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Articles by A.T. Elsa
Total Records ( 4 ) for A.T. Elsa
  E.U. Etuk , A.M. Umarudeen , P.A. Onyeyili and A.T. Elsa
  A comparative plasma kinetics of sulphadimidine (100 mg kg-1, intravenous) studied by chemical assay in non-starved and starved rabbits has shown that; the mean peak plasma concentrations of the drug (101.70±5.74 μg mL-1) was higher in the starved than the non-starved animals (72.45±6.22 μg mL-1). The volume of distribution of the drug (Vdβ) and the total body clearance (CL) were significantly reduced after deprivation of food for 48 h in the animals. Equally, the elimination rate constant (β = 0.078 h-1) was higher in the non-starved than in the starved rabbits (β = 0.052 h-1). The study therefore concludes that, short term starvation has significantly increased the plasma concentrations and altered the kinetic profile of sulphadimidine following intravenous administration in rabbits. Thus, this factor should be considered when administering the drug to avoid dose dependent toxicity.
  E.U. Etuk , R.A. Adebiyi , A.T. Elsa and B.M. Agaie
  The acute and subchronic (repeat dose) oral toxicity of aqueous root extract of Securidaca longepedunculata was evaluated in mice. In the acute toxicity test, oral administration of limit dose of 5 g kg-1 of the extract produced neither mortality nor any acute signs of toxicity throughout the 14 days period of observation. In the subchronic toxicity study, there was no mortality recorded among the animals when varying doses of the extract (300, 900 and 2700 mg kg-1 body weight) were administered orally for 28 days consecutively. The weekly body and organ weights of the mice showed no significant differences between the control and the mice treated with the extract except on the last week (day 28) where there was significant increase (p<0.05) in the body weight of mice treated with 2,700 mg kg-1 of the extract. In the haematological analysis, there were significant (p<0.05) decrease in the Red Blood Cell (RBC) count at 2700 mg kg-1 and in Packed Cell Volume (PCV) of mice treated with 300 and 2,700 mg kg-1 of the extract, while the differential leucocytes count showed no differences in any of the parameter examined. Also, there was no significant changes in the biochemical parameters tested. There was neither any gross lesion nor histopathological changes observed in the organs (liver, kidney and brain) examined. These findings suggest that the aqueous root extract of S. longepedunculata could be relatively safe when administered orally in mice.
  E.U. Etuk , A.M. Umarudeen , P.A. Onyeyili and A.T. Elsa
  The tissue concentrations and kinetics of sulphadimidine (100 mg kg-1; intravenous) has been studied in normal and starved rabbits by chemical assay method. The results indicate that, different concentrations of the drug were obtained in the various tissues (liver, heart, kidney brain and skeletal muscle) examined. The drug persisted in the brain and skeletal muscle of the animals up to 12 days after its administration. The starved rabbits maintained consistently higher concentrations of the drug in its tissues as compared to the fed ones. The half-life of the drug was shortest in the liver (5.63 and 6.11 h) of the non-starved and starved rabbits, respectively. The elimination rate constants were correspondingly higher in the liver (0.210 and 0.230 h), respectively for the non-starved and starved rabbits. The study therefore concludes that, acute starvation can raise the tissue concentrations of sulphadimidine in rabbits and the safe withdrawal time following the administration of the drug should be in excess of twelve days.
  A.T. Elsa and P.A. Onyeyili
  Small intestinal atresia, an inheritable disease has a low incidence of occurrence in animals. In veterinary practice atresia is a commonly encountered congenital problems of the gastrointestinal system of small ruminants. This study therefore reports two clinical cases of small intestinal atresia and its management in Sokoto red goats.
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