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Articles by Bahram Amouoghli Tabrizi
Total Records ( 2 ) for Bahram Amouoghli Tabrizi
  Daryoush Mohajeri , Bahram Amouoghli Tabrizi , Ghafour Mousavi and Mehran Mesgari
  This research was performed to characterize the hypoglycemic and pancreas-protective effect of ethanolic extract of Crocus sativus L. stigma in alloxanized diabetic rats. The ethanolic extract of Crocus sativus L. stigma was administered orally and intraperitoneally at different doses (20, 40 and 80 mg kg 1) to normal rats. The dose of 40 mg kg 1 was found to be more effective dose in IP route and it decreases Blood Glucose Level (BGL) by 33.9% in normal healthy rats after 6 h of administration. Although, oral route of C. sativus L. also caused significant reductions of blood glucose levels in healthy rats, the effect was minor. The extract administered by IP route at this dose showed an acute hypoglycemic effect in mild and severely alloxan-diabetic rats. Treatment of mild (FBG 120-250 mg dL 1) and severely (FBG 250-300 mg dL 1) diabetic rats for 14 days with the more effective dose (40 mg kg 1) reduces the fasting blood glucose by 41.4% in Mild Diabetic (MD) and 30.7% in Severely Diabetic (SD) rats. After daily treatment with the same dose (40 mg kg 1) of ethanolic saffron extract for 14 days to normal as well as MD and SD rats, the plasma insulin levels were assayed. Serum insulin level showed significant increase in diabetic rats (33.3% MD, 27.3% SD). The histopathological studies of pancreas in ethanolic extract treated diabetic groups showed a reversed damage caused by alloxan to the pancreatic islets as almost normal appearance. The findings of our study indicate the hypoglycemic and potential antihyperglycemic nature of the extract, helping in regeneration of damaged pancreas in experimental dibetes.
  Hamid Mirzaei , Bahram Amouoghli Tabrizi , Ali Hasanpour , Alireza Babapour and Guity Karim
  The potential use of probiotics in restoring the urogenital and gastrointestinal health has received tremendous interest in the last decade, while few safety concerns are still being debated. Effect of oral administration of different doses of probiotic Lactobacillus casei 01 on the haematological parameters, serum protein and albumin of albino rats was investigated. Thirty two rats divided into four groups (A, B, C and D) of 8 rats per group were used. Group A was placed on the basal diet with pure milk alone, while group B, C and D were placed on the diet and also treated with 32, 64 and 96 mL of 107 cfu mL 1 of milk cultured of Lactobacillus casei 01, respectively for 45 days. Blood samples were collected by carotid artery cannulation for terminal bleeding into potassium EDTA containers. Parameters were determined using autohaematological analyzer. Results show there are significantly increase (p<0.01) in PDW, PMV and lymphocytes% by control group rats when compared to the other group rats. In rats treated with lowest doses of Lactobacillus casei 01 there were significantly increase (p<0.01) in Total protein, albumin, WBC and Mid amount when compared with the control, also amount of Granulocytes, HGB, RBC count and HCT in the highest dose group of Lactobacillus casei 01 are significantly highest (p<0.01) except RDW-CV that it was significantly increase (p<0.01) to the C group rats when compared with control group. In other parameter was not found meaningful different (p<0.05). The data obtained showed that milk fermented Lactobacillus casei 01 is safe and it has immunostimulatory effect. Its effect on haematological parameters was dose dependent.
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