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Articles by Abolhassani F.
Total Records ( 3 ) for Abolhassani F.
  Bahmanzadeh M. , Abolhassani F. , Amidi F. , Ejtemaiemehr Sh. , Salehi M. and Abbasi M.

Introduction: Increase in the nitric oxide in the spermatic veins of men by varicocele has been reported. Although Several studies have considered the relationship between varicocele and semen NO concentrations, no study on the effects of nitric oxide synthase inhibitor (L-NAME) on epididymal sperm count, motility and morphology which are important in fertility of the individual has been reported. The aim of study was to evaluate the effects of nitric oxide synthase inhibitor (L-NAME) on epididymal sperm count, motility, and morphology in varicocelized rat.

Methods: Twenty four Wistar male rats divided into four groups. The group A and B underwent a left experimental varicocele (by 20-gauge needle). Group C, underwent a procedure similar to groups A and B without any change on spermatic vein (as sham group). Group D referred to as control. Animals in group A were killed 10 weeks after the operation and both left and right epididymal sperm were counted and their morphology and motility were analyzed. Animals in group B received 10mg/kg L-NAME intraperitoneally daily for ten weeks.

Results: In group A, Sperm count decreased and the morphology changed significantly in comparison with the groups C and D. The sperm morphology in groups A and B showed statistically significant differences (P<0.0001). Sperm motility decreased significantly in the group A in comparison with the groups C and D. Although motility in group A of animals were different in comparison with group B , it was not statistically significant.

Conclusion: These findings suggest that nitric oxide synthase inhibitor (L-NAME) improved sperm count and morphology.

  Alizadeh, N. , Abbasi M. , Abolhassani F. , Amidi F. , Mahmoudi R. , Hoshino Y. , Sato E and Ragerdikashani I.
  Backgrounds and the purpose of the study:Inducible NO synthase activity has been frequently reported in varicose veins. Aminoguanidine is known to inhibit iNOS. The aim of this study was to examine the effects of aminoguanidine on varicocelized rats.
Methods:Male Wistar rats were divided into groups A, B, C, D, E, and F (control group). Groups A, B, C, and D rats underwent left varicocele induction with a 20-gauge needle. Group E (sham) rats underwent a similar procedure, but the renal vein was left intact. Ten weeks after varicocele induction, sperm parameters were evaluated in groups D, E, and F. Groups A and B received 50 mg/kg aminoguanidine or placebo, respectively, daily for 10 weeks. After 10 and 20 weeks of varicocele induction, the fertility outcomes of the experimental groups were evaluated .
Results: The values of the sperm parameters did not differ significantly between groups B and D, but were significant when compared with groups F and E (P ≤ 0.05). The values of the sperm parameters of groups F and E showed no significant changes (P ≤ 0.05). The changes between group A and groups B and D were significant (P ≤ 0.05). Ten weeks after varicocele induction, rats of groups A, B, and C were still fertile. After 20 weeks, only half of the rats in group A were fertile. Conclusions: Aminoguanidine improved the sperm parameters and mating outcomes in vari-cocelized rats.
  Pourmalek F. , Abolhassani F. , Naghavi M. , Mohammad K. , Majdzadeh R. , Naeini K. Holakouie and Fotouhi A.
  We estimated the life expectancy for 2003 for 23 provinces in the Islamic Republic of Iran using population and mortality data from the Ministry of Health and Medical Education. The underreporting of deaths above 4 years was corrected using the Brass Growth Balance method. We assumed that the distributions of population, deaths, and hence life expectancy in the 23 provinces were equal to those for all 28 provinces of the country. Thus we estimated life expectancy at birth to be 71.56 years for the total population [95% uncertainty interval [UI]: 71.52-71.62]; 70.09 [95% UI: 70.02-70.16] years for males, and 73.17 [95% UI: 73.10-73.24] years for females. Our estimates were higher than the model-based estimates of the Statistical Centre of Iran, United Nations agencies and the World Bank, due to differences in the estimation methods used.
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