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Articles by Abdul-Wahab R. Hamad
Total Records ( 3 ) for Abdul-Wahab R. Hamad
  Abdul-Wahab R. Hamad , Waleed M. Al-Momani , Sana Janakat and Sawsan A. Oran
  Ellagic Acid (EA) is a complex planar molecule which demonstrates a variety of anticarcinogenic activities. Ellagic Acid acts as a scavenger to "bind" cancer-causing chemicals, making them inactive. It also has anti-bacterial, anti-viral properties. The concentration of EA was assessed in serum of twenty healthy volunteers over time interval from 0.15, 0.3, 1, 1.30, 2, 3, 6, 8 and 12 h. The serum concentration-time profile is presented after administration of 40 mg of ellagic acid to 20 healthy volunteers. Isocratic reversed phase liquid chromatographic method was developed for determination of low quantity of Ellagic Acid (EA) on reversed phase Lichrospher 100 RP-18, 5 μm (250 x 4.6 mm i.d) column and using methanol as mobile phase. The eluted EA was detected by UV set at 254 nm. Calibration curve for standard EA is linear with correlation coefficient of 0.9997 for detector response plotted against concentration range from 20-1000 ng/ml. The concentration of ellagic acid (Cmax) was highest in blood one hour (T max) after oral administration. It was 200.15±26.66 ng/ml., the mean serum elimination half-life was about 8.4±1.4 h. More than 50% of ellagic acid boud to plasma protein following oral administration, absorption of ionized ellagic acid occurs in stomach and intestine. Therefore, one capsule three times has drug bioavailability through all day.
  Abdul-Wahab R. Hamad and Hamad H. Al-Jamaien
  The bioavailability of the trace elements selenium, manganese, zinc, iron etc. has been investigated using human and experimental animals as the test observations. Twenty volunteers were used for this study. All volunteers have a deficient in calcium and magnesium. All patients were administered orally a tablet of combined calcium carbonate 292.5 mg and magnesium carbonate 232.3 mg produced by Commercial Company, Jordan. The mean concentration of blood calcium and magnesium after one week of tablet supplement was 100.8±8.3 and 15.7±1.0, respectively. The results showed that calcium-magnesium tablet is the most important elements to recover patient’s deficiency. It is thus concluded that combined calcium-magnesium carbonate are the best form for those elements for people deficiency.
  Rania M. Al-Groom , Abdul-Wahab R. Hamad and Saied M. Al-Daline
  The human body requires certain minerals for the overall health and proper functioning of the organ systems. The essential trace elements were very important for human life, which their imbalance in blood leads to very dangerous diseases (Zn, Cu, Fe, Cr, Se, Co, Mn and Mg). The purpose of this study was to evaluate the concentrations of Zinc, Copper, Iron, Magnesium, Chromium, Selenium, Cobalt and Manganese in serum of healthy adult females and males in Jordan. Serum levels of Zn, Cu, Fe, Mg, Cr, Se, Co, Mn and Mg were determined by flame and flameless atomic absorption spectrophotometer. Blood have been collected from1000 men and 1000 women apparently healthy Jordanian people aged 20-70 years. The mean concentration of zinc was between (0.96-1.02 and 0.8-1.02 μg/mL) in men and women, respectively. The concentration of zinc was slightly increased with ages. The mean values of copper were between (1.38-1.72 μg/mL), there is no significance deficiency in all ages and sexes. The average mean values of Fe were found to be (1.28-1.62 μg/mL) for men and (1.12-1.57 μg/mL) for women, with a deficiency of 5.9% in men and 8.5% in women. The chromium mean in men were between (0.04-0.055 μg/mL) with a deficiency of 43.06%, while in women were between (0.041-0.049 μg/mL), with a deficiency of 40.28%. The concentration of magnesium in blood serum was between 14.2-16.1 μg/mL for men and 14.3-16.3 μg/mL for women. The mean selenium concentrations in all healthy volunteers were in the range of 85-100 ng/mL for men and 82-99 ng/ml for women. The lowest levels of Se were shown in old people. The adult serum Co values were 0-34 ng/mL for men and 0-35 ng/mL for women. The cobalt deficiency was about 17% in men and women. The level of serum Manganese was 14-19 ng/mL for men and 11-15 ng/mL for women, it was noted that the level of Mn in men was higher than in women for all ages. The Mg concentrations of serum were 14.10±3.3 and 14.89±3.3 μg/mL for men and women. On the basis of this study finding and those of other reports, trace elements deficiency may contribute to diets and diseases through its significant effects on various organs parameters. It seems that the estimation of serum or plasma trace elements may help in investigation and treatment of some diseases in both males and females.
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