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Articles by A.R. Kothai
Total Records ( 2 ) for A.R. Kothai
  S. Kameshwaran , C. Jothimanivannan , R. Senthilkumar and A.R. Kothai
  Objective: Tecoma stans (Bignoniaceae) is conventionally used for a variety of treatments and also in the cases of arteriosclerosis and circulatory irregularities. Hence, the present exploration was intended to assess the potential effect of Methanol Extract of flowers of Tecoma stans (METS) on obesity and hyperlipidiemia on Atherogenic diet induced obese rats. Methods: METS at the doses of 100 and 200 mg kg-1 were administered along with atherogenic diet for a period of 42 days. Parameters such as body weight, body temperature, serum lipid profiles, SGOT and SGPT were evaluated. Results: METS at the dose of 200 mg kg-1 significantly (p<0.001) corrected the altered parameters, similar to that of standard drug sibutramine (2 mg kg-1). Conclusion: From the observations of the study performed, it could be predicted that Tecoma stans flower extract exerted significant anti-obese and anti- hyperlipidemic effects in rats fed on Atherogenic diet.
  S. Kameshwaran , A.R. Kothai , C. Jothimanivannan and R. Senthilkumar
  Objective: Tecoma stans is a plant with a diversity of ethnic medicinal uses along with antioxidant activity. Hence, we have intended to screen hepatoprotective activity with ethanolic (EETS) extract of flowers of Tecoma stans. Methods: Powder of flower petals extracted with ethanol and it was subjected for phytochemical screening to categorize the different phytoconstituents. Hepatoprotective activity of the extract was studied against the liver injury induced by paracetamol, carbon tetrachloride, thioacetamide and chronic liver damage induced by carbon tetrachloride in rats. Results: The extract significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. EETS at the dose of 500 mg kg-1, p.o. prevented the increase in liver weight when compared to hepatoxin treated control while the extract at the dose 250 mg kg-1 was ineffective except in the paracetamol induced liver damage. In the chronic liver injury induced by carbon tetrachloride, EEPG at the dose of 500 mg kg-1, p.o. was found to be more effective than the extract at the dose of 250 mg kg-1, p.o.. Histological examination of the liver tissues supported the hepatoprotection. Conclusion: It is concluded that both extracts of flowers of Tecoma stans possesses good hepatoprotective activity.
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