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Articles by A.K. Sharma
Total Records ( 3 ) for A.K. Sharma
  C.C. Satheesh , A.K. Sharma , P. Dwivedi , K. Prasanna , R.D. Patil and S. Rahul
  Ochratoxins are potent mycotoxins elaborated by Aspergillus and Penicillium species. Incidence of ochratoxin A (OT-A) in feed and natural occurrence of ochratoxicosis in animals have been reported from various parts of the world, including India. In this study, we report the immunosuppressive effect of ochratoxin A in rats. The cell mediated immune responses, as assessed by 2, 4-di-nitro-chloro-benzene (DNCB) induced contact hypersensitivity reaction and macrophage function test ( NO2- production assay) were found to be decreased significantly in OT-A intoxicated rats as compared with those in controls. Humoral immune response, assessed by antibody titres against sheep red blood cells, was also found to be decreased in toxin fed rats. The haemato-biochemical alterations such as leucopenia, lymphopenia and hypoproteinemia associated with OT-A toxicity were also indicative of immunosuppression. These findings suggest that OT-A induces the suppression of both humoral and cell mediated immune responses and must be taken into account while dealing with cases of vaccination failure or frequent bacterial and viral infections in livestock and poultry.
  P. Chattopadhyay , A. Garg , V.P. Varshey , A.K. Sharma and S.S. Agrawal
  The hydroalcoholic extract of whole plant of Phyllanthus amarus Linn showed significant increase in activity of insulin at 200 mg kg-1 dose in regenerative hepatocytes against alcohol induced liver cell injury in partially hepatectomised albino rats. The blood sample were collected from the abdominal aorta and the serum insulin estimated by radio immuno assay and regenerative capacity measured by thymidine kinase assay by 3H thymidine incorporation into hepatic DNA which showed that Phyllanthus amarus Linn has a potential role in insulin action during liver cell regeneration.
  B.R. Sharma , A.K. Sharma , Swati Sharma and Harshabad Singh
  Road-traffic injuries are recognized as a major public health problem all over the world accounting for maximum morbidity and mortality following trauma. The objective of this study was to analyze the trends of fatal road traffic crashes and to find measures for the prevention of their causative factors. We examined the pattern of fatal injuries among road traffic crash victims in 1109 cases subjected to medicolegal autopsy during 1996 to 2005 at the department of forensic medicine, in Government Medical College and Hospital Chandigarh. Young adults of the age-group 16 to 30 years constituted the majority of the victims, 608 (55%), while the number decreased with the advancing age. The overall male: female ratio was 5:1. Pedestrians 429 (39%) and motorized two wheeler users 378 (34%) constituted the majority. Motorized heavy vehicles were responsible for 386 (35%) deaths. Head injury in 676 (61%), followed by hemorrhagic shock in 266 (24%) were the main causes of death. 729 (66%) victims died within 24 hours while 307 (28%) had a survival of 2 to 7 days.
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