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Articles by Aditi Singh
Total Records ( 3 ) for Aditi Singh
  Aditi Singh , Helen H. Lou , Ralph W. Pike , Adedeji Agboola , Xiang Li , Jack R. Hopper and Carl L. Yaws
  As an emerging discipline, nanotechnology has the potential to improve environmental sustainability through its application in pollution prevention, treatment, remediation, etc. One challenging issue in the growth of nanotechnology is how to produce purified carbon nanotubes (CNT) in commercial quantities at affordable price and with low environmental impacts. A detailed assessment of such a manufacturing process from both economic and environmental aspects at the design phase will benefit both the industry and the society. In this work, an LCA type of environmental impact assessment is conducted for the conceptual design of two catalytic, chemical vapor deposition processes (CNT-PFR and CNT-FBR) used for continuous large–scale production of CNT. The core of both processes is a high-temperature catalytic reactor. Mineral acids are used in the purification steps, from which liquid and solid wastes are generated and must be treated before discharge. Based on the simulation results, the environmental impacts of each process are calculated. The results provide vital information that can be used during the design phase of these processes for better decision-making.
  Parul Tripathi , Suresh K Yadav , Somali Sanyal and Aditi Singh
  Background and Objective: Inherited polymorphisms in carcinogen metabolizing and DNA repair genes may contribute to variations in carcinogen metabolism and DNA repair capacity and thus genetic susceptibility to cancer. This study was performed to evaluate the association between polymorphism of two genes namely XPC and GSTT1 and risk for development of oral lesion. Materials and Methods: In a hospital-based case-control study a total of 46 histopathologically proven leukoplakia, erythroplakia, lichen planus and oral submucous fibrosis patients and equal number of age, sex, ethinicity and habit matched healthy control subjects were taken. Subjects were genotyped for XPC Intron 9 (Ins/Del) polymorphisms with allele specific PCR method: Whereas, XPC Exon 16 (A>C) polymorphism were genotyped by PCR-RFLP. For genotyping of GSTT1, multiplex PCR was used. The association between DNA damage response gene polymorphisms and oral lesion occurring risk was assessed by calculating odds ratios (OR) with 95% confidence intervals (CI). The combined ORs were calculated under the dominant genetic model for each polymorphism. All the statistical analyses were two sided and conducted using the EPIinfo software. Results: Overall, a significant association of XPC poly AT Del/Del (D/D) genotype with increase risk of oral lesion was observed. Similarly AA genotypes for XPC exon 16 variant presented statistically significant p<0.05 increased risk of oral lesions. In contrary, AC and CC genotypes from the same polymorphism found to be protective for the development of oral lesion with OR-0.387 and 0.174, respectively for AC and CC genotype. The study demonstrates that absence of GSTT1 gene increases the risk of developing oral lesions. Conclusion: The present study supports that polymorphism in XPC gene may reduce the risk of developing oral lesions in North Indian population, whereas GSTT1 null genotype increases the risk of oral lesions.
  Apurva K Srivastava , Aditi Singh , Parul Tripathi and Asha Mathur
  More than hundred million people from almost 25 countries, including India, were affected by fluorosis. Thus the objective of the study was to study the prevalence of dental fluorosis in high fluoride areas around Lucknow and to evaluate the role of calcium in dental fluorosis. Water survey from different areas was done to identify high fluoride area in Unnao district of Uttar Pradesh, India. House to house survey of more than 5000 population was done. Biochemical tests were performed in 50 dental fluorotic and 50 non fluorotic randomized subjects. Clinical and biochemical status was recorded after 6 months of calcium supplementation. SPSS was used for statistical analysis. It was showed that 28.64% population had dental fluorosis (total fluorosis: 43%), highest in 13-15 years age group. After 6 months of calcium supplementation, 44% of cases showed reversal of dental fluorosis, whereas, in 40% of them disease did not progress further. Increase in serum calcium and significant decrease in urinary fluoride was observed post supplementation. This first large scale prospective community study, concluded that long term administration of calcium can reverse dental fluorosis especially in children with early grades of fluorosis.
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