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Articles by A.M. Oloyede
Total Records ( 4 ) for A.M. Oloyede
  A.M. Oloyede , J. Okpuzor , O. Omidiji and H.O.C. Mbagwu
  An herbal cocktail comprising of seeds, stem and leaves of seven African plants extensively used in South-Western Nigeria for the management and treatment of inflammation and tumor of the breast was investigated for analgesic and anti-inflammation activities. The analgesic properties of the ethanol extract was investigated using three in vivo mice test models (mice constriction, hot-plate and formalin-induced pain test) while anti-inflammatory activities of the same were evaluated using the Carageenan and egg albumin-induced oedema test systems in vivo. Present findings indicated that the cocktail at a concentration of 400-1600 mg kg- produced significant inhibition (p<0.05) response in both phases of the formalin pain model. The acetic acid-induced abdominal constriction also showed a dose dependent pain inhibition pattern directly related to the amount of extract administered. Instructively, the extract exhibited higher analgesic activity than acetylsalicylic acid but lower than morphine (2 mg kg-). The cocktail (400-1600 mg kg-) exhibited anti-inflammatory activity but inhibition observed at 1600 mg kg- in the 5 and 6 h was very significant. It compared favourably with the reference drug (Indomethacin 10 mg kg-). Consequently, it is our suggestion that the cocktail may possess analgesic and anti-inflammatory properties.
  A.M. Oloyede , J. Okpuzor and O.O. Aina
  To investigated the polyherbal formula (Joloo) for its antimalarial and anti-pyretic properties on mice and rats. In the antimalarial study mice were infected with Plasmodium berghei using three doses (1600, 800 and 400 mg kg-1 b.wt.). Pyrexia was induced in the rats by the administration of 10 mg kg-1 b.wt., of 2,4-Dinitrophenol intraperitoneally while measurement was by inserting a clinical thermometer into their anal cavities for about 2 min. Chloroquine and acetylsalicylic acid were used as reference drugs in mice and rats respectively, while water served as control for both. The antiplasmodial study involved two phases; the suppressive where mice were administered plant extract per os for four days immediately after inoculation and blood smear prepared on the fifth day and the curative phases where mice were inoculated with parasites three days before administration of extract so as to allow for full development of parasites. They were administered the extract orally for five consecutive days and blood smears prepared during the period of administration and five days post administration. During the 5-days suppressive study, the herbal formulation (Joloo) showed significant daily dose-dependent decrease in parasitaemia and compared favourably with the reference drug (Chloroquine). It was observed however that the 1600 and 800 mg achieved a total 100% chemosuppression of parasitaemia, while 400 mg kg-1 b.wt. dose was 44.5%. During the curative study, there was significant dose-dependent decrease in parasitaemia during the 5-days period of administration and subsequent increase in parasitaemia in the remaining 5-days post administration. In both suppressive and curative assays, chloroquine achieved 100% chemosuppression while Joloo achieved 100% chemosuppression in the suppressive assay. Besides, Joloo inhibited parasitaemia only during administration in the curative study after which a progressive increase in parasitaemia was observed during post-administration. In the anti-pyretic study, Joloo significantly reduced hyperthermia in rats dose-dependently. This clearly suggests that Joloo contain biologically active substances with the potential of managing and treating malaria and fever. It provides scientific evidence to support the isolation and development of biologically active components as anti-malarial and antipyretic agents.
  A.M. Oloyede , J. Okpuzor and O.O. Omidiji
  Joloo is a traditional herbal formulation used in the management of tumour of the breast in southwestern Nigeria. The acute and subchronic toxicity studies of Joloo have been reported previously but the chronic toxicity has not been investigated. The study was undertaken to evaluate the long-term toxic effect of Joloo on mice. Ethanolic extract of Joloo was administered to four groups of mice weighing 27.5±1.4 (N = 10/group) Repeated doses (400, 800 and 1600 mg kg-1 b.wt.) were administered orally for 91 days. Parameters observed include, body and relative organ weights, haematology, biochemical analysis, antioxidant activities and histologic studies. There were no adverse effects on the general condition, body and relative organ weight, red blood cells and white blood cell. However there were significant increase in leucocytes, GPx, CAT and SOD at 800 and 1600 mg kg-1 b.wt. The histoarchitecture of the liver, heart and the spleen revealed slight alteration (mild necrosis) and there was dose-dependent though insignificant increase in some of the biochemical analytes (ALT and AST) at 1600 mg kg-1 b.wt. Based on these findings it can be inferred that Joloo is devoid of toxicity at 400 and 800 mg kg-1 b.wt. and possess strong antioxidant activities, whereas high dose (1600 mg kg-1 b.wt.) may be associated with some toxicity concerns.
  A.M. Oloyede , O. Ogunlaja and A. Ogunlaja
  ‘Adire and Kampala’ (Tie and dye) have been produced in Itoku, Abeokuta, Ogun state-Nigeria for over a century. Large quantity of water has been involved and effluents have been discharged into surrounding sources of water without adequate treatment. The evaluation of the sub-chronic toxicity of the Adire and Kampala textile effluents is done by investigating its effect on the weights, histopathologic and haematologic indices in normal albino mice. Normal albino mice of either sex weighing between 23 and 37 g were divided into five groups of 10 animals each. Four concentrations were orally administered 1, 5, 25 and 50% while control animals received distilled water over 28 days. Animals were weighed weekly and sacrificed after day 28. Organs were harvested, weighed and subjected to histopathologic assessment. Blood samples were used for haematological studies. The 30 and 50% mortality was observed in the groups administered 25 and 50% concentration, respectively and several signs of toxicity were observed in other groups. Decreased organs and body weight, WBC, PCV and Hb significantly different from control were observed. Histopathologic studies showed remarkable distortion in the histo-architecture of the visceral organs, like alveoli disruption, spleen pigmentation, tubular necrosis in kidney and hemorrhage in the heart. The mortality observed, decreased haematologic indices, internal organs, body weight and gross distortion in the histo-architecture of the visceral organs are indications that the ‘Adire and Kampala’ textile effluents contain substances that are toxic to the animal physiology. These substances which may have seeped into surrounding rivers and wells in Abeokuta town can cause severe health malaise in the inhabitants of such area.
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