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Articles by Arvind Soni
Total Records ( 2 ) for Arvind Soni
  Arvind Soni , Manu Chaudhary and Vivek Kumar Dwivedi
  The aim of the present study was to evaluated the effect of the VRP 1020 in reconstitution with fixed dose combination of ceftriaxone-vancomycin (Vancoplus). The mice were fed standard pelleted diet and water ad libitum. The test room was air conditioned with temperature 23±20°C, humidity 65±5% and with artificial fluorescent light (10-14 h) of light and dark, respectively. Thirty Mus musculus mice (weighing 30±5 g) were divided into 5 groups containing 6 mice in each group. Group I: control (normal saline), group II: ceftriaxone (28.57 mg kg-1 body weight/day) group III: vancomycin (14.2 mg kg-1 body weight/day), group IV: ceftriaxone-vancomycin (42.8 mg kg-1 body weight/day) and group V: ceftriaxone-vancomycin+VRP 1020 (42.8 mg kg-1 body weight/day). Present finding showed that activities of antioxidant enzymes (superoxide dismutase and catalase) and pyridoxal-5-phosphate level (biologically most active co-enzyme of vitamin B6) were significantly increased along with decreased in lipid peroxidation (malonaldialdehyde) level in vancoplus treated group as compared to ceftriaxone and vancomycin alone and combination of ceftriaxone-vancomycin treated group. Similarly, the levels of extracellular antioxidant (creatinine and uric acid) were found to be significant lowered in vancoplus treated group when compared to ceftriaxone, vancomycin and ceftriaxone-vancomycin treated group. These results indicated that reconstitution of VRP 1020 with fixed dose combination of ceftriaxone-vancomycin protects against ceftriaxone and vancomycin induced nephrotoxicity that improved the activities of free radical scavenging enzymes.
  Arvind Soni , Alka Niveden , Virendra Nath and Anil Kumar
  Random amplified polymorphic DNA markers were used to determine the altitudinal variation within and between Plagiochasma appendicualtum collected from different altitude of Western Himalaya especially from Mussoorie region of India. Findings of UPGMA cluster analysis and band frequency of all the nine accessions were separated according to their altitudes supporting to their morphological differences as well. Gene flow and spore dispersal plays an important role in the polymorphism. Gene flow within P. appendiculatum growing on same altitude is very high as compared to accessions collected from different gradient of altitudes i.e., the genotypes collected from same altitude showing not so much polymorphism compared to different altitude. It has been concluded that the RAPD markers would be useful to characterize the altitudinal variation between different accessions of P. appendiculatum and may be also valuable to other bryophytes collected from various environmental condition.
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