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Articles by Bechan Sharma
Total Records ( 5 ) for Bechan Sharma
  Ratnesh Kumar Sharma , Nikhat J. Siddiqi and Bechan Sharma
  Human erythrocytes are an excellent model system to study interaction of pro-oxidants with membranes. The present study, was carried out to evaluate the in vitro antioxidant properties and protective effects of silymarin (milk thistle) in human erythrocyte against tert-butyl hydroperoxide (t-BHP), a potent oxidative stress inducer chemical. Protective effect of silymarin was assessed in vitro by monitoring the antioxidant marker glutathione (GSH) and malondialdehyde (MDA) in three groups of erythrocytes: (I) vehicle control, (II) tert-butyl hydroperoxide incubated group and (III) t-BHP co-incubated with various concentrations of silymarin. The effects of silymarin on lipid peroxidation MDA and GSH content in erythrocytes were assessed. It was observed that activity of GSH was significantly decreased and the malondialdehyde levels were elevated when human erythrocytes were incubated with tert-butyl hydroperoxide in concentration as well as time dependent manner. The protective effect of silymarin is elucidated by the significant reversal of the GSH content and malondialdehyde reduction in human erythrocyte. Therefore the results of our present study suggested that silymarin possess substantial protective effect against in-vitro induced oxidative stress damages by t-BHP.
  Ankush Gupta , Sangram Singh , Farrukh Jamal , Som Nath , Sudhir Mehrotra and Bechan Sharma
  In this study, the potential synergistic relationship between reduced glutathione and vitamin E on ethanol toxicity in isolated rat hepatocytes were examined. It was observed that treatment of ethanol (5-25 mM) caused decrease in cell viability but in presence of Rotenone, cell viability decreased to a greater extent. Inhibitory concentration (IC50) was found to be 20 mM of ethanol treated with rotenone (10 μM) for 2 h. Treatment of ethanol with rotenone (20 mM±10 μM) caused increase in lipid peroxidation, increase of lactate dehydrogenase and decrease in reduced glutathione content. Reduced glutathione and α-tocopherol, alone and in combination, were added to hepatocyte suspension in an attempt to protect cells against alcohol induced cell damage. Pretreatment with reduced glutathione and vitamin E independently, increased the cell viability to 78.97 and 70.42%, respectively, but a combination of reduced glutathione and vitamin E increased cell viability to 92.12%. Vitamin E reduced lipid peroxidation by 41.32% but in combination with reduced glutathione decreased lipid peroxidation by 61.15%. The results suggest an interaction between GSH and Vitamin E in protecting ethanol induced hepatocytes damage.
  Nitika Singh and Bechan Sharma
  Background and Objective: Pharmaceutical property of any plant extract is due to the presence of various phytochemicals and also due to the antioxidant potential of the extract. The two plant species namely Argemone mexicana and Thevetia peruviana have great importance due to their medicinal values. The present examination illustrated the phytochemical analysis, total antioxidative potential and DPPH free radical scavenging activities of the leaves extracts of these plants. Materials and Methods: Powdered leaves of plants were extracted by using a Soxhlet apparatus in hexane. Their total antioxidant and DPPH free radical scavenging activities and the qualitative test for flavonoids, quinones, saponins, phenols, steroids, tannins, terpenoids, cardiac glycoside, alkaloid and carbohydrates. Phenols, steroids, tannins, terpenoids, cardiac glycoside, alkaloid and carbohydrates have been performed by using standard protocols. Results: The qualitative phytochemical studies have clearly demonstrated that the plant, Argemone mexicana and Thevetia peruviana contained flavonoids, quinones, phenols, steroids, tannins, terpenoids, cardiac glycoside, alkaloid and carbohydrates. Further, A. mexicana and T. Peruviana displayed 41 and 33 μM g–1 Fe++ FRAP values and 200 μg and 175 μg IC50 values, respectively against DPPH. Conclusion: The results obtained from this study suggested that the leaves extracts from the A. mexicana and T. peruviana rich in phytochemicals and also have antioxidant potential.
  Nitika Singh and Bechan Sharma
  The phytotoxins are small molecules including peptides or proteins obtained from plant sources that are harmful to organisms in very low concentrations. Several phytotoxins have been shown to be involved in pathogenesis and generation of various diseases. Among the most potential effects of phytotoxins, the inhibition of many physiological and biochemical processes in plants as well as in animals is noteworthy. The phytotoxins have been shown to induce production of reactive oxygen species (ROS) by altering the balance between the oxidants/prooxidants and antioxidants through promoting lipid peroxidation (LPO) and depleting the antioxidative cellular reserves. The present review illustrates the recent advances made in research in the direction of understanding the chemical nature of phytotoxins, biochemical consequences due to onset of oxidative stress and alterations at the levels of mitochondrial functions, carbohydrates metabolism and T-cell responses in biological systems.
  Vivek Kumar Gupta and Bechan Sharma
  An Adenosquamous lung (lung cancer) with metastasis is considered as a major leading cause for death in India and around world. Modern drug-targeted therapies have undoubtedly improved treatment to the patients but also have evoked severe side effects such as loss of hairs, weakness, loss of eye sight, vomiting and headache. Organ failure and immunosuppression due to the modern drug-targeted therapies are also the reasons for death of the adenosquamous lung patients. However, the advanced stage of adenosquamous lung with metastasis remained untreatable at present. So, there is a need for the safer and cost effective drugs with enhanced efficacy. The herbal therapies are being advocated in order to address the above-mentioned issues. The active ingredients of herbal compounds have been reported to detoxify and remove reactive substances generated by carcinogenic agents. The phytochemicals are known to possess anti-proliferative, anti-mutagenic and anti-carcinogenic properties and therefore have the potential to induce death of adenosquamous lung cells. A thorough search of the scientific literature available till date was carried out independently in the scientific databases and search engines such as Cochrane Library, Embase, Medline, PubMed Central, Web of Science and the libraries for original researches. In our analysis, the data were independently extracted by using standard data extraction method. Phytochemicals or plant-based principles are being exploited as emerging strategies for the prevention, delaying and/or impeding the occurrence of lung cancer and also curing the patients. This review summarizes an updated account of research in adenosquamous lung treatment strategy employing phytochemicals from Indian traditional medicinal plants.
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