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by
A.K.M. Motahar Hossain |
Total Records (
4 ) for
A.K.M. Motahar Hossain |
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Md. Belal Hossain
,
Mamunur Rashid
and
A.K.M. Motahar Hossain
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The aim of the present study was to investigate the release of ibuprofen (IB) from matrix tablets using a combination of water insoluble waxy materials with hydrophilic polymers. The waxy materials were added as additives to the hydrophilic polymer, hydroxy propyl methyl cellulose (HPMC). Bees wax (BW), cetyl alcohol (CA) and stearic acid (SA) used as waxy materials that were added in increasing amount (up to 30% of total weight of tablet) to the HPMC based sustained release (SR) matrix tablets. The results showed that the matrix tablets using all the additives released the drug by zero order mechanism. Addition of waxy materials into the matrix significantly decreased the rate of drug release due to the reduction in penetration of the dissolution fluid. From the release profiles excellent correlation was found between the concentration of waxy materials and ibuprofen release rate. |
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Md. Belal Hossain
,
Mamunur Rashid
and
A.K.M. Motahar Hossain
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The effects of various percentages (0, 3, 6, 9, 12 and 15%) of Glycerol Mono Stearate (GMS), Stearic Acid (SA) and Cetyl Alcohol (CA) on the release rate of Ibuprofen (IB) from polyethylene glycol-4000 (PEG)-based suppositories were studied. Ibuprofen suppositories of PEG-4000 base were prepared using GMS, SA and CA separately in different formulations by fusion method. Dissolution studies showed a rapid release of the drug during 30-60 min from the PEG-based suppositories of IB and almost 75% of the drug was released within this period. But the incorporation of waxy additives GMS, CA and SA in the formulation reduces this rapid release rate of the drug. Three percent GMS containing PEG-based suppositories liberated about 70.0% of the drug within 6 h whereas maximum 45.0% and 51.0% of drug were liberated from 3% SA and 3% CA containing PEG-based suppositories, respectively, within the same time. The drug release reducing capabilities of the waxy additives were found to be in the following order SA>CA>GMS. Utilizing this capability of the additives, sustained release suppositories of ibuprofen could be formulated. |
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K.A. Salam
,
A.K.M. Motahar Hossain
,
A.H.M. Khurshid Alam
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F. Pervin
and
N. Absar
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The physico-chemical characteristics °of oils extracted from six different parts of hilsa °fish (Hilsa ilisha) like dorsal, ventral, tail, egg, liver and brain were analyzed. The physical characteristics such as the specific gravity, refractive index, smoke point, flash point, fire point, cloud point, solidification point and pour point of the hilsa fish oils from the different parts presently examined were ranged from 0.920 to 0.932, 1.4700 to 1.4722 at 25°C, 220 to 228°C, 322 to 330°C, 350 to 364°C, 2 to 2.4°C, -10 to -5°C and -7 to 6°C, respectively. The chemical properties such as saponification value, iodine value, peroxide value, acid value, % FFAs and unsaponifiable matters of the hilsa fish oils from different parts were found to be varied from 180.28 to 194.00, 80.70 to 126.40, 7 to 10, 4.16 to 12.00, 2.08 to 6.00 and 1.58 to 7.00%, respectively. The saturated and unsaturated fatty acids present in the oil samples were mainly myristic acid (5.44 to 7.24%), palmitic acid (22.00 to 27.08%), stearic acid (4.00 to 6.32%), palmitolenic acid (12 to 14%), oleic acid (26.08 to 29.78%), linoleic acid (0.92 to 2.20%) and linolenic acid (0.82 to 1.08%). The storage effect on the hilsa fish oils, which were obtained from different parts for the production of fatty acids by the action of lipase have been studied after storing the samples at low temperature (-10 to 0°C) and at room temperature (25 to 28°C). The contents of % FFA were initially low but increased rapidly on storage. It has been shown that lipase enzyme in hilsa fish oil is active even at temperature -10°C. The hydrolytic deterioration of hilsa fish oils were found to be more effective at 0°C than that from -10°C. Further, the qualities of hilsa fish oils were deteriorated slightly further when stored at 25°C. |
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Sharif Mohammad Shaheen
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Abdul Khalek Molla
,
Maruf Ahmed
and
A.K.M. Motahar Hossain
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Applications of various percentages (0, 2, 4, 8, 12 and 16%) of Glycerol Mono Stearate (GMS), Stearic Acid (SA) and
Cetyl Alcohol (CA) on the release rate of Naproxen (NP) from Polyethylene Glycol 4000 (PEG)-based suppositories were
studied in order to reduce rectal mucosal damage and also to investigate their release pattern. Naproxen suppositories of
PEG-4000 base were prepared using GMS, SA and CA separately in different formulations by fusion method. Dissolution studies
showed a rapid release of the drug during 30-60 min from the PEG-based suppositories of NP and almost 65% of the drug was
released within this period. But the incorporation of waxy additives GMS, CA and SA in the formulation reduces this rapid
release rate of the drug. Two percent GMS containing PEG-based suppositories liberated about 69.0% of the drug within 6 h
whereas maximum 45.0 and 32.0% of drug were liberated from % SA and % CA containing PEG-based suppositories, respectively,
within the same time. The drug release reducing capabilities of the waxy additives were found to be in the following order
CA>SA>GMS. Utilizing this capability of the additives, sustained release suppositories of Naproxen could be formulated. |
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