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| Articles
by
A.E. Oji |
Total Records (
2 ) for
A.E. Oji |
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I.R. Iroha
,
A.E. Oji
,
O.K. Nwosu
and
E.S. Amadi
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The antimicrobial activities of Savlon®,
Izal® and Z-Germicide® disinfectants against
23 clinical isolates of Pseudomonas aeruginosa were evaluated.
The agar well diffusion technique and broth dilution technique for determining
Minimum Inhibitory Concentration (MIC μg mL-1) were employed.
The overall result of the study showed that Savlon® and
Izal® have appreciable antimicrobial activity against the
P. aeruginosa isolates, while Z-Germicide® produced
low activity. The use of Savlon® and Izal®
disinfectants in hospitals and clinics in Nigeria, is hereby suggested. |
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I.R. Iroha
,
E.S Amadi
,
J.O. Orji
,
A.C. Ogabus
,
A.E. Oji
and
C.O. Esimone
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The present study evaluated the antimicrobial effect
of different combinations of gentamicin and floroquinolones (ciprofloxacin,
ofloxacin, perfloxacin and gatifloxacin) against extended spectrum beta
lactamase (ESBL) positive E. coli isolates using checkerboard method.
One hundred and four clinical isolates of E. coli obtained from
urine (26), blood (24), stool (20), sputum (19) and semen (14) were investigated
for ESBL production. Fifteen (14.4%) were positive for ESBL production
in the following order: 4(3.8%) from urine, 3(2.8%) from blood, 3(2.8%)
from stool, 3(2.8%) from sputum and 2(1.9%) from semen. Five representative
ESBL positive isolates, one from each specimen, were investigated for
their susceptibility patterns to different gentamicin and floroquinolone
combinations. The combinations of gentamicin and ciprofloxacin, perfloxacin
and gatifloxacin, respectively at different ratios were predominantly
synergistic in activity while gentamicin and ofloxacin combinations were
primarily indifference in activity. These results may have some therapeutic
significance in the management of ESBL infections especially in areas
of the world where ESBL organisms are either emerging or re-emerging. |
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