Two other cohorts were used to validate the risk score (cohort 2, 3734 subjects with risk factors for diabetes; and cohort 3, 1513 participants of a community diabetes survey). All subjects had a 75 g oral glucose tolerance test (OGTT).
Results In cohort 1, 270 (11%) of the subjects were found to have diabetes on OGTT. A risk score system was derived using the β values of the corresponding predictors in the logistic regression analysis. The area under the curve (95% confidence intervals) of the score system was 0.735 (0.705, 0.765). The application of a risk score of ≥ 16 increased the detection rate 2.5–4 times in all three cohorts. A high post-test probability of diabetes of > 60% was derived from a risk score of ≥ 20. Only 10–20 and ∼5% with a score of ≥ 12 and ≥ 16, respectively, are indicated for OGTT. This will considerably improve the yield of OGTT screening.
Conclusions A simple risk score identifies young-to-middle-aged Southern Chinese at high risk for diabetes. Subjects with a score of 16 or above (out of 30) should undergo OGTT for definitive diagnosis of diabetes.
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