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Articles by Bashar Mudhaffar Abdullah
Total Records ( 3 ) for Bashar Mudhaffar Abdullah
  Bashar Mudhaffar Abdullah and Jumat Salimon
  The lipid fraction of Malaysian rubber seed was extracted and analyzed for toxicological compounds such as linamarin. Analytical methods (rat’s toxicological test and brine shrimps test) were applied to determine the presence of such compounds. Malaysian rubber seed oil was extracted using different solvents (hexane and chloroform+methanol). The oil was found not to contain unusual fatty acids and it is rich in essential unsaturated fatty acids, particularly linoleic (37.28±0.10%) and linolenic (19.22±0.21%). Malaysian rubber seed oil showed no toxic potential toward the rats. Bioassay experiments, in which shrimps were used as test organisms, were performed to evaluate the toxicity of linamarin extracted from the oil. The median lethal concentration (LC50) was found to be 211.70%. The results showed no acute toxicity effects, probably since Malaysian rubber seed oil was not found to contain any hazardous linamarin.
  Firas Hassan , Ayah Abdul Hameed , Ahemd Alshanon , Bashar Mudhaffar Abdullah , Hasniza Zaman Huri , Nany Hairunisa and Emad Yousif
  Multipara metric analysis of compound toxicity at the level of individual cells using flow cytometry and cellular imaging-based approaches such as High Content Screening (HCS) have played key roles in the detection of toxicity and classification of compounds based on observed patterns of reversible and irreversible cellular injury. Gold III complex (AuL2) of bidentate ligand derived from the cyclization reaction of Schiff base of 4-amino-5-phenyl-4h-1,2,4-triazole-3-thiol with thioglycolic acid was synthesized and characterized by using melting point, FTIR spectroscopy, 1HNMR, UV-Visible spectroscopy and elemental analysis. The presence of chloride counter ion in complex was supported by conductivity measurement and the presence of hydrated water was supported by thermal gravimetric studies. We examine the cytotoxic effects of gold complex and its ligand in one cultured cellular models (MCF7 cell line) by High Content Screening (HCS) and analysis and cell viability assay (MMT assay). The inhibitory effect of AuL2 on breast cancer cell growth was due to induction of apoptosis as evidenced by annexin V staining and cell shrinkage. The study found that AuL2-mediated lead to disruption of Mitochondrial Membrane Potential (MMP), cell membrane permeability, nuclear condensation, fragmentation and release of cytochrome c from the mitochondria into the cytosol and also suggesting AuL2 as a potential MCF7 inhibitor compared to doxorubicin as positive control. In this study, data showed that gold (III) complex AuL2 may have therapeutic value in breast cancer treatment worthy of further development.
  Krisna Veni Balakrishnan , Bashar Mudhaffar Abdullah , Hasniza Zaman Huri , Nany Hairunisa and Narazah Mohd Yusoff
  Human immuno-deficiency virus (HIV) disease continues to be a serious health issue for parts of the world. Worldwide, there were about 2.5 million new cases of HIV reported in 2011. The HIV continues to be a major global public health issue with approximately 34 million people living with HIV in 2011. However, the development of anti-viral has blunted the AIDS epidemic in the western world but globally the epidemic has not been curtailed. Negative Regulatory Factor (Nef) is one of the accessory genes found only within HIV and SIV genomes and thought to play a key role in the progression to AIDS. Nef is considered as a potential anti viral target for preventing or at least delaying HIV pathogenesis. It suggesting that, the Nef protein that was detected not identically synthesis through post translation modification though it was expressed in the cytoplasm of HEK 293 cells. The ability of not expressing the targeted myristoylated 27 kDa Nef protein was to various unpreventable factors due to time limitation and lacking of skills in the filed cloning and cell culture.
 
 
 
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