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Articles by B.A. Salau
Total Records ( 3 ) for B.A. Salau
  B.A. Salau and E.O. Ajani
  Alterations in plasma lipid profiles are common occurrences in diabetes. There is also a positive correlation between the risk of developing ischaemic heart disease and raised plasma cholesterol and LDL-cholesterol. Musa sapientum sucker extract has proven to be an effective antidiabetic agent by lowering blood sugar level and improve the islets of Langerhans. In this study, effect of different concentrations of methanolic extracts of Musa sapientum sucker on plasma lipid profile were assessed in alloxan induced diabetic rats. Total plasma cholesterol, HDL cholesterol and triglyceride were determined using enzymatic kits, while plasma LDL cholesterol, VLDL cholesterol, atherogenic and coronary risk indices were calculated. The extract at 5 mg and 10 mg/kg/body weight/day reduced significantly (p<0.05) the total plasma cholesterol, very low density lipoprotein cholesterol and plasma triglyceride. Administration of the extract also reduced significantly (p<0.05) the atherogenic and coronary risk indices. However, a significant increase (p<0.05) was observed in plasma HDL cholesterol. The result of the study indicates that Musa sapientum sucker extract was effective in improving plasma lipid profile associated with cardiovascular risk factors in alloxan induced diabetic rats.
  B.A. Salau , W.E. Olooto , O.L. Adebayo , E.O. Ajani , K.T. Odufuwa and J.O. Olowookere
  Effects of various concentrations of sucrose diet were assessed on thirty weaning male albino rats divided randomly into five equal groups as follows: G1 (baseline group); G2 (control group given rat chow only); G3, G4 and G5 (groups with energy supply from sucrose at 10, 20 and 30%, respectively). The four groups were fed for twelve weeks and then fasted overnight. They were then anaesthetized with diethyl ether and venous blood was collected using cardio puncture method. Plasma was collected by centrifugation and total plasma cholesterol, HDL cholesterol and serum Triglycerides were assayed using Randox enzymatic kit while VLDL cholesterol, LDL cholesterol, Atherogenic index and coronary risk indices were calculated. Sucrose diet increased energy density. It also increased significantly (p<0.05). Plasma total cholesterol, LDL cholesterol, VLDL cholesterol, Triglycerides, Atherogenic and Coronary risk indices while it decreased HDL cholesterol. Present results indicated that sucrose diet at present level of consumption (about 25% energy supply) elevated cardiovascular risk factors in male albino rats and may predispose one to cardiovascular diseases.
  B.A. Salau , M.M. Adeyanju , K.T. Odufuwa and O. Osilesi
  Fruits and vegetables have been shown to contain vital components that moderate disease conditions. However, there is dearth of information of these effects in Africans diabetic subjects. Thus, we investigated the relative effect of fruits and vegetables on some selected heamorological factors associated with cardiovascular disease in diabetic subjects. Thirty diabetic subjects were selected at the cardiovascular clinic of Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. The subjects with mean Fasting Blood Glucose (FBG) level of 7.8±0.95 mmold L-1 were placed on 300 g of fruits and vegetables per day, while they continued their normal medication and food intake. A significant difference (p<0.05) was noticed between baseline and eight week values in all the parameters, Fibrinogen 262.75±2.64 to 250.57±3.98 mg dL-1, Blood viscosity, 5.96±0.21 to 4.82±0.23 m Pas; erythrocyte sedimentation rate 49.40±2.34 to 32.8±1.26 min h-1 and haematocrit 38.8±1.25 to 44.75±1.05%. At the eight week the fruits and vegetables were withdrawn for two weeks and the above parameters were reassessed (at the 10th week) which were compared with eight week values. Significant difference p<0.05 was noticed in E.S.R. 32.8±1.26 to 38.8±1.23. However no significant difference (p>0.05) was observed in haematocrit, 44.75±1.44 to 42.70±1.24, Fibrinogen, 254.5±3.98 to 250.57±3.16 mg dL-1. The results showed that regular intake of fruits and vegetables by diabetic subjects may reduce cardiovascular risk factors.
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