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Articles by Abhijit Dey
Total Records ( 14 ) for Abhijit Dey
  Abhijit Dey and J.N. De
  Rauvolfia serpentina (L). Benth. ex Kurz. (Apocynaceae) has long being used in India for the treatment of snakebites and mental illness. It also controls hypertension and reduces blood pressure. The present review deals with the enormous amount of studies undertaken in different aspects of this plant in the areas of tissue culture, phytochemistry, pharmacology, molecular biology, chromosomal constituents, morpho-taxonomy, medicine and ethnobotany.
  Abhijit Dey and Jitendra Nath De
  Aristolochia indica L. (Aristolochiaceae) has long been used in Indian subcontinent in the traditional system of medicine to treat cholera, fever, bowel troubles, ulcers, leprosy, skin diseases, menstrual problems and snakebites. The plant is also used as emmenagogue, abortifacient, antineoplastic, antiseptic, anti-inflammatory, antimicrobial, antipyretic, antifertility and antispermatogenic agent. Aristolochic acid, a major active constituent of the plant is reported to cause cancer, nephropathy, sister chromatid exchange and is a potent abortifacient. The present review deals with the different scientific studies and reports available in different aspects of this plant in the areas of Morpho-taxonomy, Phytochemistry, Pharmacology, Medicoethnobotany, Tissue culture and Chromosomal study.
  Abhijit Dey and J.N. De
  The westernmost district of West Bengal, Purulia is inhabited by a large number of tribals. A study on the ethnoveterinary practices of medicinal plants was carried out in this area. Through questionnaire, personal interviews and conversation, a total number of 25 plant species used by the aboriginals were enumerated. The major ethnic groups present in the studied area include Santhali, Bhumijs, Mundas, Oraon, Birhor, Mal Pahariya, Kharia and Ho. During the investigation, a well developed system of ethnoveterinary practices was found among these tribals.
  Abhijit Dey and Jitendra Nath De
  Venomous snakebite has been a major cause of mortality and morbidity across the Asian, African and Latin American countries. Lack of medical infrastructure, ineffectiveness of conventional antivenin and malpractice by the local quacks worsen the scenario. The present review deals with the pharmacological investigations performed in different botanicals for antiophidian principles. It also includes a list of certain traditionally used medicinal plants with potential anti snake venom efficacy. The authors have compiled a number of plants active in vitro and/or in vivo against the toxicity of various snake venoms causing an array of biological symptoms. This review also compiles the information regarding the possible use of plant derived natural product based antivenins in order to find cheap and effective alternative source of snake venom antidote especially for the third world tropical countries. From a variety of literature sources the data has been collected mentioning the plants alphabetically and their respective families with notes on plant parts and solvent system used, in vitro and in vivo analyses, activity against the toxicity and biological symptoms related to poisonous snakebite, dose dependence, experimental models, efficacy of the isolated compound(s), ethnobotanical and clinical relevance etc.
  Abhijit Dey , Arijit De , Pinky Ghosh and Souryadeep Mukherjee
  Herbal remedy is considered as one of the popular forms of alternative and complementary medicines. Plants are considered to possess a number of chemical constituents with diverse pharmacological efficacies. Bryophytes, a small group of plants, are known to contain unique secondary metabolites having pharmacological and potential therapeutic value. The primary focus of the study is to depict the role of altitude and tissue types on antioxidant capacity of the liverwort Pellia endiviifolia (Dicks.) Dumort. (Pelliaceae). In the present investigation, an attempt has been made to explore the antioxidative potential of vegetative and reproductive tissues of P. endiviifolia collected from five different altitudes of Darjeeling Himalaya, West Bengal, India. Total phenolics and flavonoids contents of the liverwort samples were also determined. Methanol extract of the thalloid liverwort was investigated for antioxidant activity by DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, total phenolic and flavonoid estimation. Maximum radical scavenging activity was found to be 89.336%±4.3. Maximum total phenolics content in 1 mg of the extract was 58±0.175 μg of Gallic Acid Equivalent (GAE) per mg dry weight. Maximum flavonoids content in 1mg of the extract was 80.3±331 μg of Quercetin Equivalent (QE) per mg dry weight. The results indicate, for the first time, the antioxidative potential and possible use of the liverwort as a natural antioxidant. It also shows a variation of antioxidant capacity of the liverwort depending on their tissue type and their altitude of occurrence.
