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Articles by Bashir A. Ganai
Total Records ( 2 ) for Bashir A. Ganai
  Rafia Rasool and Bashir A. Ganai
  The phytotherapeutic approach is one of the ways for modern drug development and many synthetic drugs are being developed on the prototype analogues isolated from plant bioactive principles. One of such widely used plants is self-heal (Prunella vulgaris L.), an ancient therapy used for pain in the throat, fevers and accelerating wound healing. The different health benefits of P. vulgaris for a wide variety of diseases, including cancers, viral and inflammatory diseases, were recently reported. Many of these effects of P. vulgaris are related to the presence of rosamarinic acid, betulinic acid, prunellin and many other bioactive principles which make the plant interesting for antiviral, immunomodulatory and antiproliferative studies. This article provides a review of the data of this commonly used medicinal plant in number of countries. And in addition directs us for judicious use of such valuable species under scientific supervision so as to yield maximum health benefits.
  Syed Irtiza , Gulzar A. Bhat , Mudasar Ahmad , Hilal A. Ganaie , Bashir A. Ganai , Azra N. Kamili , Seema Akbar and Mudasir A. Tantry
  Background and Objectives: Platanus orientalis also called Oriental plane or Chinar or Boonyi (Platanaceae) is a large, deciduous tree, known for its longevity and spreading crown. The present work describes determination of antioxidant, anti-inflammatory and total phenol content of Platanus orientalis. Materials and Methods: Different extracts of the plant such as stem, root and leaves were prepared in different solvents such as chloroform, methanol and water. Results: Total phenol content in this plant reveal that methanol extract of Platanus orientalis root showed maximum free radical scavenging activity followed by methanol wood extract. Antioxidant activity of the plant extracts in this study reveal that it is methanol and chloroform extracts which showed above 50% inhibition in contrast to aqueous extracts. Anti-inflammatory activity of Platanus orientalis showed that aqueous wood extract of Platanus orientalis showed maximum activity in contrast to other extracts. With the help of acute toxicity test it was found that all the extracts are nontoxic at 2 g kg –1 b.wt. to Wistar rats. Conclusion: These finding provides some biological value of different extracts of Platanus orientalis for the use as antioxidant and anti-inflammatory agents. However, further investigation on isolation and purification of the bio-active molecules is needed to explore the exact mechanism of action of the Platanus orientalis extracts.
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