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Articles by Alireza Sarkaki
Total Records ( 7 ) for Alireza Sarkaki
  Hojjat Allah Alaei , Mahmoud Hosseini , Alireza Sarkaki , Nasser Vahdati-Mashhadian and Asieh Naderi
  The aim of this study was to investigate the effects of Ang II and captopril on altering the motivational aspects during the initiation of morphine self-administration. Male Wistar rats were first trained to receive small pellets of food by pressing the active lever in self-administration apparatus. They were anaesthetized with Ketamine and their jugular vein was cannulated. The stainless steel cannula was also inserted into the right brain ventricle and fixed with dental cement. After recovery, the animals were divided into 4 groups (saline, morphine, captopril and Ang II) and placed in self-administration apparatus and allowed to self-administer morphine (1.7 mmol per infusion all test groups) or saline (saline group) during 11 consecutive days for 2 h/sessions. Captopril (300 mmol) and Ang II (1 nmol) injected (i.c.v.) in the corresponding groups before each session. The number of active and passive levers pressed in each group was recorded. After the last session, morphine withdrawal signs were recorded following naloxone injection. In morphine group, the number of active lever pressing was significantly higher than passive one in all 11 days (p<0.01) and was also significantly higher than the saline group in the final three days (p<0.05). In captopril group, there were no significant differences between the number of active and passive lever pressings during free access to food (last 5 days). However, the number of active lever pressing was significantly lower than morphine group (p<0.05). Some of the withdrawal signs decreased and increased significantly in captopril and Ang II groups, respectively. This study implies the interaction between captopril and opioid system.
  Fakher Rahim , Bijan Keikhaei , Alireza Sarkaki and Abdol Hassan Doulah
  The present research was conducted in order to investigate the effects of right-unilateral lesion of substantia nigra neurons by means of Ibotonic acid, a cholinergic-selective neurotoxin, on hematological parameters in rats. Thirty male Wistar rats weighing 200±50 g at the start of the experiment were used. The substantia nigra was right-unilateral lesioned by stereotaxic microinjections of 8 μg (free base) ibotonic acid, dissolved in 4 μL physiological saline containing 0.1% ascorbic acid, administered through the Hamilton microsyringe over 4.50 min. Seven days after neurosurgery, we assessed the total number of White Blood Cells (WBC), the total number of Red Blood Cells (RBC), Red cell Distribution (RDW), platelet and hemoglobin level and the erythrocyte indexes, Mean Cell Volume (MCV), Mean Cell Hemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC). Ibotonic acid treatment induced a highly significantly decrease of white blood cells (p<0.001), followed by significant decrease in red blood cells (p = 0.02) and hemoglobin level (p = 0.03) comparative with sham-operated rats. Also, in the ibotonic acid-lesioned rats the erythrocyte indexes, Mean Cell Volume (MCV) (p = 0.04); Mean Cell Hemoglobin (MCH) (p = 0.02)) were significantly decreased comparative with sham-operated rats. By contrast, in the ibotonic acid-lesioned rat's platelet (0.34), Mean Cell Hemoglobin Concentration (MCHC) (p = 0.41) and Red blood cell Distribution Width (RDW) (p = 0.03) were significantly enhanced comparative with sham-operated rats. On the whole, the obtained data indicate the important role of the central nerves system in the regulation of erythrocyte dynamics.
  Mohammad Badavi , Fatemeh Zarea Mehrgerdi , Alireza Sarkaki , Mohammad Kazem Gharib Naseri and Mahin Dianat
  The main objective of this study was to evaluate the potential protective effect of red Grape Seed Extract (GSE) on lead induced hypertension (HTN) and Heart Rate (HR) in male Wistar rats. The rats were randomly assigned to one of 4 groups: Each group received lead acetate (100 ppm in drinking water), GSE (100 mg kg-1, orally) or Lead + GSE for 45 days. Another group assigned as control group provided with tap water and regular pellet food. The Systolic Blood Pressure (SBP) and heart rate were determined by tail plethysmography coupled to a computer system. There was a sustained elevation of SBP in lead exposed rats that significantly increased at day 18 (lead treated, 112.7 ±2.7 mmHg, vs. control, 105.6±2.6 mmHg, n = 10, p<0.05) and reached a maximum level at day 36 (lead treated, 124.9 ±2.3 mmHg, vs. control, 103.6 ±3.1 mmHg, n = 10, p<0.001). However, the other three groups; showed no significant changes in SBP. Furthermore, the heart rate was increased sustainly in lead exposed animals that was statistically significant at days 36 and 45 (lead treated group, 404.5±9.4 vs. control group, 381.7 ±6.7, n = 10, p<0.05). The blood lead level in both lead and lead + GSE treated groups was increased significantly compared with control and GSE treated groups (p<0.001). However, GSE administration had no effect on the blood lead level in lead treated group. According to the result of this study, it may be concluded that GSE could have beneficial effect in protecting the cardiovascular system through its antioxidant activity against oxidative stress.