  Amrita Dey , Abhijit Dey and Jitendra Nath De
  Not Available.
  Abhijit Dey , Trisha Das and Souryadeep Mukherjee
  Medicinal plants serve as sources of valuable compounds with therapeutic potential. Plumeria rubra L. (Apocynaceae) is a medicinally important tree which has been reported as ethnomedicinal cure of different ailments. In the current investigation, n-hexane fraction of crude methanolic extract of P. rubra stem bark was investigated against four ATCC (American type culture collection) bacterial strains Staphylococcus aureus (ATCC 25923), Enterobacter cloacae (ATCC 13047), Pseudomonas aeruginosa (ATCC 27853) and Serratia marcescens (ATCC 13880). Inhibitions of the plant extract against all the four microorganisms were tested by both agar-diffusion assay and broth microdilution method. The n-hexane fraction of crude methanolic extract of P. rubra stem bark showed MICs of 13.5, 11.8, 8.5 and 16.9 mg mL-1 and induced a maximum of 91.53, 92.84, 94.69 and 85.29% growth inhibition against S. aureus (ATCC 25923), E. cloacae (ATCC 13047), P. aeruginosa (ATCC 27853) and S. marcescens (ATCC 13880), respectively. The active plant extract in this study showed significant antibacterial activities against all the human pathogenic strains, adding credence to the ethnomedicinal uses of the plant, as well as, suggesting towards its specific use against the tested microorganisms.
  Abhijit Dey and Anuradha Mukherjee
  Plumeria rubra L. (Apocynaceae) is a deciduous ornamental tree species with fragrant flowers native to Mexico, Central America, Colombia and Venezuela but also cultivated in tropical and subtropical countries. The plant is known to possess biological activities viz., antibacterial, antifungal, antiviral, antialgal, larvicidal, molluscicidal, piscicidal, nematicidal, antioxidative and free radical scavenging, hypolipidemic, proteolytic, cytotoxic, abortifacient activities etc. A number of phyto-constituents are reported from the plant which signifies biological activities and diverse ethnomedicinal uses of this plant species. The present review deals with the literature involving ethnobotany, phytochemistry and pharmacology of the plant.
  Abhijit Dey and Amrita Dey
  Insomnia or sleeplessness is a disorder characterized by a personal incapability to falling or staying asleep for a desirable period of time. Apart from Valeriana officinalis and Ziziphus jujuba most of the ethnobotanicals used for sleep disorders have not been evaluated for pharmacological or clinical efficacy against insomnia. Chinese herbal medicines involving polyherbal formulations are yet to be characterized and long term side effects are yet to be evaluated. Anti insomniac phytotherapy opens up an exciting aspect of research which might benefit a large number of patients suffering from different degrees of insomnia.
  Abhijit Dey , Amrita Dey and Jitendra Nath De
  Scorpion bite is considered as one of the common and dangerous phenomenon throughout the world. The clinical manifestations include pulmonary edema, myocardial damage, intracerebral haemorrhage, brachial plexopathy, renal failure etc. which sometimes leads to mortality. The common antivenin therapy includes anti-scorpion venom serum or prazosin. In the vast rural areas of the third world countries phytotherapy is considered as an alternative system of medicine and scorpion sting is treated with the help of medicinal botanicals. As the safety and efficacy are considered as important aspects of anti venin therapy, conventional treatment can be supported by the herbal remedy. The present review compiles a number of medicinal plants pharmacologically evaluated in vitro and/or in vivo for scorpion antivenin properties. Considering the aspects like cost effectiveness, availability, lesser side effects and development of drug resistance, plant based anti venin therapy may be considered as a possible remedy against scorpion envenomation.