  Alireza Sarkaki , Reza Amani , Mohammad Badavi , Ahmad Z. Moghaddam , Hadi Aligholi , Maryam Safahani and Mohammad H. Haghighizadeh
  The aim of this study was to evaluate the effects of different doses of dietary soy meals (with or without isoflavone) on dementia in ovariectomized (OVX) animal model of Alzheimer`s disease. Female Wistar`s rats with the exception of intact group were ovariectomized at the first line of study. Animals were divided into 2 main groups: control (c) and pre-treatment groups. Animals in pre-treatment groups received one of five types of diet during four weeks prior Nucleus Basalis Magnocellularis (NBM) electrical lesion normal diet (0), 10 g soy with isoflavone (10), 20 g soy with isoflavone (20), 10 g soy without isoflavone (-10) and 20 g soy without isoflavone (-20) in 30 g daily diet. The spatial learning and memory were tested using Morris water maze after electrical lesion. Rats were trained in water maze to find a hidden escape Platform. Rats received 6 blocks that each block consisted of 3 trials. Following acquisition trials, one probe trial was conducted in which the platform was removed. Soy meal diet (with or without isoflavone) in ovariectomized rats with Alzheimer`s disease caused improvement of performance across 18 trials of Acquisition. Our results suggest that soy meal is a potential alternative to estrogen in the prevention and treatment of Alzheimer`s disease.
  Maryam Jafar Sameri , Alireza Sarkaki , Yaghoub Farbood and Seyed Mohammad Taghi Mansouri
  The aim of this study was evaluation the effect of Gallic acid on movement disorders and pallidal electrical power in animal model of Parkinson’s Disease (PD). PD is clinically characterized by development of motor disturbances, such as bradykinesia, resting tremors, rigidity and a later loss of postural reflexes. Oxidative stress is a hallmark factor where the oxidation of dopamine generates Reactive Oxygen Species (ROS) and an unbalanced production ROS induces neuronal damage, therefor leading the neuronal death. Gallic Acid (GA) and its derivatives are present in the plant kingdom and acts as a potent antioxidant. Wistar male rats devided into seven groups randomly with 8 in each. Animals in all groups except control received 8 μg/2 μL 6-hydroxydopamine dissolved in normal saline contains 0.01% ascorbate or vehicle in right Medial Forbrain Bundle (MFB) and a bipolar wire electrode was implanted in the left globus pallidus nucleus of all animals under stereotaxic surgery. Two weeks later PD was approved by contralateral rotation signs induced by apomorphine and then movements and electrical power of pallidal were evaluated. Motor functions and pallidal electrical power were impaired and GA could improve motor dysfunctions and gamma wave power in parkinsonian rats’ significantly with higher dose of GA (200 mg kg-1). Present result showed that GA may act as a potent antioxidant and free radical scavenger to reverse motor disorders and pallidal gamma wave power after 6-OHDA neurotoxicity in brain.
  Maryamalsadat Jalali , Masoud Hemadi , Ghasem Saki and Alireza Sarkaki
  Noise stress is dangerous natural contaminant that produces harmful physiological, psychological and morphological outcomes to the body. So this study was conducted in order to investigate the effects of noise stress on the parenchyma of testis. Healthy mature females rats (n = 20) were mated with the mature male rats and then randomly allocated equally either to experimental or control groups. Experimental group has given daily noise stress up to birth their child. In the second step, the child's pregnant rats of experimental group were distributed to three subgroups as follow: group I (without exposure to noise stress), group II (exposure to noise for 8 weeks) and group III (exposure to noise for 14 weeks) for morphometric analysis of their child's testicles by sacrificing of them at weeks 14. In general, the testes of non-exposed group were grown larger than ones in the noise exposed groups. Moreover, the testes of the experimental group 1 were larger than the other experimental groups. Indeed, the rate of atrophic seminiferous tubules and jumbled appearance of the interstitial space were more observed in the noise stress exposed group than non-exposed ones. In addition, seminiferous tubules analysis revealed that the characteristics of interstitial space cells and epithelial germinative cells of the seminiferous tubules in the control group were better than the noise exposed groups. It seems that the noise stress has negative influences on the fertility of male based on enhancing of the apoptotic process induced by pathogenesis stress and suppressing the kinetics spermatogenesis.
  Somayeh Hajipour , Alireza Sarkaki , Seyed Mohammad Taghi Mansouri , Asghar Pilevarian and Maryam RafieiRad
  This study aimed to evaluate the effect of two weeks oral administration of Pomegranate Seed Extract (PGSE) on active avoidance memory and motor coordination activities after permanent bilateral common carotid arteries occlusion (2CCAO) in male adult rats. Adult male albino rats of Wistar strain (250±20 g, 3-4 months) were used. Animals were divided into eight groups with 10 in each: (1) Sham operated (Sh); (2) Ischemic (I); (3) Ischemic received 100 mg kg-1 PGSE, orally (I+E100); (4) Ischemic received 200 mg kg-1 PGSE, orally (I+E200); (5) Ischemic received 400 mg kg-1 PGSE, orally (I+E400); (6) Ischemic received 800 mg kg-1 PGSE, orally (I+ E800); (7) Ischemic received 2 mL kg-1 normal saline, orally (I+Veh); (8) Sham operated received 400 mg kg-1 PGSE, orally (Sh+E400). In order to make 2CCAO an animal Cerebral Hypoperfusion Ischemia (CHI) model, carotid arteries were ligatured and then bilaterally cut. To evaluate active avoidance task, Correct Response Percentages (CRP) was measured by Y-maze apparatus and motor coordination activity was evaluated using standard behavioral tests by rotarod apparatus in all the rats. It was found that memory. Memory and motor coordination activities were significantly impaired in the rats after CHI (p<0.01). PGSE treatment significantly improved impairment of memory and motor coordination in the rats with 2CCAO (p<0.001). PGSE exhibited therapeutic potential for memory and muscular coordination, which was most likely related at least in some part to its antioxidative and free radical scavenging actions.
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