  Abhijit Dey and Jitendra Nath De
  Background: Bryophytes, phylogenetically placed between the algae and the vascular plants, are divided into three classes viz. Liverworts, Hornworts and Mosses. This small, slow-growing group of plants is often associated with disturbed habitat, barren rock surface and extreme climatic condition. Traditional system of medicine throughout the world has been utilizing the small group of plants to treat various ailments. Recent pharmacological investigations have proven that the active principles present in the group are quite unique and having tremendous therapeutic potential. Compounds present in bryophytes have been investigated for antiinflamatory, antimicrobial, antioxidant, antivenomous and cytotoxic activity. Bryophytes possess strong antioxidative enzymatic machinery which helps them to cope up with extreme climates and stresses. Results: The present review deals with the literature covering the potential of bryophytes as antioxidative agent, pharmacological investigations of antioxidants and induction of antioxidative system due to different kinds of stress viz. heavy metals, desiccation, radiation, salt etc. A number of antioxidative enzymes were found to be activated due to stress response. Some bryophytes were found to hyperaccumulate metals, some were able to sequester the toxic metal ions. These bryophytes are used as biomonitoring agents. Conclusions: In the present study the authors have found several reports of antioxidative properties found in liverworts and mosses. Herbs have already been used as a potent source of antioxidant in cosmetic and food supplement industry. Bryophytes can serve as a natural source of antioxidants which can be exploited in medicine and cosmetics. Although, the clinical efficacy of the active principles are subjected to further investigation, the therapeutic potential of this small plant group should not be ignored.
  Abhijit Dey and Jitendra Nath De
  Background: Leprosy, an infectious disease, caused by bacteria Mycobacterium leprae and Mycobacterium lepromatosis has been known since biblical times. The disease is associated with damage of the skin, nerve, limbs and eyes. It has a long incubation period and children are more susceptible. Common forms of leprosy are tuberculoid and lepromatous and a few intermediates. It is not very contagious and tentative mode of transmission is respiratory droplets. The disease is widespread throughout the tropical, subtropical and temperate regions of the world but is prevalent among the underprivileged of the third world countries. Results: The present review deals with the literature covering the use of antileprotic plants, their pharmacological investigations and ethnobotanical remedy of the disease. The authors have tried to bridge between the folklore use of the herbs and their pharmacological investigations for antileprotic properties. Conclusions: Although different antileprotic drugs are available in the market, herbs and herbal constituents have been neglected as a possible remedy. Most of the present treatments are difficult, time consuming, expensive and with adverse side effects. Development of drug resistance in the bacteria is another major concern worldwide. Considering the facts, herbal remedy can be an exciting aspect in the treatment of the disease with less side effects and at a reasonable cost. The vast ethnic knowledge inherited by the local medical practitioners can be exploited scientifically to find out novel antileprotic compounds.
  Abhijit Dey and Jitendra Nath De
  Fungi are associated with a number of plant and human diseases. Plant extracts have been used as efficient fungicides inhibiting the growth of many fungal pathogens. Bryophytes, a small group of lower plants, evolutionarily placed between the algae and the pteridophytes, have been reported to store a number of compounds having antifungal efficacy. This review includes a list of bryophytes investigated against a number of plant and human pathogenic fungi with special reference to the compounds, nature of the compounds, name of the fungi and mode of action on the basis of available information. Bisbibenzyl was found to be the predominant antifungal active principle present in the bryophytes showing efficacy by inhibiting different types of biological activities of the pathogens.
  Abhijit Dey and Anuradha Mukherjee
  An ethnobotanical survey was conducted in the Purulia district, India in order to explore the use of plants as fodder as a part of the traditional livestock husbandry practiced by the aboriginal groups such as Santhal, Bhumija, Munda, Oraon, Birhor, Mal Paharya, Kharia, Kharwar, Gond and Ho. A total number of 103 informants (78 males and 25 females) were chosen for the interviews and 33 ethnobotanicals were reported as fodder plants for the domesticated animals. Poaceae and Moraceae represent maximum number of forage plants (6 each) whereas, leaves represent the most prolific plant part consumed by the animals. Aspects such as nutrient and anti-nutrient content, pharmacological and neutraceutical significance of the forage plants were added which reflects the scientific and economic aspects of such folkloric uses.
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